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71.  Photoadaptation to ultraviolet B TL01 in psoriatic patients.LinkIT
Pacifico A, Damiani G, Iacovelli P, Conic RRZ, Scarabello A, Filoni A, Malagoli P, Bragazzi NL, Pigatto PDM, Morrone A
Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Photoadaptation to ultraviolet B TL01 in psoriatic patients. 1750-1754 10.1111/jdv.16209 In the biologic era, narrow-band ultraviolet B (NB-UVB) phototherapy still remains a valuable, effective, inexpensive, safe anti-psoriatic treatment. Patients can lose response to NB-UVB over time due to photoadaptation. This phenomenon is the tendency of the skin to respond to ultraviolet (UV) exposure by undergoing changes that may result in a decreased future response to an equivalent dose of radiation, thus leading to the need for an increased exposure during phototherapy course. To characterize and quantify the determinants of photoadaptation in NB-UVB treated psoriatic patients. We enrolled 57 adult patients with moderate plaque psoriasis. Patients underwent 24 sessions of NB-UVB phototherapy delivered thrice a week. Dosing was started with 70% of the minimal erythema dose (MED) with percentage-based dose increments every two treatments. MED as well as change in the erythema and melanin index (MI) were measured at baseline and at the end of phototherapy course. Moreover, an adaptation factor (AF) was calculated for each patient. Adaptation factor was not influenced by both baseline MED and skin type. We found a weak correlation between higher cumulative dosages and the initial MED (Spearman's rho¬†=¬†0.32, P¬†=¬†0.0154) as well as with the mean initial MI (Spearman's rho¬†=¬†0.25, P¬†=¬†0.0624, statistically borderline). Clearance and mean number of treatments were correlated (Spearman's rho¬†=¬†0.48, P¬†<¬†0.001). Photoadaptation is a physiological skin response that negatively influences NB-UVB responsiveness and is not predictable by the baseline MED and skin type. Thus, starting with more aggressive protocols and increasing rapidly dosage progression to prevent AF may increase NB-UVB response. ¬© 2020 European Academy of Dermatology and Venereology. Pacifico A A https://orcid.org/0000-0003-0348-0620 San Gallicano Dermatological Institute, IRCCS, Rome, Italy. Damiani G G Clinical Dermatology, IRCCS IstitutoOrtopedico Galeazzi, Milan, Italy. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy. Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA. Young Dermatologists Italian Network (YDIN), GISED, Bergamo, Italy. Iacovelli P P San Gallicano Dermatological Institute, IRCCS, Rome, Italy. Conic R R Z RRZ https://orcid.org/0000-0002-9209-2883 Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA. Scarabello A A San Gallicano Dermatological Institute, IRCCS, Rome, Italy. Filoni A A San Gallicano Dermatological Institute, IRCCS, Rome, Italy. Malagoli P P Dermatology Unit, Azienda Ospedaliera San Donato Milanese, Milan, Italy. Bragazzi N L NL School of Public Health, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy. Pigatto P D M PDM Clinical Dermatology, IRCCS IstitutoOrtopedico Galeazzi, Milan, Italy. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy. Morrone A A San Gallicano Dermatological Institute, IRCCS, Rome, Italy. eng Journal Article 2020 04 27 England J Eur Acad Dermatol Venereol 9216037 0926-9959 IM 2019 05 31 2019 11 27 2020 1 23 6 0 2020 1 23 6 0 2020 1 23 6 0 ppublish 31967696 10.1111/jdv.16209 References, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>72.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Artificial neural networks allow response prediction in squamous cell carcinoma of the scalp treated with radiotherapy.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Damiani G, Grossi E, Berti E, Conic RRZ, Radhakrishna U, Pacifico A, Bragazzi NL, Piccinno R, Linder D<br><font color=gray><i>Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Artificial neural networks allow response prediction in squamous cell carcinoma of the scalp treated with radiotherapy. 1369-1373 10.1111/jdv.16210 Epithelial neoplasms of the scalp account for approximately 2% of all skin cancers and for about 10-20% of the tumours affecting the head and neck area. Radiotherapy is suggested for localized cutaneous squamous cell carcinomas (cSCC) without lymph node involvement, multiple or extensive lesions, for patients refusing surgery, for patients with a poor general medical status, as adjuvant for incompletely excised lesions and/or as a palliative treatment. To date, prognostic risk factors in scalp cSCC patients are poorly characterized. To identify patterns of patients with higher risk of postradiotherapy recurrence. A retrospective observational study was performed on scalp cSCC patients with histological diagnosis who underwent conventional radiotherapy (50-120¬†kV) (between 1996 and 2008, follow-up from 1 to 140 months, median 14¬†months). Out of the 79 enrolled patients, 22 (27.8%) had previously undergone a surgery. Two months after radiotherapy, 66 (83.5%) patients achieved a complete remission, 6 (7.6%) a partial remission, whereas 2 (2.5%) proved non-responsive to the treatment and 5 cases were lost to follow-up. Demographical and clinical data were preliminarily analysed with classical descriptive statistics and with principal component analysis. All data were then re-evaluated with a machine learning-based approach using a 4th generation artificial neural networks (ANNs)-based algorithm. Artificial neural networks analysis revealed four scalp cSCC profiles among radiotherapy responsive patients, not previously described: namely, (i) stage T2 cSCC type, aged 70-80¬†years; (ii) frontal cSCC type, aged <70¬†years; (iii) non-recurrent nodular or nodulo-ulcerated, stage T3 cSCC type, of the vertex and treated with >60 Grays (Gy); and (iv) flat, occipital, stage T1 cSCC type, treated with 50-59¬†Gy. The model uncovering these four predictive profiles displayed 85.7% sensitivity, 97.6% specificity and 91.7% overall accuracy. Patient profiling/phenotyping with machine learning may be a new, helpful method to stratify patients with scalp cSCCs who may benefit from a RT-treatment. ¬© 2020 European Academy of Dermatology and Venereology. Damiani G G https://orcid.org/0000-0002-2390-6505 Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy. Young Dermatologists Italian Network, Centro Studi GISED, Bergamo, Italy. Grossi E E Fondazione Villa Santa Maria, Tavernerio, Como, Italy. Berti E E Phototherapy Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy. Dermatology Unit, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Universit√† degli Studi di Milano, Milan, Italy. Conic R R Z RRZ https://orcid.org/0000-0002-9209-2883 Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA. Radhakrishna U U Department of Obstetrics and Gynecology, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA. Pacifico A A https://orcid.org/0000-0003-0348-0620 Clinical Dermatology Department, IRCCS S. Gallicano Dermatological Institute, Rome, Italy. Bragazzi N L NL School of Public Health, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy. Piccinno R R Phototherapy Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy. Dermatology Unit, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Universit√† degli Studi di Milano, Milan, Italy. Linder D D https://orcid.org/0000-0002-0305-3146 Ben Gurion University of the Negev, Beer Sheva, Israel. eng Journal Article 2020 03 04 England J Eur Acad Dermatol Venereol 9216037 0926-9959 IM 2019 10 14 2020 01 07 2020 1 23 6 0 2020 1 23 6 0 2020 1 23 6 0 ppublish 31968143 10.1111/jdv.16210 References, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>73.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>The International Classification of Functioning, Disability and Health-Children and Youth as a framework for the management of spinal muscular atrophy in the era of gene therapy: a proof-of-concept study.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Trabacca A, Lucarelli E, Pacifico R, Vespino T, Di Liddo A, Losito L<br><font color=gray><i>European journal of physical and rehabilitation medicine, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>74.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Dual use of bronchodilators versus monotherapy, and its impact on pulmonary rehabilitation in COPD patients.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Benavides-Cordoba V, Aviles S, Ascuntar C, Orozco L, Mosquera R, Rivera J<br><font color=gray><i>Pulmonary pharmacology & therapeutics, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>75.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Impact of DOM source and character on the degradation of primidone by UV/chlorine: Reaction kinetics and disinfection by-product formation.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Wang Y, Couet M, Gutierrez L, Allard S, Crou√© JP<br><font color=gray><i>Water research, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>76.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>ASSOCIATION BETWEEN PHYSICAL ACTIVITY PRACTICE AND CLUSTERING OF HEALTH RISK BEHAVIORS IN ADOLESCENTS.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Silva MPD, Pac√≠fico AB, Piola TS, Fantinelli ER, Camargo EM, Legnani RFS, Campos W<br><font color=gray><i>Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>77.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Lower Pole Mastopexy-Augmentation: Indications and Applications.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Pacifico MD<br><font color=gray><i>Aesthetic surgery journal, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>78.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>New SiO<sub>2</sub>/Caffeic Acid Hybrid Materials: Synthesis, Spectroscopic Characterization, and Bioactivity.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Catauro M, Barrino F, Dal Poggetto G, Crescente G, Piccolella S, Pacifico S<br><font color=gray><i>Materials (Basel, Switzerland), 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>79.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Neuron-based high-content assay and screen for CNS active mitotherapeutics.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Varkuti BH, Kepiro M, Liu Z, Vick K, Avchalumov Y, Pacifico R, MacMullen CM, Kamenecka TM, Puthanveettil SV, Davis RL<br><font color=gray><i>Science advances, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>80.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Pattern formation induced by intraspecific interactions in a predator-prey system.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Stucchi L, Galeano J, Vasquez DA<br><font color=gray><i>Physical review. E, 2019</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br><br><br><table cellspacing=0 cellpadding=0 align=center><tr valign=bottom><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=7><img src=p.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=1><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=2><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=3><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=4><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=5><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=6><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=7><img src=o_yellow.png border=0></a></td><td align=center><img src=o_red.png border=0></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=9><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=10><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=11><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=12><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=13><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=14><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=15><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=16><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=17><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=9><img src=rtal.png border=0></a></td></tr><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=7>¬ę</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=1>1</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=2>2</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=3>3</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=4>4</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=5>5</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=6>6</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=7>7</a></td><td align=center>8</td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=9>9</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=10>10</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=11>11</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=12>12</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=13>13</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=14>14</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=15>15</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=16>16</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=17>17</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Guaseta+pac%C3%ADfico&category=l&client=pubmed&startPage=9>¬Ľ</a></td></tr></table></table></tr></table></td><script 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