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131.  Increasing temperature and productivity change biomass, trophic pyramids and community-level omega-3 fatty acid content in subarctic lake food webs.LinkIT
Keva O, Taipale SJ, Hayden B, Thomas SM, Vesterinen J, Kankaala P, Kahilainen KK
Global change biology Glob Chang Biol Increasing temperature and productivity change biomass, trophic pyramids and community-level omega-3 fatty acid content in subarctic lake food webs. 10.1111/gcb.15387 Climate change in the Arctic is outpacing the global average and land-use is intensifying due to exploitation of previously inaccessible or unprofitable natural resources. A comprehensive understanding of how the joint effects of changing climate and productivity modify lake food web structure, biomass, trophic pyramid shape and abundance of physiologically essential biomolecules (omega-3 fatty acids) in the biotic community is lacking. We conducted a space-for-time study in 20 subarctic lakes spanning a climatic (+3.2°C and precipitation: +30%) and chemical (dissolved organic carbon: +10 mg/L, total phosphorus: +45 µg/L and total nitrogen: +1,000 µg/L) gradient to test how temperature and productivity jointly affect the structure, biomass and community fatty acid content (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) of whole food webs. Increasing temperature and productivity shifted lake communities towards dominance of warmer, murky-water-adapted taxa, with a general increase in the biomass of primary producers, and secondary and tertiary consumers, while primary invertebrate consumers did not show equally clear trends. This process altered various trophic pyramid structures towards an hour glass shape in the warmest and most productive lakes. Increasing temperature and productivity had negative fatty acid content trends (mg EPA + DHA/g dry weight) in primary producers and primary consumers, but not in secondary nor tertiary fish consumers. The massive biomass increment of fish led to increasing areal fatty acid content (kg EPA + DHA/ha) towards increasingly warmer, more productive lakes, but there were no significant trends in other trophic levels. Increasing temperature and productivity are shifting subarctic lake communities towards systems characterized by increasing dominance of cyanobacteria and cyprinid fish, although decreasing quality in terms of EPA + DHA content was observed only in phytoplankton, zooplankton and profundal benthos. © 2020 John Wiley & Sons Ltd. Keva Ossi O https://orcid.org/0000-0002-5381-3879 Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland. Taipale Sami J SJ https://orcid.org/0000-0001-7510-7337 Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland. Hayden Brian B https://orcid.org/0000-0002-8524-7373 Biology Department, Canadian Rivers Institute, University of New Brunswick, Fredericton, NB, Canada. Thomas Stephen M SM https://orcid.org/0000-0001-5125-691X Department of Environmental Systems Science, Crowther Lab, Institute of Integrative Biology, ETH-Zürich, Zürich, Switzerland. Department of Fish Ecology and Evolution, Center of Ecology, Evolution and Biogeochemistry, EAWAG Swiss Federal Institute of Aquatic Science and Technology, Kastanienbaum, Switzerland. Vesterinen Jussi J https://orcid.org/0000-0003-3126-2698 Department of Environmental and Biological Sciences, University of Eastern Finland, Joensuu, Finland. Kankaala Paula P https://orcid.org/0000-0002-1422-2806 Department of Environmental and Biological Sciences, University of Eastern Finland, Joensuu, Finland. Kahilainen Kimmo K KK https://orcid.org/0000-0002-1539-014X Lammi Biological Station, University of Helsinki, Lammi, Finland. Kilpisjärvi Biological Station, University of Helsinki, Kilpisjärvi, Finland. eng Ministry of Agriculture and Forestry of Finland Emil Aaltonen Foundation 1140903 Academy of Finland 1268566 Academy of Finland 310450 Academy of Finland A30205 European Regional Development Fund University of Jyväskylä Journal Article 2020 10 30 England Glob Chang Biol 9888746 1354-1013 IM DOC food web structure forestry land-use nutrients omega-3 HUFA trophic level trophic pyramid 2020 05 15 2020 08 31 2020 09 27 2020 10 30 6 2 2020 10 31 6 0 2020 10 31 6 0 aheadofprint 33124178 10.1111/gcb.15387 REFERENCES, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>132.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>A physiology-based Earth observation model indicate stagnation in the global gross primary production during recent decades.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Tagesson T, Tian F, Schurgers G, Horion S, Scholes R, Ahlström A, Ardö J, Moreno A, Madani N, Olin S, Fensholt R<br><font color=gray><i>Global change biology, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>133.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Characterization of dermal sensitization potential for industrial or agricultural chemicals with EpiSensA.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Mizumachi H, LeBaron MJ, Settivari RS, Miyazawa M, Marty MS, Sakaguchi H<br><font color=gray><i>Journal of applied toxicology : JAT J Appl Toxicol Characterization of dermal sensitization potential for industrial or agricultural chemicals with EpiSensA. 10.1002/jat.4076 The regulatory community is transitioning to the use of nonanimal methods for dermal sensitization assessments; however, some in vitro assays have limitations in their domain of applicability depending on the properties of chemicals being tested. This study explored the utility of epidermal sensitization assay (EpiSensA) to evaluate the sensitization potential of complex and/or "difficult to test" chemicals. Assay performance was evaluated by testing a set of 20 test chemicals including 10 methacrylate esters, 5 silicone-based compounds, 3 crop protection formulations, and 2 surfactant mixtures; each had prior in vivo data plus some in silico and in vitro data. Using the weight of evidence (WoE) assessments by REACH Lead Registrants, 14 of these chemicals were sensitizers and, six were nonsensitizers based on in vivo studies (local lymph node assay [LLNA] and/or guinea pig studies). The EpiSensA correctly predicted 16/20 materials with three test materials as false positive and one silane as false negative. This silane, classified as weak sensitizer via LLNA, also gave a "false negative" result in the KeratinoSens? assay. Overall, consistent with prior evaluations, the EpiSensA demonstrated an accuracy level of 80% relative to available in vivo WoE assessments. In addition, potency classification based on the concentration showing positive marker gene expression of EpiSensA was performed. The EpiSensA correctly predicted the potency for all seven sensitizing methacrylates classified as weak potency via LLNA (EC3 ? 10%). In summary, EpiSensA could identify dermal sensitization potential of these test substances and mixtures, and continues to show promise as an in vitro alternative method for dermal sensitization. © 2020 John Wiley & Sons, Ltd. Mizumachi Hideyuki H https://orcid.org/0000-0001-8778-1951 R&D, Safety Science Research, Kao Corporation, Tochigi, Japan. LeBaron Matthew J MJ Toxicology & Environmental Research & Consulting, Dow Chemical Company, Midland, Michigan, USA. Settivari Raja S RS Corteva Agriscience, Haskell R&D Center, Newark, Delaware, USA. Miyazawa Masaaki M R&D, Safety Science Research, Kao Corporation, Tochigi, Japan. Marty Mary Sue MS Toxicology & Environmental Research & Consulting, Dow Chemical Company, Midland, Michigan, USA. Sakaguchi Hitoshi H R&D, Safety Science Research, Kao Corporation, Tochigi, Japan. eng Journal Article 2020 10 30 England J Appl Toxicol 8109495 0260-437X IM DPRA EpiSensA KeratinoSens? h-CLAT in vitro skin sensitization 2020 04 22 2020 09 02 2020 09 02 2020 10 30 6 0 2020 10 31 6 0 2020 10 31 6 0 aheadofprint 33124094 10.1002/jat.4076 REFERENCES, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>134.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Impaired Recovery is Associated with Increased Injury and Illness: A Retrospective Study of 536 Female Netball Athletes.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Horgan BG, Drew MK, Halson SL, Piromalli LE, Drinkwater EJ, Chapman DW, Haff GG<br><font color=gray><i>Scandinavian journal of medicine & science in sports, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>135.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Salvia officinalis mitigates uterus and liver damages induced by an estrogen deficiency in ovariectomized rats.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Koubaa-Ghorbel F, Chaâbane M, Jdidi H, Turki M, Makni-Ayadi F, El Feki A<br><font color=gray><i>Journal of food biochemistry J Food Biochem Salvia officinalis mitigates uterus and liver damages induced by an estrogen deficiency in ovariectomized rats. e13542 10.1111/jfbc.13542 The present study evaluated the antioxidant activity of Salvia officinalis (sage) and its protective effect on estrogen deficiency in ovariectomized rats. Female Wistar rats were treated during either 15 or 30 days as follows: group C: negative controls, group S: positive controls treated with sage leaves, ovariectomized rats (group OVX) and ovariectomized rats receiving either sage (OVX-S) or hormonal (Group OVX-E) treatments, respectively. After 15 and 30 days of treatments, OVX rats showed a gain in body weight and an increase of absolute and relative liver weights. Meanwhile, absolute and relative uterus weights were decreased. Moreover, ovariectomy altered plasma transaminases' activities, lipid profile, and disrupted the redox status of liver and uterine tissues. It affected also the reproductive tract by decreasing the uterus glycogen content and plasma LDH activity. Supplementation of sage via the diet reduced weight gain and oxidative stress resulting from estrogen deficiency. PRACTICAL APPLICATIONS: During menopause, sexual hormone deficiency, especially estrogen, causes several morphological and physiological disturbances in liver and uterus tissues. In fact, the body weight gain and disturbances of redox status in liver and uterus were the main health problems detected after menopause. Sage leaves, used as medicinal plant, exerted its beneficial effects in the management of menopause disorders. As an important source of antioxidants, sage leaves could prevent obesity and oxidative damage in the liver and uterus resulting from estrogen deficiency. © 2020 Wiley Periodicals LLC. Koubaa-Ghorbel Fatma F https://orcid.org/0000-0001-7412-4805 Sciences Faculty of Sfax, Sfax University, Sfax, Tunisia. Chaâbane Mariem M National Engineering School of Sfax, Sfax University, Sfax, Tunisia. Jdidi Hajer H Sciences Faculty of Sfax, Sfax University, Sfax, Tunisia. Turki Mouna M CHU H. Bourguiba, Sfax University, Sfax, Tunisia. Makni-Ayadi Fatma F CHU H. Bourguiba, Sfax University, Sfax, Tunisia. El Feki Abdelfattah A Sciences Faculty of Sfax, Sfax University, Sfax, Tunisia. eng Journal Article 2020 10 29 United States J Food Biochem 7706045 0145-8884 IM estrogen deficiency lipid profile liver rats redox status sage uterus 2020 07 22 2020 09 10 2020 10 07 2020 10 30 5 59 2020 10 31 6 0 2020 10 31 6 0 aheadofprint 33124046 10.1111/jfbc.13542 REFERENCES, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>136.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Diagnostic accuracy of anti-phospholipase A2 receptor (PLA2R) antibodies in idiopathic membranous nephropathy: an Italian experience.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Porcelli B, Guarnieri A, Ferretti F, Garosi G, Terzuoli L, Cinci F, Tabucchi A, Tampoia M, Abbracciavento L, Villani C, Deleonardi G, Grondona AG, Mazzolini M, La Manna G, Santostefano M, Infantino M, Manfredi M, Spatoliatore G, Rosati A, Somma C, Bizzaro N<br><font color=gray><i>Journal of nephrology, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>137.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>An Ecologic Study of Disparities in COVID-19 Incidence and Case Fatality in Oakland County, MI, USA, During a State-Mandated Shutdown.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Akanbi MO, Rivera AS, Akanbi FO, Shoyinka A<br><font color=gray><i>Journal of racial and ethnic health disparities, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>138.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>How Giving Birth Makes Sense: A Questionnaire Study on Existential Meaning-Making Among Mothers Giving Birth Preterm or at Term.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Hansen LB, Hvidt NC, Mortensen KE, Wu C, Prinds C<br><font color=gray><i>Journal of religion and health, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>139.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Fosfomycin Dosing Regimens based on Monte Carlo Simulation for Treated Carbapenem-Resistant <i>Enterobacteriaceae</i> Infection.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Kanchanasurakit S, Santimaleeworagun W, McPherson CE, Piriyachananusorn N, Boonsong B, Katwilat P, Saokaew S<br><font color=gray><i>Infection & chemotherapy, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>140.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Phelligridin D maintains the function of periodontal ligament cells through autophagy in glucose-induced oxidative stress.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Kim JE, Kim TG, Lee YH, Yi HK<br><font color=gray><i>Journal of periodontal & implant science, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br><br><br><table cellspacing=0 cellpadding=0 align=center><tr valign=bottom><td align=center><a href=http://ubio.org/portal/index.php?search=negative&category=l&client=pubmed&startPage=13><img src=p.png border=0></a></td><td align=center><a 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