Scientific:
Datura inoxia (Folia Metel)
Epinephelus fasciatus (Metel)
Synonyms:
Carcharhinus altimus (bignose shark)
Carcharhinus obscurus (Common whaler)
Carcharinus obscurus
Epinephalus fasciatus
Epinephelus fasciatus (bluetipped rockcod)
Epinephelus septemfasciatus (Bar rockcod)
Perca fasciata
Squalus obscurus
Broader Terms:
Carcharhiniformes (ground sharks)
Carcharhinus (gray sharks)
Carcharinus
Epinephalus
Epinephelus (groupers)
Perca (yellow perches)
Perciformes (perch-likes)
Squalus (Spiny dogfish)
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Datura inoxia
Jana Zichová - BioLib |
Did you mean: Metella or Metellus?
1. Daturataturin A, a withanolide in Datura metel L., induces HaCaT autophagy through the PI3K-Akt-mTOR signaling pathway.
Wei Z, Li T, Sun Y, Su H, Zeng Y, Wang Q, Kuang H
Phytotherapy research : PTR Phytother Res Daturataturin A, a withanolide in Datura metel L., induces HaCaT autophagy through the PI3K-Akt-mTOR signaling pathway. 1546-1558 10.1002/ptr.6921 Daturataturin A (DTA), a withanolide compound in Datura metel L., exhibits excellent anti-inflammatory and anti-proliferative activities. Here, we report the study of DTA-induced proliferation and inflammation in human immortalized keratinocytes (HaCaTs) and the associated molecular mechanisms. HaCaTs are a model of the epidermal proliferative state of cells. The pharmacodynamics and mechanism of DTA were studied by western blot, immunofluorescence, apoptosis and proliferation detection, and real-time quantitative polymerase chain reaction. We confirmed that DTA induced HaCaT autophagy, which, in turn, induced HaCaT senescence and, ultimately, led to cell cycle arrest. DTA also negatively regulated inflammation through the activation of autophagy. This may be one of the mechanisms underlying the action of Datura metel L. preparation used for the treatment of psoriasis. © 2021 John Wiley & Sons Ltd. Wei Zheng Z https://orcid.org/0000-0002-5103-9103 College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China. Li Tingting T College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China. Sun Yanping Y College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China. Su Huilin H College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China. Zeng Yuanning Y College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China. Wang Qiuhong Q College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China. Kuang Haixue H https://orcid.org/0000-0001-9136-8414 College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China. eng 2013CB531801 Major State Basic Research Development Program of China 2018YFC1707105 National Key R&D Program of China Journal Article 2021 02 09 England Phytother Res 8904486 0951-418X 0 Withanolides EC 2.7.11.1 Proto-Oncogene Proteins c-akt IM Cell Proliferation Datura metel chemistry Humans Phosphatidylinositol 3-Kinases metabolism Proto-Oncogene Proteins c-akt metabolism Signal Transduction Withanolides pharmacology therapeutic use autophagy daturataturin A inflammation proliferation senescence 2020 06 02 2020 03 05 2020 10 07 2021 2 10 6 0 2021 4 20 6 0 2021 2 9 12 12 ppublish 33560581 10.1002/ptr.6921 REFERENCES, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>2. <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>UPLC-orbitrap-MS-based metabolic profiling of HaCaT cells exposed to withanolides extracted from Datura <b>metel</b>.L: Insights from an untargeted metabolomics.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a>
<br><span class=j>Li T, Wei Z, Kuang H<br><font color=gray><i>Journal of pharmaceutical and biomedical analysis, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>3. <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Machine Learning-Based Identification of Suicidal Risk in Patients With Schizophrenia Using Multi-Level Resting-State fMRI Features.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a>
<br><span class=j>Bohaterewicz B, Sobczak AM, Podolak I, Wójcik B, M?tel D, Chrobak AA, Fa Frowicz M, Siwek M, Dudek D, Marek T<br><font color=gray><i>Frontiers in neuroscience, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>4. <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Implementation of virtual reality (VR) in diagnostics and therapy of nonaffective psychoses.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a>
<br><span class=j>Kruk D, M?tel D, Gaw?da ?, Cechnicki A<br><font color=gray><i>Psychiatria polska, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>5. <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>New indole alkaloids from the seeds of Datura <b>metel</b> L.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a>
<br><span class=j>Liu Y, Jiang HB, Liu Y, Algradi AM, Naseem A, Zhou YY, She X, Li-Li, Yang BY, Kuang HX<br><font color=gray><i>Fitoterapia, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>6. <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Gastrointestinal Motility, Muscle Relaxation, Antipyretic and Acute Toxicity Screening of Amyrin Type Triterpenoid (Daturaolone) Isolated From <i>Datura <b>metel</b></i> Linnaeus (Angel's Trumpet) Fruits.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a>
<br><span class=j>Bawazeer S, Rauf A, Bawazeer S<br><font color=gray><i>Frontiers in pharmacology, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>7. <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Potent <i>In Vitro ?</i>-Glucosidase and <i>?</i>-Secretase Inhibition of Amyrin-Type Triterpenoid Isolated from <i>Datura <b>metel</b></i> Linnaeus (Angel's Trumpet) Fruits.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a>
<br><span class=j>Bawazeer S, Rauf A, Bawazeer S<br><font color=gray><i>BioMed research international, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>8. <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Premorbid social relationships and the course of schizophrenia in a 20-year follow-up study.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a>
<br><span class=j>Cechnicki A, Biela?ska A, Arciszewska-Leszczuk A, Kalisz A, B??dzi?ski P, Daren A, M?tel D, Kruk D<br><font color=gray><i>Psychiatria polska, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>9. <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Nephroprotective effects of Datura <b>metel</b> extract in gentamicin induced mice model: biochemical and histological evidences.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a>
<br><span class=j>Alam W, Khan H, Khan SA, Ali N, Sharif N, Ghafar R, Daglia M, Nazir S<br><font color=gray><i>Cellular and molecular biology (Noisy-le-Grand, France), 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>10. <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Seven new glycosides from the leaves of <i>Datura <b>metel</b></i> L.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a>
<br><span class=j>Tan JY, Liu Y, Cheng YG, Sun YP, Li XM, Guan W, Pan J, Yang BY, Kuang HX<br><font color=gray><i>Natural product research, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br><br><br><table cellspacing=0 cellpadding=0 align=center><tr valign=bottom><td align=center><img src=p.png border=0></td><td align=center><img src=o_red.png border=0></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=2><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=3><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=4><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=5><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=6><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=7><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=8><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=9><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=10><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=2><img src=rtal.png border=0></a></td></tr><td align=center></td><td align=center>1</td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=2>2</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=3>3</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=4>4</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=5>5</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=6>6</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=7>7</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=8>8</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=9>9</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=10>10</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Metel&category=l&client=pubmed&startPage=2>»</a></td></tr></table></table></tr></table></td><script src="http://www.google-analytics.com/urchin.js" type="text/javascript">
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