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 1. Clinical molecular genetics evaluation in women with reproductive failures.
Bilal MY, Katara G, Dambaeva S, Kwak-Kim J, Gilman-Sachs A, Beaman KD American journal of reproductive immunology (New York, N.Y. : 1989) Am J Reprod Immunol Clinical molecular genetics evaluation in women with reproductive failures. e13313 10.1111/aji.13313 Molecular diagnostics is a rapidly growing branch of the clinical laboratory and has accelerated the advance of personalized medicine in the fields of pharmacogenomics, pharmacogenetics, and nutrigenomics. The versatility of molecular biology allows it to be effective in several medical fields that include reproduction, immunogenetics, and virology. Implementation of molecular and sequencing technology in reproductive medicine can add another layer of understanding to better define the causes behind infertility and recurrent reproductive loss. In the following, we examine current molecular methods for probing factors behind reproductive pregnancy loss including reverse transcription polymerase chain reaction and next generation sequencing (NGS). We review several current and potential genetic (DNA) and transcriptional (RNA)-based parameters in women with infertility that can be significant in diagnosis and treatment. These molecular factors can be inferred either from genomic DNA or RNA locally within the endometrium. Furthermore, we consider infection-based abnormalities such as human herpesvirus-6 and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Finally, we present future directions as well as data demonstrating the potential role of human endogenous retroviruses in pregnancy loss. We hope these discussions will assist the clinician in delineating some of the intricate molecular factors that can contribute to infertility and recurrent reproductive failures. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Bilal Mahmood Y MY https://orcid.org/0000-0002-7370-0329 Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. Katara Gajendra G Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. Dambaeva Svetlana S https://orcid.org/0000-0002-1145-1814 Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. Kwak-Kim Joanne J https://orcid.org/0000-0002-8409-1645 Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. Department of Obstetrics and Gynecology, Rosalind Franklin University Health System, Vernon Hills, IL, USA. Gilman-Sachs Alice A https://orcid.org/0000-0002-8947-1436 Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. Beaman Kenneth D KD Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. eng Journal Article 2020 07 25 Denmark Am J Reprod Immunol 8912860 1046-7408 IM COVID-19 HERV HHV-6 MTHFR NGS RNASeq endometrial analysis molecular diagnostics reproduction 2020 05 26 2020 06 24 2020 07 20 2020 7 28 6 0 2020 7 28 6 0 2020 7 26 6 0 aheadofprint 32710571 10.1111/aji.13313 REFERENCES, 2020 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0
2. Comparison of epidermal growth factor receptor mutation detection turnaround times and concordance among real-time polymerase chain reaction, high-throughput next-generation sequencing and the Biocartis Idylla? platforms in non-small cell lung carcinomas.
Sharma S, Satapathy A, Aggarwal A, Dewan A, Jain E, Katara R, Kumar V, Pal R, Pandey S, Naidu MM, Kini L, Pradhan D, Mohanty SK Pathology, research and practice, 2021 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0
3. Repurposing of FDA approved drugs and their validation against potential drug targets for Salmonella enterica through molecular dynamics simulation.
Kesharwani A, Chaurasia DK, Katara P Journal of biomolecular structure & dynamics, 2021 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0
4. Von Hippel-Lindau Disease: A Rare Radiological Case Report of a Symptomatic Patient and His Asymptomatic Genetic Counterpart.
Khanduri S, Khan N, Malik S, Katara S, Fatima M Cureus, 2021 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0
5. A general overview of mucocele of appendix.
Singh MP Journal of family medicine and primary care, 2020 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0
6. Anther Culture Efficiency in Quality Hybrid Rice: A Comparison between Hybrid Rice and Its Ratooned Plants.
Pattnaik SS, Dash B, Bhuyan SS, Katara JL, Parameswaran C, Verma R, Ramesh N, Samantaray S Plants (Basel, Switzerland), 2020 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0
7. In vivo anti-V-ATPase antibody treatment delays ovarian tumor growth by increasing antitumor immune responses.
Kulshrestha A, Katara GK, Ibrahim SA, Riehl VE, Schneiderman S, Bilal M, Young AN, Levine S, Fleetwood S, Dolan J, Gilman-Sachs A, Beaman KD Molecular oncology, 2020 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0
8. Genome Editing in Cereals: Approaches, Applications and Challenges.
Ansari WA, Chandanshive SU, Bhatt V, Nadaf AB, Vats S, Katara JL, Sonah H, Deshmukh R International journal of molecular sciences, 2020 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0
9. Molecular detection of Mycobacterium leprae using RLEP-PCR in post elimination era of leprosy.
Mohanty PS, Naaz F, Bansal AK, Kumar D, Sharma S, Arora M, Singh H, Katara P, Soni N, Patil SA, Singh M Molecular biology research communications, 2020 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0
10. Differential Expression of Genes at Panicle Initiation and Grain Filling Stages Implied in Heterosis of Rice Hybrids.
Katara JL, Verma RL, Parida M, Ngangkham U, Molla KA, Barbadikar KM, Mukherjee M, C P, Samantaray S, Ravi NR, Singh ON, Mohapatra T International journal of molecular sciences, 2020 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0
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