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51.  Screening of novel excipients for freeze-dried protein formulations.LinkIT
Holm TP, Meng-Lund H, Rantanen J, Jorgensen L, Grohganz H
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2021
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

52.  Increased DNA strand breaks and neoplastic transformation in human bladder cells treated with pioglitazone.LinkIT
Atl? ?ekero?lu Z, ?ekero?lu V, Konta? Yedier S, ?lkun E, Liou LS
Environmental and molecular mutagenesis Environ Mol Mutagen Increased DNA strand breaks and neoplastic transformation in human bladder cells treated with pioglitazone. 143-154 10.1002/em.22424 Pioglitazone (PIO), an oral hypoglycemic agent, is used in the treatment of type 2 diabetes. Some studies have suggested that an increased risk of bladder cancer with PIO exposure, while the others reported there is no such relationship. Therefore, it is doubtful whether PIO can increase the risk of bladder cancer. The effects of PIO on DNA damage and/or transformation of human bladder cells are not fully known. We investigated the effects of PIO on cytotoxicity, DNA single and double strand breaks and repair and neoplastic transformation in human bladder cells (hTU1) treated with 10, 20, and 40??M PIO for 24, 48 and 72?hr. PIO decreased cell viability in a concentration-dependent manner. Increased levels of comet parameters showed that PIO and its metabolites can significantly induce DNA double strand breaks at all concentrations tested. PIO also significantly induced the formation of phosphorylated H2AX and p53 binding protein 1 foci. DNA damage was not repaired in a 24?hr recovery period. PIO can also induce malignant transformation of human bladder cells exhibiting loss of contact inhibition and anchorage independent growth. This is the first study to indicate that PIO can induce DNA damage and malignant transformation, reduce or alter the DNA repair capacity in human bladder cells. From these results, we suggest that patients with diabetes treated with PIO may have an increased risk of bladder cancer. © 2021 Wiley Periodicals LLC. Atl? ?ekero?lu Zülal Z https://orcid.org/0000-0002-3552-3819 Department of Molecular Biology and Genetics, Faculty of Science and Letters, Ordu University, Ordu, Turkey. ?ekero?lu Vedat V Department of Molecular Biology and Genetics, Faculty of Science and Letters, Ordu University, Ordu, Turkey. Konta? Yedier Seval S Department of Molecular Biology and Genetics, Faculty of Science and Letters, Ordu University, Ordu, Turkey. ?lkun Emre E Department of Molecular Biology and Genetics, Faculty of Science and Letters, Ordu University, Ordu, Turkey. Liou Louis S LS Department of Urology, Cambridge Health Alliance, Cambridge, Massachusetts, USA. eng TF-1533 Scientific Research Funding of Ordu University (Turkey) 118Z542 Türkiye Bilimsel ve Teknolojik Ara?tirma Kurumu Journal Article United States Environ Mol Mutagen 8800109 0893-6692 IM DNA damage and repair DNA strand breaks bladder cells neoplastic transformation pioglitazone 2020 10 09 2021 01 19 2021 01 22 2021 1 27 6 0 2021 1 27 6 0 2021 1 26 12 13 ppublish 33496997 10.1002/em.22424 REFERENCES, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>53.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Contemporary Management of Urinary Tract Infection in Children.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Mattoo TK, Shaikh N, Nelson CP<br><font color=gray><i>Pediatrics, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>54.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Overcoming the Limits of Reconditioning: Seventeen Hours of Ex-Vivo Lung Perfusion (EVLP) with Successful Transplantation from Uncontrolled Circulatory Death Donor.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Palleschi A, Rosso L, Ruggeri GM, Croci GA, Rossetti V, Citerio G, Grasselli G, Nosotti M, Zanella A<br><font color=gray><i>Transplantation, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>55.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Androgen Misuse and Abuse.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Handelsman DJ<br><font color=gray><i>Endocrine reviews, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>56.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>The usefulness of measuring the anion gap in diagnosing metformin-associated lactic acidosis: a case series.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Ruiz-Ramos J, Lozano-Polo L, Juanes-Borrego A, Agra-Montava I, Puig-Campmany M, Mangues-Bafalluy MA<br><font color=gray><i>Journal of medical case reports, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>57.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Diagnosis of Neonatal Late-Onset Infection in Very Preterm Infant: Inter-Observer Agreement and International Classifications.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Bury G, Leroux S, Leon Borrego C, Gras Leguen C, Mitanchez D, Gascoin G, Thollot A, Roué JM, Carrault G, Pladys P, Beuchée A<br><font color=gray><i>International journal of environmental research and public health, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>58.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Fingertip pulse oximetry prevented premature declaration of death.</a><a 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Shashi Kumar BM, Gupta LK, Budamakuntla L, Kumrah L, Das S, Ovhal AG, Mandal NK, Mukherjee S, Anoop TV, Thakur BK, Eswari L, Samson JF, Patel KB, Rajagopalan R, Gupta S, Kaur T<br><font color=gray><i>Indian journal of dermatology, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>60.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>[How to reduce the antibacterial load in the treatment of acute tonsillitis and pharyngitis? Possible tactics and practical approaches].</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Meskina ER, Stashko TV<br><font color=gray><i>Vestnik otorinolaringologii, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br><br><br><table cellspacing=0 cellpadding=0 align=center><tr valign=bottom><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=5><img src=p.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=1><img src=o_yellow.png border=0></a></td><td align=center><a 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src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=9><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=10><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=11><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=12><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=13><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=14><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=15><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=7><img src=rtal.png border=0></a></td></tr><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=5>«</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=1>1</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=2>2</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=3>3</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=4>4</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=5>5</a></td><td align=center>6</td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=7>7</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=8>8</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=9>9</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=10>10</a></td><td align=center><a 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