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Synonyms:
   Ctenotrypauchen microcephalus (Blind goby) 
   Taeniodes microcephalus 

Broader Terms:
   Taeniodes (sharptooth worm gobies) 
 
 


External Resources:



1.  Mutation in CEP135 causing primary microcephaly and subcortical heterotopia.LinkIT
Bamborschke D, Daimagüler HS, Hahn A, Hussain MS, Nürnberg P, Cirak S
American journal of medical genetics. Part A Am. J. Med. Genet. A Mutation in CEP135 causing primary microcephaly and subcortical heterotopia. 10.1002/ajmg.a.61762 Bamborschke Daniel D https://orcid.org/0000-0002-9868-0184 Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. Daimagüler Hülya-Sevcan HS Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. Hahn Andreas A Department of Child Neurology, Justus-Liebig-University Giessen, Giessen, Germany. Hussain Muhammad S MS Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany. Institute of Biochemistry I, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. Nürnberg Peter P Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany. Cirak Sebahattin S Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. eng CI 218/1-1 Deutsche Forschungsgemeinschaft (DFG) Letter 2020 07 09 United States Am J Med Genet A 101235741 1552-4825 IM CEP135 neuronal migration defect primary microcephaly subcortical heterotopia 2020 04 04 2020 06 12 2020 06 13 2020 7 10 6 0 2020 7 10 6 0 2020 7 10 6 0 aheadofprint 32643282 10.1002/ajmg.a.61762 REFERENCES, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>2.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Zika epidemic and microcephaly in Brazil: Challenges for access to health care and promotion in three epidemic areas.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Peiter PC, Pereira RDS, Nunes Moreira MC, Nascimento M, Tavares MFL, Franco VDC, Carvajal Cortês JJ, Campos DS, Barcellos C<br><font color=gray><i>PloS one, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>3.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>The EJC component Magoh in non-vertebrate chordates.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Sepe RM, Ghiron JHL, Zucchetti I, Caputi L, Tarallo R, Crocetta F, De Santis R, D'Aniello S, Sordino P<br><font color=gray><i>Development genes and evolution, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>4.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Evolution of EEG Findings in Pontocerebellar Hypoplasia Type 2A: Normal EEG in the First Few Months followed by Abnormal Tracing over the Years.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Cohen R, Goldberg-Stern H, Kivity S, Halevy A, Aharoni S, Kornreich L, Straussberg R<br><font color=gray><i>Neuropediatrics, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>5.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Zika virus NS1 affects the junctional integrity of human brain microvascular endothelial cells.</ArticleTitle> <ELocationID EIdType="pii" ValidYN="Y">S0300-9084(20)30151-6</ELocationID> <ELocationID EIdType="doi" ValidYN="Y">10.1016/j.biochi.2020.06.011</ELocationID> <Abstract> <AbstractText>Zika virus (ZIKV) infection leads to microcephaly in newborns. Flaviviruses are known to secrete NS1 protein extracellularly and its concentration in serum directly co-relate to disease severity. The presence of ZIKV-NS1 near the brain microvascular endothelial cells (BMVECs) affects blood-brain-barrier, which is composed of tight junctions (TJs) and adherens junctions (AJs). Viruses utilize different strategies to circumvent this barrier to enter in brain. The present study demonstrated the mechanism of junctional integrity disruption in BMVECs by ZIKV-NS1 protein exposure. The Transendothelial Electrical Resistance and sodium fluorescein migration assays revealed the endothelial barrier disruption in BMVECs exposed to ZIKV-NS1 at different time (12hr and 24hr) and doses (500?ng/mL, 1000?ng/mL and 1500?ng/mL). The exposure of ZIKV-NS1 on BMVECs led to the phosphorylation of AJs and suppression of TJs through secreted ZIKV-NS1 in a bystander fashion. The activation of NADPH dependent reactive oxygen species activity and redox sensitive tyrosine kinase further increased the phosphorylation of AJs. The reduced expression of the phosphatase led to the increased phosphorylation of the AJs. The treatment with Diphenyleneiodonium chloride rescued the phosphatase and TJs expression and suppressed the expression of kinase and AJs in BMVECs exposed to ZIKV-NS1.</AbstractText> <CopyrightInformation>Copyright © 2020. Published by Elsevier B.V.</CopyrightInformation> </Abstract> <AuthorList CompleteYN="Y"> <Author ValidYN="Y"> <LastName>Rastogi</LastName> <ForeName>Meghana</ForeName> <Initials>M</Initials> <AffiliationInfo> <Affiliation>Molecular Biology Unit, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, U.P, India.</Affiliation> </AffiliationInfo> </Author> <Author ValidYN="Y"> <LastName>Singh</LastName> <ForeName>Sunit K</ForeName> <Initials>SK</Initials> <AffiliationInfo> <Affiliation>Molecular Biology Unit, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, U.P, India. Electronic address: sunitsingh2000@gmail.com.</Affiliation> </AffiliationInfo> </Author> </AuthorList> <Language>eng</Language> <PublicationTypeList> <PublicationType UI="D016428">Journal Article</PublicationType> </PublicationTypeList> <ArticleDate DateType="Electronic"> <Year>2020</Year> <Month>07</Month> <Day>05</Day> </ArticleDate> </Article> <MedlineJournalInfo> <Country>France</Country> <MedlineTA>Biochimie</MedlineTA> <NlmUniqueID>1264604</NlmUniqueID> <ISSNLinking>0300-9084</ISSNLinking> </MedlineJournalInfo> <CitationSubset>IM</CitationSubset> <KeywordList Owner="NOTNLM"> <Keyword MajorTopicYN="N">Adherens junctions and tight junctions</Keyword> <Keyword MajorTopicYN="N">Blood-brain-barrier</Keyword> <Keyword MajorTopicYN="N">Brain microvascular endothelial cells (BMVECs)</Keyword> <Keyword MajorTopicYN="N">Zika virus NS1 protein</Keyword> </KeywordList> <CoiStatement>Declaration of competing interest The authors declare they have no conflict of interest.</CoiStatement> </MedlineCitation> <PubmedData> <History> <PubMedPubDate PubStatus="received"> <Year>2020</Year> <Month>05</Month> <Day>12</Day> </PubMedPubDate> <PubMedPubDate PubStatus="revised"> <Year>2020</Year> <Month>06</Month> <Day>25</Day> </PubMedPubDate> <PubMedPubDate PubStatus="accepted"> <Year>2020</Year> <Month>06</Month> <Day>29</Day> </PubMedPubDate> <PubMedPubDate PubStatus="entrez"> <Year>2020</Year> <Month>7</Month> <Day>9</Day> <Hour>6</Hour> <Minute>0</Minute> </PubMedPubDate> <PubMedPubDate PubStatus="pubmed"> <Year>2020</Year> <Month>7</Month> <Day>9</Day> <Hour>6</Hour> <Minute>0</Minute> </PubMedPubDate> <PubMedPubDate PubStatus="medline"> <Year>2020</Year> <Month>7</Month> <Day>9</Day> <Hour>6</Hour> <Minute>0</Minute> </PubMedPubDate> </History> <PublicationStatus>aheadofprint</PublicationStatus> <ArticleIdList> <ArticleId IdType="pubmed">32640279</ArticleId> <ArticleId IdType="pii">S0300-9084(20)30151-6</ArticleId> <ArticleId IdType="doi">10.1016/j.biochi.2020.06.011</ArticleId> </ArticleIdList> </PubmedData></PubmedArticle><PubmedBookArticle> <BookDocument> <PMID Version="1">32644417</PMID> <ArticleIdList> <ArticleId IdType="bookaccession">NBK558991</ArticleId> </ArticleIdList> <Book> <Publisher> <PublisherName>StatPearls Publishing</PublisherName> <PublisherLocation>Treasure Island (FL)</PublisherLocation> </Publisher> <BookTitle book="statpearls">StatPearls</BookTitle> <PubDate> <Year>2020</Year> <Month>01</Month> </PubDate> <BeginningDate> <Year>2020</Year> <Month>01</Month> </BeginningDate> <Medium>Internet</Medium> </Book> <ArticleTitle book="statpearls" part="article-23064">Hydranencephaly</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Rastogi M, Singh SK, , Sandoval JI, De Jesus O<br><font color=gray><i>Biochimie, 2020</Year> <Month>Jul</Month> <Day>05</Day> </PubDate> </JournalIssue> <Title>Biochimie Biochimie Zika virus NS1 affects the junctional integrity of human brain microvascular endothelial cells. S0300-9084(20)30151-6 10.1016/j.biochi.2020.06.011 Zika virus (ZIKV) infection leads to microcephaly in newborns. Flaviviruses are known to secrete NS1 protein extracellularly and its concentration in serum directly co-relate to disease severity. The presence of ZIKV-NS1 near the brain microvascular endothelial cells (BMVECs) affects blood-brain-barrier, which is composed of tight junctions (TJs) and adherens junctions (AJs). Viruses utilize different strategies to circumvent this barrier to enter in brain. The present study demonstrated the mechanism of junctional integrity disruption in BMVECs by ZIKV-NS1 protein exposure. The Transendothelial Electrical Resistance and sodium fluorescein migration assays revealed the endothelial barrier disruption in BMVECs exposed to ZIKV-NS1 at different time (12hr and 24hr) and doses (500?ng/mL, 1000?ng/mL and 1500?ng/mL). The exposure of ZIKV-NS1 on BMVECs led to the phosphorylation of AJs and suppression of TJs through secreted ZIKV-NS1 in a bystander fashion. The activation of NADPH dependent reactive oxygen species activity and redox sensitive tyrosine kinase further increased the phosphorylation of AJs. The reduced expression of the phosphatase led to the increased phosphorylation of the AJs. The treatment with Diphenyleneiodonium chloride rescued the phosphatase and TJs expression and suppressed the expression of kinase and AJs in BMVECs exposed to ZIKV-NS1. Copyright © 2020. Published by Elsevier B.V. Rastogi Meghana M Molecular Biology Unit, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, U.P, India. Singh Sunit K SK Molecular Biology Unit, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, U.P, India. Electronic address: sunitsingh2000@gmail.com. eng Journal Article 2020 07 05 France Biochimie 1264604 0300-9084 IM Adherens junctions and tight junctions Blood-brain-barrier Brain microvascular endothelial cells (BMVECs) Zika virus NS1 protein Declaration of competing interest The authors declare they have no conflict of interest. 2020 05 12 2020 06 25 2020 06 29 2020 7 9 6 0 2020 7 9 6 0 2020 7 9 6 0 aheadofprint 32640279 S0300-9084(20)30151-6 10.1016/j.biochi.2020.06.011 32644417 NBK558991 StatPearls Publishing Treasure Island (FL) StatPearls 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

6.  Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development.LinkIT
Archambault D, Cheong A, Iverson E, Tremblay KD, Mager J
Developmental biology, 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

7.  Association Between Antenatal Exposure to Zika Virus and Anatomical and Neurodevelopmental Abnormalities in Children.LinkIT
Cranston JS, Tiene SF, Nielsen-Saines K, Vasconcelos Z, Pone MV, Pone S, Zin A, Salles TS, Pereira JP, Orofino D, Brasil P, Kerin T, Adachi K, Soares FM, Dunshee de Abranches A, da Costa ACC, Lopes Moreira ME
JAMA network open, 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

8.  A complex between the Zika virion and the Fab of a broadly cross-reactive neutralizing monoclonal antibody revealed by cryo-EM and single particle analysis at 4.1 Å resolution.LinkIT
Tyagi A, Ahmed T, Shi J, Bhushan S
Journal of structural biology: X, 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

9.  Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/?-catenin signaling.LinkIT
Sun X, Zhang R, Chen H, Du X, Chen S, Huang J, Liu M, Xu M, Luo F, Jin M, Su N, Qi H, Yang J, Tan Q, Zhang D, Ni Z, Liang S, Zhang B, Chen D, Zhang X, Luo L, Chen L, Xie Y
Theranostics, 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0



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