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91.  Stratum corneum levels of inflammatory mediators and natural moisturizing factor in patch test reactions to thiurams and fragrances and their possible role in discrimination between irritant and allergic reactions to hapten mixtures.LinkIT
Brans R, Jakasa I, Goc S, John SM, Kezic S
Contact dermatitis Contact Dermatitis Stratum corneum levels of inflammatory mediators and natural moisturizing factor in patch test reactions to thiurams and fragrances and their possible role in discrimination between irritant and allergic reactions to hapten mixtures. 299-307 10.1111/cod.13746 Patch test (PT) reactions to thiuram mix (TM) and fragrance mix (FM) I or II without concomitant reactions to their single constituents are potentially caused by the irritant properties of the mixes. Comparing inflammatory profiles of PT reactions to TM, FM I, FM II, and their constituents and assessing their potential in discrimination of irritant and allergic reactions. Levels of 14 cytokines and natural moisturizing factor (NMF) were determined in stratum corneum samples collected from PT reactions to TM, FM I or II, their constituents, and petrolatum (pet.) control sites in 36 individuals. Levels of interleukin (IL)-16, chemokine (CXC motif) ligand (CXCL) 8, CXCL10, chemokine (CC motif) ligand (CCL) 17, and CCL22 were significantly increased in reactions (+, ++) to thiurams and fragrances compared to their petrolatum. controls, except for PT reactions to FM I/II with negative breakdown testing in which, however, decreased levels of NMF were observed. In doubtful reactions to FM I/II with negative breakdown testing, NMF was significantly lower than in petrolatum controls. PT reactions to thiurams and fragrances indicate a Th2-skewed inflammation. The inflammatory profiles suggest that weak or doubtful FM I/II reactions without accompanying reaction to a constituent were irritant. IL-16 might be suitable to distinguish irritant from allergic reaction. © 2020 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd. Brans Richard R https://orcid.org/0000-0002-1245-024X Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) at the University of Osnabrück, Osnabrück, Germany. Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany. Jakasa Ivone I Laboratory for Analytical Chemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia. Goc Sanja S Department for Immunochemistry and Glycobiology, Institute for the Application of Nuclear Energy - INEP, University of Belgrade, Belgrade, Serbia. John Swen M SM Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) at the University of Osnabrück, Osnabrück, Germany. Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany. Kezic Sanja S Coronel Institute of Occupational Health, Department of Public and Occupational Health, Amsterdam University Medical Centers, Amsterdam, The Netherlands. eng Journal Article 2020 12 13 England Contact Dermatitis 7604950 0105-1873 IM allergic contact dermatitis cytokines fragrances irritant mix natural moisturizing factor patch test rubber thiurams 2020 10 25 2020 08 05 2020 11 13 2020 11 23 6 0 2020 11 23 6 0 2020 11 22 20 46 ppublish 33222241 10.1111/cod.13746 REFERENCES, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>92.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Atypic large hepatic cyst with persistent elevated CA19.9 serum value: utility of intracystic CA72.4 dosage for a mini-invasive management.</a><a 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href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>The Acceptability and Influencing Factors of an Internet-Based Tinnitus Multivariate Integrated Sound Therapy for Patients With Tinnitus.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Lan T, Zhao F, Xiong B<br><font color=gray><i>Ear, nose, & throat journal, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>96.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Determination of outcomes of complex upper end tibial fractures in squatting and cross leg sitting South Asian population.</a><a 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M<br><font color=gray><i>BMC veterinary research, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>98.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Patch Testing to Diphenylguanidine by the North American Contact Dermatitis Group (2013-2016).</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Warshaw EM, Gupta R, Dekoven JG, Fowler JF, Silverberg JI, Atwater AR, Taylor JS, Reeder MJ, Maibach HI, Sasseville D, Belsito DV, DeLeo VA, Pratt MD, Marks JG, Zug KA, Zirwas MJ<br><font color=gray><i>Dermatitis : contact, atopic, occupational, drug, 2020</i></font><br><font 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lupus erythematosus patients: troublemaker or onlooker?</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Dubey S, Rodrigues C, Nikam C, Samant R<br><font color=gray><i>The Pan African medical journal, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br><br><br><table cellspacing=0 cellpadding=0 align=center><tr valign=bottom><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=9><img src=p.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=doubtful+knight%27s-spur&category=l&client=pubmed&startPage=1><img src=o_yellow.png border=0></a></td><td align=center><a 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