Pubmed    Pubmed Central		uBio Home | uBioRSS
WebSearch Literature Molecular Images

uBio  Web  Results 71 - 80 of about 1906 Synonyms:    Thunbergia bogoroensis  Broader Terms:    Thunbergia (Clock Vine)      External Resources: 71.  Andrographolide mitigates cardiac apoptosis to provide cardio-protection in high-fat-diet-induced obese mice. Lin KH, Marthandam Asokan S, Kuo WW, Hsieh YL, Lii CK, Viswanadha V, Lin YL, Wang S, Yang C, Huang CY Environmental toxicology Environ Toxicol Andrographolide mitigates cardiac apoptosis to provide cardio-protection in high-fat-diet-induced obese mice. 707-713 10.1002/tox.22906 Excessive intake of high fat diet (HFD) and associated obese conditions are critical contributors of cardiac diseases. In this study, an active metabolite andrographolide from Andrographis paniculata was found to ameliorate HFD-induced cardiac apoptosis. C57/BL6 mouse were grouped as control (n = 9), obese (n = 8), low dose (25?mg/kg/d) andrographolide treatment (n = 9), and high dose (50?mg/kg/d) andrographolide treatment (n = 9). The control group was provided with standard laboratory chow and the other groups were fed with HFD. Andrographolide was administered through oral gavage for 1 week. Histopathological analysis showed increase in apoptotic nuclei and considerable cardiac-damages in the obese group signifying cardiac remodeling effects. Further, Western blot results showed increase in pro-apoptotic proteins and decrease in the proteins of IGF-1R-survival signaling. However, feeding of andrographolide significantly reduced the cardiac effects of HFD. The results strongly suggest that andrographolide supplementation can be used for prevention and treatment of cardiovascular disease in obese patients. © 2020 Wiley Periodicals, Inc. Lin Kuan-Ho KH College of Medicine, China Medical University, Taichung, Taiwan. Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan. Marthandam Asokan Shibu S Cardiovascular and Mitochondria Related Diseases Research Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. Kuo Wei-Wen WW https://orcid.org/0000-0002-2097-2240 Department of Biological Science and Technology, China Medical University, Taichung, Taiwan. Hsieh You-Liang YL Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan. Lii Chong-Kuei CK Department of Nutrition, China Medical University, Taichung, Taiwan. Viswanadha Vijayapadma V Department of Biotechnology, Bharathiar University, Coimbatore, India. Lin Yi-Lin YL Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan. Wang Shulin S Department of Cardiology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China. Yang Caixian C Department of Endocrinology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China. Huang Chih-Yang CY https://orcid.org/0000-0003-2347-0411 Cardiovascular and Mitochondria Related Diseases Research Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan. Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan. eng CMU103-ASIA-13 China Medical University and Asia University CMU107-ASIA-03 China Medical University and Asia University DMR-108-057 China Medical University Hospital Journal Article 2020 02 05 United States Environ Toxicol 100885357 1520-4081 0 Apoptosis Regulatory Proteins 0 Cardiovascular Agents 0 Diterpenes 410105JHGR andrographolide IM Andrographis chemistry Animals Apoptosis drug effects Apoptosis Regulatory Proteins metabolism Cardiovascular Agents isolation & purification pharmacology Diet, High-Fat adverse effects Diterpenes isolation & purification pharmacology Heart drug effects Male Mice Mice, Obese Myocardium metabolism pathology Obesity metabolism pathology physiopathology Signal Transduction Andrographis paniculata cardiac apoptosis cell survival high fat diet obesity 2019 05 20 2020 01 19 2020 01 20 2020 2 6 6 0 2020 6 17 6 0 2020 2 6 6 0 ppublish 32023008 10.1002/tox.22906 J Pharm Pharmacol Standardized Xylocarpus moluccensis fruit fraction mitigates collagen-induced arthritis in mice by regulating immune response. 619-632 10.1111/jphp.13231 This study was undertaken to evaluate the effect of Xylocarpus moluccensis fruit fraction (F018) on the pathogenesis of collagen-induced arthritis in mice. Arthritis was induced by intradermal injection of collagen (2 mg/ml) with complete Freund's adjuvant in DBA/1J mice. F018 was administered orally at 1, 3 and 10 mg/kg for 20 days. Disease progression and mechanism were assessed by micro-CT analysis, RT-PCR, flow cytometry assay, myeloperoxidase (MPO) and MTT assay. F018 at 3 and 10 mg/kg significantly reduced paw thickness, clinical score, mononuclear cell infiltration and collagen layer depletion in the knee section of collagen-induced arthritis (CIA) mice when compared with collagen-induced arthritis mice alone. Furthermore, F018 treatment in collagen-induced arthritis mice significantly recovered bone volume and trabecular number and decreased the trabecular space by modulating RANKL and OPG mRNA expression in the synovial tissue. F018 treatment in collagen-induced arthritis mice significantly attenuated spleen index, lymphocyte proliferation and paw myeloperoxidase (MPO) activity, pro-inflammatory cytokine TNF?, IL1?, and IL6 mRNA expression and enhanced IL10 mRNA expression in paw tissue. Furthermore, F018 treatment in collagen-induced arthritis mice significantly reduced splenic dendritic cell maturation and Th17 cells. In culture, F018 significantly decreased collagen-induced arthritis-FLS proliferation and promoted apoptosis. F018 may serve as a potential curative agent for arthritis. © 2020 Royal Pharmaceutical Society. Gupta Priya P Division of Pharmacology, Council of Scientific and Industrial Research-Central Drug Research Institute (CSIR-CDRI), Lucknow, India. Kumar Amit A Division of Pharmacology, Council of Scientific and Industrial Research-Central Drug Research Institute (CSIR-CDRI), Lucknow, India. Pal Subhashis S Division of Endocrinology, Council of Scientific and Industrial Research-Central Drug Research Institute (CSIR-CDRI), Lucknow, India. Kumar Sachin S Division of Pharmacology, Council of Scientific and Industrial Research-Central Drug Research Institute (CSIR-CDRI), Lucknow, India. Lahiri Amit A Division of Pharmacology, Council of Scientific and Industrial Research-Central Drug Research Institute (CSIR-CDRI), Lucknow, India. Kumaravelu Jagavelu J Division of Pharmacology, Council of Scientific and Industrial Research-Central Drug Research Institute (CSIR-CDRI), Lucknow, India. Chattopadhyay Naibedya N Division of Endocrinology, Council of Scientific and Industrial Research-Central Drug Research Institute (CSIR-CDRI), Lucknow, India. Dikshit Madhu M Division of Pharmacology, Council of Scientific and Industrial Research-Central Drug Research Institute (CSIR-CDRI), Lucknow, India. Barthwal Manoj Kumar MK https://orcid.org/0000-0001-7574-482X Division of Pharmacology, Council of Scientific and Industrial Research-Central Drug Research Institute (CSIR-CDRI), Lucknow, India. eng MoES Journal Article 2020 02 09 England J Pharm Pharmacol 0376363 0022-3573 0 Cytokines 0 Plant Extracts 9007-34-5 Collagen IM Acanthaceae chemistry Animals Apoptosis drug effects Arthritis, Experimental chemically induced drug therapy Bone and Bones drug effects Cell Proliferation drug effects Collagen pharmacology Cytokines metabolism Edema chemically induced Fibroblasts drug effects Fruit Immunity drug effects Inflammation Joints drug effects Lymphocytes drug effects Male Mice Mice, Inbred DBA Plant Extracts pharmacokinetics Wetlands Xylocarpus moluccensis Th17 cell collagen-induced arthritis dendritic cell fibroblast-like synoviocyte lymphocyte 2019 10 22 2020 01 01 2020 2 11 6 0 2021 1 5 6 0 2020 2 11 6 0 ppublish 32037560 10.1111/jphp.13231