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Synonyms:
   Bacillus/Clostridium 
   Clostridium firmicutes 
   Firmacutes 
   Firmicutes 
   Low firmicutes 
   clostridial firmicutes 

Broader Terms:
   Bacteria 
   Bacteria regnum 
   Eubacteria 
   Gram-positive 

More Specific:
   Bacilli 
   Clostridia 
   Gram positive walls 
   Mollicutes 
   environmental samples 
   unclassified 
 
 


External Resources:



1.  Engineering a lysin with intrinsic antibacterial activity (LysMK34) with cecropin A enhances its antibacterial properties against Acinetobacter baumannii.LinkIT
Abdelkader K, Gutiérrez D, Tamés-Caunedo H, Ruas-Madiedo P, Safaan A, Khairalla AS, Gaber Y, Dishisha T, Briers Y
Applied and environmental microbiology, 2021
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

2.  Streptomyces coelicolor vesicles: many molecules to be delivered.LinkIT
Faddetta T, Renzone G, Vassallo A, Rimini E, Nasillo G, Buscarino G, Agnello S, Licciardi M, Botta L, Scaloni A, Palumbo Piccionello A, Puglia AM, Gallo G
Applied and environmental microbiology, 2021
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

3.  Discovery and structure-activity relationships of the quinolinequinones: Promising antimicrobial agents and mode of action evaluation.LinkIT
Matarac?-Kara E, Bayrak N, Y?ld?z M, Y?ld?r?m H, Özbek-Çelik B, Tuyun AF
Drug development researchDrug Dev ResDiscovery and structure-activity relationships of the quinolinequinones: Promising antimicrobial agents and mode of action evaluation.10.1002/ddr.21893In our pursuit of developing the novel, potent, and selective antimicrobial agents, we managed to obtain the quinolinequinone for their antimicrobial profile with minimal inhibitory concentrations (MICs) determined against a panel of seven bacterial strains (three gram-positive and four gram-negative bacteria) and three fungi. The structure-activity relationship (SAR) for the quinolinequinone class of antimicrobials was determined. Interestingly, QQ1, QQ4, QQ6-9, QQ12, and QQ13 displayed equal antibacterial potential against S. aureus (MIC = 1.22?mg/L), respectively, to the standard positive control Cefuroxime-Na. QQ10 had the best inhibitory activity with the MIC value of 1.22?mg/L (fourfold more potent compared to reference standard Clotrimazole) against Candida albicans. On the other hand, while QQ10 is not too effective against gram-positive bacteria as much as the other analogs, QQ10 was the most effective quinolinequinones against fungi. Selected quinolinequinones were further evaluated for the mode of action, using in vitro antibiofilm activity, bactericidal activity by using time-kill curve assay, antibiofilm activity, and potential antimicrobial activity against each of 32 clinically obtained resistant strains of Gram-positive Bacteria. The results also revealed that the QQ14 had specific antifungal activity against fungi in particular C. albicans. Our results clearly showed that quinolinequinones are much more active in the inhibition of the biofilm attachment process than the inhibition of mature biofilm formation. Thus, as treatment options are narrowing for Methicillin-resistant Staphylococcus spp., Vancomycin-resistant Staphylococcus spp. daily, the quinolinequinones reported herein display promise as the lead candidates for further clinical applications against serious infections.© 2021 Wiley Periodicals LLC.Matarac?-KaraEmelEhttps://orcid.org/0000-0003-4541-1893Pharmaceutical Microbiology Department, Pharmacy Faculty, Istanbul University, Istanbul, Turkey.BayrakNilüferNhttps://orcid.org/0000-0002-0777-4012Department of Chemistry, Faculty of Engineering, Istanbul University, Istanbul, Turkey.Y?ld?zMahmutMhttps://orcid.org/0000-0001-6317-5738Chemistry Department, Gebze Technical University, Kocaeli, Turkey.Y?ld?r?mHaticeHhttps://orcid.org/0000-0003-3988-6120Department of Chemistry, Faculty of Engineering, Istanbul University, Istanbul, Turkey.Özbek-ÇelikBernaBhttps://orcid.org/0000-0001-8909-8398Pharmaceutical Microbiology Department, Pharmacy Faculty, Istanbul University, Istanbul, Turkey.TuyunAmaç FatihAFhttps://orcid.org/0000-0001-5698-1109Department of Chemistry, Faculty of Science, Istanbul University, Istanbul, Turkey.eng118Z620Türkiye Bilimsel ve Teknolojik Ara?tirma KurumuJournal Article20211020United StatesDrug Dev Res82044680272-4391IMantibacterial activityantibiofilm activityantifungal activitybactericidal effectkinetic studyquinolinequinones2021091120210717202110042021102085120211021602021102160aheadofprint3466859310.1002/ddr.21893REFERENCES, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>4.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Emissive oxidase-like nanozyme based on an organic molecular cage.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Wang Z, Yang BB, Fang ZJ, Ou Q, Ma H, Zhang QP, Sun YL, Zhang C<br><font color=gray><i>Chemical communications (Cambridge, England), 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>5.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>PANI-Fe<sub>3</sub>O<sub>4</sub>@ZnO nanocomposite as magnetically recoverable organometallic nanocatalyst promoted synthesis of new Azo chromene dyes and evaluation of their antioxidant and antimicrobial activities.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Abdolmohammadi S, Hossaini Z, Poor Heravi MR<br><font color=gray><i>Molecular diversity, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>6.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Novel ocotillol-derived lactone derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Zhang Z, Zeng X, Zhang S, Zhou Y, Zhou Z<br><font color=gray><i>Molecular diversity, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>7.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Characterization of an emergent high-risk KPC-producing Klebsiella pneumoniae lineage causing a fatal wound infection after spine surgery.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Boff L, de Sousa Duarte H, Kraychete GB, de Castro Santos MG, Vommaro RC, Lima COGX, Lima-Morales D, Wink PL, de Oliveira Ferreira E, Picão RC, da Rocha VM<br><font color=gray><i>Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>8.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Biochemical Investigation of an N-acetyltransferase from Helicobacter pullorum.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Griffiths WA, Spencer KD, Thoden JB, Holden HM<br><font color=gray><i>Protein science : a publication of the Protein Society, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>9.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Bloodstream Infections and Outcomes Following Allogeneic Hematopoietic Cell Transplantation: a Single-Center Study.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Carreira AS, Salas MQ, Remberger M, Basso IN, Law AD, Lam W, Pasic I, Kim D, Michelis FV, Viswabandya A, Gerbitz A, Lipton JH, Husain S, Kumar R, Mattsson J<br><font color=gray><i>Transplantation and cellular therapy, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>10.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Cerebrospinal Fluid Shunt Infections in Children: Do Hematologic and Cerebrospinal Fluid White Cells Examinations Correlate With the Type of Infection?</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Buonsenso D, Bianchi F, Scoppettuolo G, Frassanito P, Massimi L, Caldarelli M, Salvatelli N, Ferro V, Valentini P, Tamburrini G<br><font color=gray><i>The Pediatric infectious disease journal, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br><br><br><table cellspacing=0 cellpadding=0 align=center><tr valign=bottom><td align=center><img src=p.png border=0></td><td align=center><img src=o_red.png border=0></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=2><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=3><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=4><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=5><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=6><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=7><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=8><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=9><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=10><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=2><img src=rtal.png border=0></a></td></tr><td align=center></td><td align=center>1</td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=2>2</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=3>3</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=4>4</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=5>5</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=6>6</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=7>7</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=8>8</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=9>9</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=10>10</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Gram-positive+bacteria&category=l&client=pubmed&startPage=2>»</a></td></tr></table></table></tr></table></td><script 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