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uBio  Web  Results 131 - 140 of about 1906 Synonyms:    Thunbergia bogoroensis  Broader Terms:    Thunbergia (Clock Vine)      External Resources: 131.  Isolates from Monechma ciliatum seeds' extract hampered Porphyromonas gingivalis hemagglutinins. Eltigani SA, Eltayeb MM, Ishihara A, Arima J Journal of food biochemistry J Food Biochem Isolates from Monechma ciliatum seeds' extract hampered Porphyromonas gingivalis hemagglutinins. e13029 10.1111/jfbc.13029 Porphyromonas gingivalis is a major periodontitis pathogen that produces several virulence factors including hemagglutinins. These proteins, which are vital molecules, allow P. gingivalis to uptake iron and heme by attaching, aggregating, and lysing erythrocytes. In this study, we evaluated the inhibitory activity of the aqueous extract of Monechma ciliatum seeds against the hemagglutination activity of P. gingivalis. M. ciliatum is a Sudanese medicinal herb that grows in arid and semi-arid lands of tropical Africa. The water extracted from dry powdered seeds was partitioned using ethyl acetate followed by reversed-phase chromatography, thin-layer chromatography, ESI-MS, and NMR analysis resulting in the isolation of four compounds identified as oleic acid, coumarin, 1,2-dioleoylglycerol, and 1,3-dioleoylglycerol with MICs of 15-100 ?g/ml against hemagglutination. We believe that the isolation and purification of these compounds will expand the application of M. ciliatum as a natural therapeutic or preventative agent. PRACTICAL APPLICATIONS: Monechma ciliatum or black mahlab is a famous medicinal plant that grows in some parts of arid and semi-arid areas of tropical Africa including western Sudan. Despite its nutritional and traditional medical applications, no studies have evaluated its anti-hemagglutination activity against periodontal pathogens. In this study, four active compounds (oleic acid, coumarin, 1,2-dioleoylglycerol, and 1,3-dioleoylglycerol) were isolated and identified from an aqueous extract of M. ciliatum seeds. The isolated compounds revealed high levels of inhibitory activity against all hemagglutinin agents secreted by Porphyromonas gingivalis. This evidence of inhibitory activity will encourage the application of M. ciliatum effectively as a functional food or therapeutic agent to prevent periodontal diseases in the early stages. © 2019 Wiley Periodicals, Inc. Eltigani Sara A SA The United Graduate School of Agricultural Sciences, Tottori University, Tottori, Japan. Eltayeb Mohamed M MM Arid Land Research Center, Tottori University, Tottori, Japan. Department of Food Science and Technology, Faculty of Agriculture, University of Khartoum, Khartoum, Sudan. Ishihara Atsushi A Department of Agricultural, Life and Environmental Sciences, Faculty of Agriculture, Tottori University, Tottori, Japan. Arima Jiro J 0000-0002-6552-8397 Department of Agricultural, Life and Environmental Sciences, Faculty of Agriculture, Tottori University, Tottori, Japan. eng Journal Article 2019 08 29 United States J Food Biochem 7706045 0145-8884 0 Anti-Bacterial Agents 0 Bacterial Proteins 0 Hemagglutinins 0 Plant Extracts 42VZT0U6YR Heme IM Acanthaceae chemistry Anti-Bacterial Agents chemistry isolation & purification pharmacology Bacterial Proteins antagonists & inhibitors genetics metabolism Hemagglutination Tests Hemagglutinins genetics metabolism Heme metabolism Plant Extracts chemistry isolation & purification pharmacology Porphyromonas gingivalis drug effects genetics metabolism Seeds chemistry Sudan Monechma ciliatum Porphyromonas gingivalis aqueous extract hemagglutinins 2019 06 17 2019 08 12 2019 08 13 2019 8 30 6 0 2020 9 18 6 0 2019 8 30 6 0 ppublish 31465126 10.1111/jfbc.13029