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Synonyms:
   Thunbergia bogoroensis 

Broader Terms:
   Thunbergia (Clock Vine) 
 
 


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41.  Andrographolide mitigates cardiac apoptosis to provide cardio-protection in high-fat-diet-induced obese mice.LinkIT
Lin KH, Marthandam Asokan S, Kuo WW, Hsieh YL, Lii CK, Viswanadha V, Lin YL, Wang S, Yang C, Huang CY
Environmental toxicology Environ Toxicol Andrographolide mitigates cardiac apoptosis to provide cardio-protection in high-fat-diet-induced obese mice. 707-713 10.1002/tox.22906 Excessive intake of high fat diet (HFD) and associated obese conditions are critical contributors of cardiac diseases. In this study, an active metabolite andrographolide from Andrographis paniculata was found to ameliorate HFD-induced cardiac apoptosis. C57/BL6 mouse were grouped as control (n = 9), obese (n = 8), low dose (25?mg/kg/d) andrographolide treatment (n = 9), and high dose (50?mg/kg/d) andrographolide treatment (n = 9). The control group was provided with standard laboratory chow and the other groups were fed with HFD. Andrographolide was administered through oral gavage for 1 week. Histopathological analysis showed increase in apoptotic nuclei and considerable cardiac-damages in the obese group signifying cardiac remodeling effects. Further, Western blot results showed increase in pro-apoptotic proteins and decrease in the proteins of IGF-1R-survival signaling. However, feeding of andrographolide significantly reduced the cardiac effects of HFD. The results strongly suggest that andrographolide supplementation can be used for prevention and treatment of cardiovascular disease in obese patients. © 2020 Wiley Periodicals, Inc. Lin Kuan-Ho KH College of Medicine, China Medical University, Taichung, Taiwan. Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan. Marthandam Asokan Shibu S Cardiovascular and Mitochondria Related Diseases Research Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. Kuo Wei-Wen WW https://orcid.org/0000-0002-2097-2240 Department of Biological Science and Technology, China Medical University, Taichung, Taiwan. Hsieh You-Liang YL Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan. Lii Chong-Kuei CK Department of Nutrition, China Medical University, Taichung, Taiwan. Viswanadha Vijayapadma V Department of Biotechnology, Bharathiar University, Coimbatore, India. Lin Yi-Lin YL Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan. Wang Shulin S Department of Cardiology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China. Yang Caixian C Department of Endocrinology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China. Huang Chih-Yang CY https://orcid.org/0000-0003-2347-0411 Cardiovascular and Mitochondria Related Diseases Research Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan. Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan. eng CMU103-ASIA-13 China Medical University and Asia University CMU107-ASIA-03 China Medical University and Asia University DMR-108-057 China Medical University Hospital Journal Article 2020 02 05 United States Environ Toxicol 100885357 1520-4081 0 Apoptosis Regulatory Proteins 0 Cardiovascular Agents 0 Diterpenes 410105JHGR andrographolide IM Andrographis chemistry Animals Apoptosis drug effects Apoptosis Regulatory Proteins metabolism Cardiovascular Agents isolation & purification pharmacology Diet, High-Fat adverse effects Diterpenes isolation & purification pharmacology Heart drug effects Male Mice Mice, Obese Myocardium metabolism pathology Obesity metabolism pathology physiopathology Signal Transduction Andrographis paniculata cardiac apoptosis cell survival high fat diet obesity 2019 05 20 2020 01 19 2020 01 20 2020 2 6 6 0 2020 6 17 6 0 2020 2 6 6 0 ppublish 32023008 10.1002/tox.22906 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