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uBio  Web  Results 141 - 150 of about 3578 Synonyms:    Oncidium carthaginense (Coot Bay dancing-lady orchid)  Broader Terms:    Oncidium (Dancing ladies)     Orchidales  More Specific:    Oncidium carthaginense andreanum     Oncidium carthaginense klotzschii     Oncidium carthaginense oerstedii     Oncidium carthaginense sanguineum     Oncidium carthaginense swartzii      External Resources: Common Names: Coot Bay dancing-lady orchid 141.  Discovery and identification of proangiogenic chemical markers from Gastrodiae Rhizoma based on zebrafish model and metabolomics approach. Liu M, Zhao L, Han L, Li H, Shi Y, Cui J, Wang C, Xu L, Zhong L Phytochemical analysis : PCA Phytochem Anal Discovery and identification of proangiogenic chemical markers from Gastrodiae Rhizoma based on zebrafish model and metabolomics approach. 835-845 10.1002/pca.2949 Angiogenesis is closely related to a variety of diseases, and therapies based on angiogenesis are intensely investigated. Studies have shown that the use of Gastrodiae Rhizoma (GR, Gastrodia elata) can benefit the treatment of ischemic cardiovascular diseases and atherosclerosis by stimulating angiogenesis. This study tested the angiogenesis effects of a group of chemical markers isolated from GR. Zebrafish model was used to evaluate angiogenesis by setting four groups: blank control group, model group, positive control group and treatment group (0.1, 1, and 100 ?g/mL RGP). The Gray correlation analysis (GCA) was implemented to calculate the correlation coefficients of each compound between the peak area in liquid chromatography time-of-flight mass spectrometry (LC-TOF-MS) and the bioactivity, the top ten components with the correlation degree > 0.9 were listed. The optimum final concentration of GR on proangiogenesis effect was determined to be 100 ?g/mL. Ten compounds, including gastrodin, parishin E, stigmasterol, p-hydroxybenzyl alcohol, citric acid, etc., were identified to have high correlation coefficients with proangiogenic activity. Furthermore, the network pharmacologic analysis of these compounds revealed that the compounds systematically regulate the formation of new blood vessels via networked vital targets and signalling pathways. GR can promote the growth of blood vessels, ten chemical components discovered contribute to this proangiogenesis activity. These chemical markers of GR thus provide a foundation for further studies on medicinal substances and quality evaluation of GR, also providing a scientific basis for modern interpretation of the processing theory of traditional Chinese medicine. © 2020 John Wiley & Sons, Ltd. Liu Mengyujie M Department of Pharmacy, Qilu Hospital of Shandong University, Jinan, China. Zhao Liang L Department of Pharmacy, Qilu Hospital of Shandong University, Jinan, China. Han Liwen L Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China. Li Haonan H Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China. Shi Yongping Y Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China. Cui Jing J Department of Pharmacy, Qilu Hospital of Shandong University, Jinan, China. Wang Chenyang C Department of Pharmacy, Qilu Hospital of Shandong University, Jinan, China. Xu Li L Department of Pharmacy, Qilu Hospital of Shandong University, Jinan, China. Zhong Lihong L https://orcid.org/0000-0003-2998-1490 Department of Pharmacy, Qilu Hospital of Shandong University, Jinan, China. eng 2060302 Key project at central government level: The ability establishment of sustainable use for valuable Chinese medicine resources 81903479 National Natural Science Foundation of China Youth Project ZR2019MH037 Natural Science Foundation of Shandong Provincial Journal Article 2020 06 03 England Phytochem Anal 9200492 0958-0344 0 Drugs, Chinese Herbal IM Animals Chromatography, High Pressure Liquid Drugs, Chinese Herbal Gastrodia Metabolomics Rhizome Zebrafish Gastrodiae Rhizoma Gray correlation analysis angiogenesis network pharmacology analysis proangiogenic chemical marker zebrafish 2020 02 14 2020 04 19 2020 04 21 2020 6 5 6 0 2020 12 15 6 0 2020 6 5 6 0 ppublish 32495458 10.1002/pca.2949