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Synonyms:
   Tylosis 

Broader Terms:
   Cerambycidae (longhorn beetles) 
   Trachyderina 

More Specific:
   Tylosis angusticollis 
   Tylosis argus 
   Tylosis bifasciata 
   Tylosis brevicollis 
   Tylosis conjuncta 
   Tylosis conjuncta parva 
   Tylosis dimidiata 
   Tylosis hilaris 
   Tylosis jimenezi 
   Tylosis jimenezii 
   Tylosis jiminezi 
   Tylosis maculata 
   Tylosis maculatus 
   Tylosis maculatus sellata 
   Tylosis medialis 
   Tylosis medialis bifasciata 
   Tylosis oculata 
   Tylosis oculatus 
   Tylosis puncticollis 
   Tylosis puncticollis angusticollis 
   Tylosis puncticollis arizonensis 
   Tylosis puncticollis arizonicus 
   Tylosis puncticollis hilaris 
   Tylosis puncticollis laeta 
   Tylosis puncticollis lćta 
   Tylosis puncticollis puncticollis 
   Tylosis robusta 
   Tylosis sellata 
   Tylosis sellatus 
   Tylosis sexualis 
   Tylosis subtruncata 
   Tylosis suturalis 
   Tylosis texana 
   Tylosis triangularis 
 
 
Latest Articles on Tylosis from uBioRSS
Ladybird with lunch - An Inordinate Fondness for Beetles Photo Pool
Therates latreillei (Thomson 1860) - An Inordinate Fondness for Beetles Photo Pool


External Resources:

Did you mean: Tylos or Tyloses?



1.  Palmoplantar keratoderma caused by a missense variant in CTSB encoding cathepsin B.LinkIT
Mohamad J, Samuelov L, Malki L, Peled A, Pavlovsky M, Malovitski K, Taiber S, Adir N, Rabinowitz T, Shomron N, Milner JD, Lestringant G, Sarig O, Sprecher E
Clinical and experimental dermatology Clin Exp Dermatol Palmoplantar keratoderma caused by a missense variant in CTSB encoding cathepsin B. 103-108 10.1111/ced.14384 Palmoplantar keratoderma (PPK) refers to a large group of disorders characterized by extensive genetic and phenotypic heterogeneity. PPK diagnosis therefore increasingly relies upon genetic analysis. To delineate the genetic defect underlying a case of diffuse erythematous PPK associated with peeling of the skin. Whole exome and direct sequencing, real-time quantitative PCR, protein modelling and a cathepsin B enzymatic assay were used. The patient studied had severe diffuse erythematous PPK transgrediens. Pedigree analysis suggested an autosomal dominant mode of inheritance. Whole exome sequencing revealed a heterozygous missense mutation in the CTSB gene, encoding the cysteine protease cathepsin B. Genomic duplications in a noncoding region, which regulates the expression of CTSB, were recently found to cause erythrokeratolysis hiemalis, a rare autosomal dominant disorder of cornification. This mutation affects a highly conserved residue, and is predicted to be pathogenic. Protein modelling indicated that the mutation is likely to lead to increased endopeptidase cathepsin B activity. Accordingly, the CTSB variant was found to result in increased cathepsin B proteolytic activity. In summary, we report the identification of the first gain-of-function missense mutation in CTSB, which was found to be associated in one individual with a dominant form of diffuse PPK. © 2020 British Association of Dermatologists. Mohamad J J Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Samuelov L L https://orcid.org/0000-0001-5387-5490 Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Malki L L Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Peled A A Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Pavlovsky M M Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. Malovitski K K Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Taiber S S Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Adir N N Schulich Faculty of Chemistry, Technion, Haifa, Israel. Rabinowitz T T Department of Cell and Developmental Biology, Tel Aviv University, Tel Aviv, Israel. Shomron N N Department of Cell and Developmental Biology, Tel Aviv University, Tel Aviv, Israel. Milner J D JD Department of Pediatrics, Columbia University, Irving Medical Center, New York, NY, USA. Lestringant G G Consultant Dermatologist (retired), British Ministry of Defence, London, UK. Sarig O O https://orcid.org/0000-0003-2987-2091 Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. Sprecher E E https://orcid.org/0000-0002-4093-1032 Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. eng Ram family donation Journal Article 2020 09 12 England Clin Exp Dermatol 7606847 0307-6938 IM 2019 12 30 2020 06 30 2020 07 15 2020 7 20 6 0 2020 7 20 6 0 2020 7 20 6 0 ppublish 32683719 10.1111/ced.14384 References, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>2.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Nagashima-Type Palmoplantar Keratosis with Compound Heterozygous Mutations in SERPINB7.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Songsantiphap C, Suwanwatana J, Ittiwut C, Asawanonda P, Rerknimitr P, Shotelersuk V<br><font color=gray><i>Case reports in dermatology, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>3.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>The Proteolytic Network in Palmoplantar Keratoderma: SERPINA12 Joins the Family.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Steele L, Tawfik SS, O'Toole EA<br><font color=gray><i>The Journal of investigative dermatology, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>4.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Increase in ring width, vessel number and ?18O in olive trees infected with Xylella fastidiosa.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Sabella E, Moretti S, Gärtner H, Luvisi A, De Bellis L, Vergine M, Saurer M, Cherubini P<br><font color=gray><i>Tree physiology, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>5.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Chao-Chu J, Murtough S, Zaman N, Pennington DJ, Blaydon DC, Kelsell DP<br><font color=gray><i>The Journal of investigative dermatology, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>6.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>A de novo mutation of KRT1 in a baby girl causing epidermolytic ichthyosis with impressive epidermolytic palmoplantar keratoderma.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Calì F, Failla P, Vinci M, Siragusa M, Schepis C<br><font color=gray><i>Dermatology online journal, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>7.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Diagnosis and Management of Inherited Palmoplantar Keratodermas.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Thomas BR, O'Toole EA<br><font color=gray><i>Acta dermato-venereologica, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>8.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Phenotypic Variability with SLURP1 Mutations and Diffuse Palmoplantar Keratoderma.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Harjama L, Kettunen K, Elomaa O, Einarsdottir E, Heikkilä H, Kivirikko S, Lappalainen K, Saarela J, Alby C, Ranki A, Kere J, Hadj-Rabia S, Hannula-Jouppi K<br><font color=gray><i>Acta dermato-venereologica, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>9.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Palmoplantar keratoderma, oral involvement, and homozygous CTSC mutation in two brothers from Cambodia.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Wei H, Wee LWY, Born B, Seang S, Koh MJA, Yee R, Lin G, Rafi'ee K, Mey S, Tan EC<br><font color=gray><i>American journal of medical genetics. Part A Am J Med Genet A Palmoplantar keratoderma, oral involvement, and homozygous CTSC mutation in two brothers from Cambodia. 296-302 10.1002/ajmg.a.61447 Haim-Munk syndrome (HMS) and Papillon-Lefevre syndrome (PLS) are phenotypic variants of palmoplantar keratoderma (PPK) with progressive early-onset periodontitis and dental caries. HMS and PLS have been associated with homozygous or compound heterozygous mutations in the lysosomal protease gene Cathepsin C (CTSC). There have been only a few documented cases of CTSC mutations in patients from South-East Asia. We report the clinical findings of two Cambodian brothers who presented with diffuse, demarcated PPK with transgrediens extending to the elbows and knees, as well as pachyonychia and dental caries. Arachnodactyly and periodontitis were also found in the older brother. Next-generation sequencing unveiled a homozygous missense variant in CTSC (NM_001814.5: c.1337AC: p.(Asp446Ala)) in both brothers. Both parents were heterozygous for the variant, while an unaffected older brother was homozygous for the wild-type allele. Our study adds to the spectrum of mutations and associated clinical presentations for this rare genodermatosis. © 2019 Wiley Periodicals, Inc. Wei Heming H Research Laboratory, KK Women's & Children's Hospital, Singapore. Wee Lynette W Y LWY Dermatology Service, KK Women's & Children's Hospital, Singapore. Born Bori B Department of Dermatology, Preah Kossamak Hospital, Phnom Penh, Cambodia. Seang Sokheng S Department of Dermatology, Preah Kossamak Hospital, Phnom Penh, Cambodia. Koh Mark J A MJA 0000-0002-4136-4105 Dermatology Service, KK Women's & Children's Hospital, Singapore. Paediatrics Academic Clinical Programme, SingHealth Duke-NUS Graduate Medical School, Singapore. Yee Ruixiang R Dental Service, KK Women's & Children's Hospital, Singapore. Lin Grace G Research Laboratory, KK Women's & Children's Hospital, Singapore. Rafi'ee Khadijah K Research Laboratory, KK Women's & Children's Hospital, Singapore. Mey Sithach S Department of Dermatology, Preah Kossamak Hospital, Phnom Penh, Cambodia. Tan Ene-Choo EC 0000-0001-5497-6058 Research Laboratory, KK Women's & Children's Hospital, Singapore. Paediatrics Academic Clinical Programme, SingHealth Duke-NUS Graduate Medical School, Singapore. eng NMRC/CG/M003/2017 National Medical Research Council International Case Reports Journal Article Research Support, Non-U.S. Gov't 2019 12 17 United States Am J Med Genet A 101235741 1552-4825 EC 3.4.14.1 CTSC protein, human EC 3.4.14.1 Cathepsin C Keratosis palmoplantaris with periodontopathia and onychogryposis IM Acro-Osteolysis diagnostic imaging epidemiology genetics physiopathology Adolescent Cambodia epidemiology Cathepsin C genetics Child Female Homozygote Humans Keratoderma, Palmoplantar diagnostic imaging epidemiology genetics physiopathology Male Mutation genetics Papillon-Lefevre Disease diagnostic imaging epidemiology genetics physiopathology Pedigree Siblings Haim-Munk syndrome Papillon-Lefevre syndrome cathepsin C palmoplantar keratoderma periodontitis 2019 09 19 2019 11 22 2019 11 26 2019 12 18 6 0 2021 1 12 6 0 2019 12 18 6 0 ppublish 31846207 10.1002/ajmg.a.61447 REFERENCES, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>10.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Keratin 9 L164P mutation in a Chinese pedigree with epidermolytic palmoplantar keratoderma, cytokeratin analysis, and literature review.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Liu X, Qiu C, He R, Zhang Y, Zhao Y<br><font color=gray><i>Molecular genetics & genomic medicine, 2019</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br><br><br><table cellspacing=0 cellpadding=0 align=center><tr 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