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Broader Terms:
   Lamiales 
   Scrophulariaceae (figworts) 
   Scrophulariales 

More Specific:
   Acanthorrhinum 
   Achetaria 
   Achizosepala 
   Adenosma 
   Adenostegia 
   Agalinis (false foxglove) 
   Agathelpis 
   Albraunia 
   Alectra 
   Alicosta 
   Allocalyx 
   Allopleia 
   Alonsoa (Mask Flower) 
   Amalophyllon 
   Ambuli 
   Amphianthus (amphianthus) 
   Amphiolanthus 
   Anagalloides 
   Anagosperma 
   Anamaria 
   Anarrhinum 
   Anastrabe 
   Ancistrostylis 
   Angelonia (angelon) 
   Anisantherina 
   Antherothamnus 
   Anticharis 
   Antirrhinum (snapdragon) 
   Antrizon 
   Apentostera 
   Aphyllon 
   Aponoa 
   Aptosimeae 
   Aptosimum 
   Aragoa 
   Artanema 
   Asarina 
   Aulaya 
   Aureolaria (false foxglove) 
   Auriolaria 
   AÔdelus 
   Bacopa (water hyssop) 
   Bahel 
   Bampsia 
   Barthlottia 
   Bartsia 
   Basistemon 
   Baumia 
   Bazina 
   Becabunga 
   Bellardia (lineseed) 
   Benjaminia 
   Benthamistella 
   Berendtia 
   Berendtiella 
   Besseya (kittentail) 
   Bonarota 
   Bonnaya 
   Bonnayodes 
   Borckhausenia 
   Bornmuellerantha 
   Botryopleuron 
   Bovea 
   Bowkeria 
   Brachycorys 
   Brachygyne 
   Brachystigma (desert foxglove) 
   Brami 
   Bramia 
   Brandisia 
   Braunblanquetia 
   Brookea 
   Bryodes 
   Buchnera (bluehearts) 
   Buddlejeae 
... 
 
Latest Articles on Scrophulariaceae from uBioRSS
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Common Names: speedwell family, figworts, scrofulaires, figwort family, figwort



1.  The biosynthesis of the anti-microbial diterpenoid leubethanol in Leucophyllum frutescens proceeds via an all-cis prenyl intermediate.LinkIT
Miller GP, Bhat WW, Lanier ER, Johnson SR, Mathieu DT, Hamberger B
The Plant journal : for cell and molecular biology Plant J The biosynthesis of the anti-microbial diterpenoid leubethanol in Leucophyllum frutescens proceeds via an all-cis prenyl intermediate. 693-705 10.1111/tpj.14957 Serrulatane diterpenoids are natural products found in plants from a subset of genera within the figwort family (Scrophulariaceae). Many of these compounds have been characterized as having anti-microbial properties and share a common diterpene backbone. One example, leubethanol from Texas sage (Leucophyllum frutescens) has demonstrated activity against multi-drug-resistant tuberculosis. Leubethanol is the only serrulatane diterpenoid identified from this genus; however, a range of such compounds have been found throughout the closely related Eremophila genus. Despite their potential therapeutic relevance, the biosynthesis of serrulatane diterpenoids has not been previously reported. Here we leverage the simple product profile and high accumulation of leubethanol in the roots of L.¬†frutescens and compare tissue-specific transcriptomes with existing data from Eremophila serrulata to decipher the biosynthesis of leubethanol. A short-chain cis-prenyl transferase (LfCPT1) first produces the rare diterpene precursor nerylneryl diphosphate, which is cyclized by an unusual plastidial terpene synthase (LfTPS1) into the characteristic serrulatane diterpene backbone. Final conversion to leubethanol is catalyzed by a cytochrome P450 (CYP71D616) of the CYP71 clan. This pathway documents the presence of a short-chain cis-prenyl diphosphate synthase, previously only found in Solanaceae, which is likely involved in the biosynthesis of other known diterpene backbones in Eremophila. LfTPS1 represents neofunctionalization of a compartment-switching terpene synthase accepting a novel substrate in the plastid. Biosynthetic access to leubethanol will enable pathway discovery to more complex serrulatane diterpenoids which share this common starting structure and provide a platform for the production and diversification of this class of promising anti-microbial therapeutics in heterologous systems. ¬© 2020 The Authors. The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd. Miller Garret P GP https://orcid.org/0000-0002-0222-0184 Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA. Bhat Wajid Waheed WW https://orcid.org/0000-0002-7049-8671 Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA. Lanier Emily R ER https://orcid.org/0000-0002-1878-4566 Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA. Johnson Sean R SR https://orcid.org/0000-0001-8261-9015 Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA. Mathieu Davis T DT Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA. Hamberger Bj√∂rn B https://orcid.org/0000-0003-1249-1807 Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA. eng DGE-1848739 National Science Foundation T32 GM110523 GM NIGMS NIH HHS United States T32-GM110523 Foundation for the National Institutes of Health 1737898 National Science Foundation SPG Evolutionary-Driven Genome Mining of Plant Bio Michigan State University SPG Plant-Inspired Chemical Diversity Michigan State University MICL02454 Michigan State University Journal Article 2020 08 28 England Plant J 9207397 0960-7412 IM all-cis prenyl diphosphate anti-microbial cytochrome P450 leubethanol terpene biosynthesis 2020 03 15 2020 06 17 2020 07 16 2020 8 11 6 0 2020 8 11 6 0 2020 8 11 6 0 ppublish 32777127 10.1111/tpj.14957 References, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>2.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>First Report of Powdery Mildew on <i>Leucophyllum frutescens</i> Caused by <i>Podosphaera xanthii</i> in Mexico.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Beltr√°n-Pe√Īa H, Felix-Gastelum R, Camacho-Tapia M, C Correia K, Herrera-Rodriguez G, Garcia-Estrada RS, Tovar-Pedraza JM<br><font color=gray><i>Plant disease, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>3.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Taxonomic implication of leaf epidermal anatomy of selected taxa of <b>Scrophulariaceae</b> from Pakistan.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Ullah F, Ayaz A, Saqib S, Parmar G, Bahadur S, Zaman W<br><font color=gray><i>Microscopy research and technique Microsc Res Tech Taxonomic implication of leaf epidermal anatomy of selected taxa of Scrophulariaceae from Pakistan. 10.1002/jemt.23608 The family Scrophulariaceae consists of taxonomically complex genera and species. The delimitation of the taxa within this family is always challenging. In this paper, we studied leaf epidermis anatomical characteristics and its taxonomic significance of four species belonging to four genera of the family Scrophulariaceae collected from northern Pakistan. The species were examined under light and scanning electron microscopes (LM and SEM). Qualitative and quantitative foliar epidermal anatomical features were examined for both adaxial and abaxial surfaces. Qualitative characters like epidermal cell shape, epidermal cell cover, anticlinal wall, trichomes type, stomata type and stomata position were examined. Quantitative characters like the length and width of leaf epidermis, stomata, stomatal pore, subsidiary cell and trichomes for both adaxial and abaxial surfaces were studied and measured. Stomatal index within the species and between the species was found to be different on adaxial and abaxial surfaces. Diacytic stomata and glandular trichomes on epidermis were only found in Anticharis glandulosa while rest of the taxa has anomocytic type stomata and dendroid trichomes on both surfaces. Based on the micromorphological characters, we did principal component analysis (PCA), and cluster analysis for the species delimitation and identification. A taxonomic key has been provided to delimit and identify the studied taxa based on foliar epidermal characters. The aim of the present research was to elucidate the micromorphological characters to distinguish the studied taxa for taxonomic purposes. ¬© 2020 Wiley Periodicals LLC. Ullah Fazal F https://orcid.org/0000-0001-5856-3189 CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China. University of Chinese Academy of Sciences, Beijing 100049, China. Ayaz Asma A https://orcid.org/0000-0002-7596-8513 State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, China. Saqib Saddam S University of Chinese Academy of Sciences, Beijing 100049, China. State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Beijing, China. Parmar Gaurav G University of Chinese Academy of Sciences, Beijing 100049, China. State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Beijing, China. Bahadur Saraj S https://orcid.org/0000-0002-5496-7861 College of Forestry, Hainan University, Haikou, China. Zaman Wajid W https://orcid.org/0000-0001-6864-2366 University of Chinese Academy of Sciences, Beijing 100049, China. State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Beijing, China. eng Journal Article 2020 09 29 United States Microsc Res Tech 9203012 1059-910X IM PCA SEM Scrophulariaceae leaf micromorphology trichomes diversity 2020 08 05 2020 09 06 2020 09 14 2020 9 29 9 23 2020 9 30 6 0 2020 9 30 6 0 aheadofprint 32990330 10.1002/jemt.23608 REFERENCES, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>4.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Fufang Xueshuantong alleviates diabetic retinopathy by activating the PPAR signalling pathway and complement and coagulation cascades.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Sun HH, Chai XL, Li HL, Tian JY, Jiang KX, Song XZ, Wang XR, Fang YS, Ji Q, Liu H, Hao GM, Wang W, Han J<br><font color=gray><i>Journal of ethnopharmacology, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>5.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>A review on the structure and pharmacological activity of phenylethanoid glycosides.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Tian XY, Li MX, Lin T, Qiu Y, Zhu YT, Li XL, Tao WD, Wang P, Ren XX, Chen LP<br><font color=gray><i>European journal of medicinal chemistry, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>6.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Phytochemistry of <i>Verbascum</i> Species Growing in Iraqi Kurdistan and Bioactive Iridoids from the Flowers of <i>Verbascum calvum</i>.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>M Amin HI, Hussain FHS, Gilardoni G, Thu ZM, Clericuzio M, Vidari G<br><font color=gray><i>Plants (Basel, Switzerland), 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>7.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Origin of the critically endangered endemic species Scrophularia takesimensis (<b>Scrophulariaceae</b>) on Ulleung Island, Korea: implications for conservation.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Gil HY, Maki M, Pimenova EA, Taran A, Kim SC<br><font color=gray><i>Journal of plant research, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>8.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Data on identification of primary and secondary metabolites in aqueous extract of <i>Verbascum betonicifolium</i>.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Serralheiro ML, Guedes R, Fadel SR, Bendif H<br><font color=gray><i>Data in brief, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>9.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Comparative morphology of myrmecophilous immature stages of European Microdon species (Diptera: Syrphidae): updated identification key and new diagnostic characters.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Scarparo G, Wolton R, Molfini M, Pinna LC, Giulio AD<br><font color=gray><i>Zootaxa, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>10.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Phytochemical Analysis and Various Biological Activities of the Aerial Parts of <i>Scrophularia Atropatana</i> Growing in Iran.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Asnaashari S, Delazar A, Safarzadeh E, Tabibi H, Mollaei S, Rajabi A, Asgharian P<br><font color=gray><i>Iranian journal of pharmaceutical research : IJPR, 2019</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br><br><br><table cellspacing=0 cellpadding=0 align=center><tr valign=bottom><td align=center><img src=p.png border=0></td><td align=center><img src=o_red.png border=0></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=2><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=3><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=4><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=5><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=6><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=7><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=8><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=9><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=10><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=2><img src=rtal.png border=0></a></td></tr><td align=center></td><td align=center>1</td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=2>2</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=3>3</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=4>4</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=5>5</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=6>6</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=7>7</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=8>8</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=9>9</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=10>10</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Scrophulariaceae&category=l&client=pubmed&startPage=2>¬Ľ</a></td></tr></table></table></tr></table></td><script src="http://www.google-analytics.com/urchin.js" type="text/javascript"> </script> <script type="text/javascript"> _uacct = "UA-634822-1"; urchinTracker(); </script> </BODY> </HTML>