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Synonyms:
   Elapidae (Elapids) 

Broader Terms:
   Alethinophidia 
   Colubroidea 
   Elapidae (coral snakes) 
   Serpentes (snakes) 
   Squamata (amphisbaenians) 
   Xenophidia 

More Specific:
   Acalyptophis (Perron's Sea Snake) 
   Acanthophiinae 
   Acanthophis (Death Adders) 
   Adeniophis 
   Aeluroscalabotes (Cat Geckos) 
   Afroedura (Rock Geckos) 
   Afrogecko 
   Agamura (Spider Geckos) 
   Ailuronyx (Dumeril's Geckos) 
   Aipysurus (Sea Snake) 
   Alsophylax (Even-Fingered Geckos) 
   Aristelliger (croaking geckos) 
   Asaccus (Middle Eastern Geckos) 
   Aspidelaps (Shieldnose Cobras) 
   Aspidoclonion 
   Aspidomorphus (Collared Adders) 
   Aspis 
   Astrotia (Stokes' Sea Snake) 
   Atractaspis (Mole Viper) 
   Austrelaps (Australian Copperheads) 
   Bioliophis 
   Blaesodactylus 
   Boa (Boa Constrictors) 
   Bogertia (Bogert's Geckos) 
   Boulengerina (Water Cobras) 
   Briba (Brazilian Gecko) 
   Bungarinae 
   Bungarus (Indian Kraits) 
   Bunopus (Arabian Rock Geckos) 
   Cacophis (Dwarf Crowned Snake) 
   Calliophis (Oriental Coral Snake) 
   Callophis 
   Calodactylodes (Indian Geckos) 
   Carinatogecko (Strand's Geckos) 
   Carphodactylus (Chameleon Geckos) 
   Cerastes (Horned Vipers) 
   Chondrodactylus (Whorled Sand Gekos) 
   Christinus (Australian Clawed Geckos) 
   Cnemaspis (Small-Toed Geckos) 
   Coleodactylus (Amazon Geckos) 
   Coleonyx (banded geckos) 
   Colopus (Kalahari Geckos) 
   Coluber (racer) 
   Cosymbotus (Asian House Geckos) 
   Crenadactylus (Clawless Geckos) 
   Crossobamon (Comwtoed Geckos) 
   Cryptactites 
   Crytophis 
   Cyrtodactylus (curve-toed geckos) 
   Cyrtophis 
   Cyrtopodion (bow-footed geckos) 
   Demansia (Venomous Whip Snake) 
   Dendraphis 
   Dendraspis 
   Dendroaspis (Mambas) 
   Dendrospis 
   Denisonia (Ornamental Snake) 
   Dinophis 
   Diplodactylus (Spinytail Geckos) 
   Dixonius 
   Doliophis 
   Drysdalia (Ausrtalian Crowned Snake) 
   Ebenavia (Madagascar Clawless Geckos) 
   Echiopsis (Bardick Snake) 
   Elapechis 
   Elapinae 
   Elapognathus (Little Brown Snake) 
   Elaps 
   Elapsoidea (Venomous Garter Snake) 
   Emydocephalus (Turtlehead Sea Snake) 
   Enhydrina (Beaked Sea Snake) 
   Ephalophis (Grey's Sea Snake) 
   Eublepharis (Eyelid Geckos) 
   Euleptes 
   Eurydactylodes (Prehensiletail Geckos) 
... 
 
Latest Articles on Elapidae from uBioRSS


Cerastes cerastes
Ivan Mik?k - BioLib

External Resources:

Common Names: Coralsnakes, コブラ科, coral snakes, Cobras, Elapids, Kraits



1.  Genome-wide SNPs clarify lineage diversity confused by coloration in coralsnakes of the Micrurus diastema species complex (Serpentes: Elapidae).LinkIT
Reyes-Velasco J, Adams RH, Boissinot S, Parkinson CL, Campbell JA, Castoe TA, Smith EN
Molecular phylogenetics and evolution, 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

2.  Snake C-Type Lectins Potentially Contribute to the Prey Immobilization in Protobothrops mucrosquamatus and Trimeresurus stejnegeri Venoms.LinkIT
Tian H, Liu M, Li J, Xu R, Long C, Li H, Mwangi J, Lu Q, Lai R, Shen C
Toxins, 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

3.  Coral snake bites in Brazilian Amazonia: Perpetrating species, epidemiology and clinical aspects.LinkIT
Bisneto PF, Alcântara JA, Mendonça da Silva I, de Almeida Gonçalves Sachett J, Bernarde PS, Monteiro WM, Kaefer IL
Toxicon : official journal of the International Society on Toxinology, 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

4.  Effects of Mlx-8, a phospholipase A2 from Brazilian coralsnake Micrurus lemniscatus venom, on muscarinic acetylcholine receptors in rat hippocampus. e20190041 10.1590/1678-9199-JVATITD-2019-0041 Here, we described the presence of a neurotoxin with phospholipase A2 activity isolated from Micrurus lemniscatus venom (Mlx-8) with affinity for muscarinic acetylcholine receptors (mAChRs). The purification, molecular mass determination, partial amino acid sequencing, phospholipase A2 activity determination, inhibition of the binding of the selective muscarinic ligand [3H]QNB and inhibition of the total [3H]inositol phosphate accumulation in rat hippocampus of the Mlx-8 were determined. Thirty-one fractions were collected from HPLC chromatography, and the Mlx-8 toxin was used in this work. The molecular mass of Mlx-8 is 13.628 Da. Edman degradation yielded the following sequence: NLYQFKNMIQCTNTRSWL-DFADYG-CYCGRGGSGT. The Mlx-8 had phospholipase A2 enzymatic activity. The pKi values were determined for Mlx-8 toxin and the M1 selective muscarinic antagonist pirenzepine in hippocampus membranes via [3H]QNB competition binding assays. The pKi values obtained from the analysis of Mlx-8 and pirenzepine displacement curves were 7.32 ± 0.15, n = 4 and 5.84 ± 0.18, n = 4, respectively. These results indicate that Mlx-8 has affinity for mAChRs. There was no effect on the inhibition ability of the [3H]QNB binding in hippocampus membranes when 1 µM Mlx-8 was incubated with 200 µM DEDA, an inhibitor of phospholipase A2. This suggests that the inhibition of the phospholipase A2 activity of the venom did not alter its ability to bind to displace [3H]QNB binding. In addition, the Mlx-8 toxin caused a blockade of 43.31 ± 8.86%, n = 3 and 97.42 ± 2.02%, n = 3 for 0.1 and 1 µM Mlx-8, respectively, on the total [3H]inositol phosphate content induced by 10 µM carbachol. This suggests that Mlx-8 inhibits the intracellular signaling pathway linked to activation of mAChRs in hippocampus. The results of the present work show, for the first time, that muscarinic receptors are also affected by the Mlx-8 toxin, a muscarinic ligand with phospholipase A2 characteristics, obtained from the venom of the Elapidae snake Micrurus lemniscatus, since this toxin was able to compete with muscarinic ligand [3H]QNB in hippocampus of rats. In addition, Mlx-8 also blocked the accumulation of total [3H]inositol phosphate induced by muscarinic agonist carbachol. Thus, Mlx-8 may be a new pharmacological tool for examining muscarinic cholinergic function. Dos Santos Roberta Tancredi Francesco RTF Laboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil. Silva Marcelo Florencio Passos MFP Laboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil. Porto Rafael Marques RM Laboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, SP, Brazil. Lebrun Ivo I Laboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, SP, Brazil. Gonçalves Luís Roberto de Camargo LRC Laboratory of Pathophysiology, Butantan Institute, São Paulo, SP, Brazil. Batista Isabel de Fátima Correia IFC Laboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, SP, Brazil. Sandoval Maria Regina Lopes MRL Laboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil. Abdalla Fernando Maurício Francis FMF 0000-0003-2276-6202 Laboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil. eng Journal Article 2020 01 27 Brazil J Venom Anim Toxins Incl Trop Dis 101201501 1678-9180 Hippocampus Inositol phosphate Micrurus lemniscatus Muscarinic receptors Phopholipase A2 Competing interests: The authors declare that they have no competing interests. 2019 07 05 2019 12 04 2020 2 18 6 0 2020 2 18 6 0 2020 2 18 6 1 epublish 32063920 10.1590/1678-9199-JVATITD-2019-0041 PMC6986814 Neuron. 2016 Sep 21;91(6):1199-1218 27657448 Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:71-82 12432910 Pharmacol Biochem Behav. 2003 Jan;74(2):411-5 12479962 Toxicon. 2003 Feb;41(2):207-15 12565740 Mol Cell Endocrinol. 2000 Feb 25;160(1-2):17-24 10715535 Arch Toxicol. 2019 Jul;93(7):2065-2086 31123802 J Biol Chem. 2015 Sep 25;290(39):23616-30 26242733 Mol Phylogenet Evol. 2016 Jan;94(Pt B):537-547 26475614 Brain Res Bull. 2008 Mar 28;75(5):629-39 18355639 Acta Physiol (Oxf). 2012 Feb;204(2):186-201 21481193 J Proteomics. 2011 Dec 21;75(2):655-67 21963438 J Biol Chem. 1989 Jul 5;264(19):11503-10 2544597 Toxicol Lett. 2016 Aug 22;257:60-71 27282409 Pharmacol Rev. 1998 Jun;50(2):279-90 9647869 Crit Rev Neurobiol. 1996;10(1):69-99 8853955 Br J Pharmacol. 2000 Oct;131(3):447-52 11015294 J Neurochem. 2017 Aug;142 Suppl 2:7-18 28326549 J Proteomics. 2014 Jun 13;105:295-306 24613619 Clin Toxicol (Phila). 2016 Mar;54(3):222-34 26808120 Toxicon. 2008 May;51(6):1008-16 18281071 Arch Biochem Biophys. 1996 Apr 1;328(1):17-25 8638927 Eur J Pharmacol. 1985 Oct 8;116(1-2):145-52 2865157 Neuroendocrinology. 2004;80(6):379-86 15741743 Biochem Pharmacol. 2008 May 1;75(9):1827-34 18329631 Toxins (Basel). 2017 Jun 08;9(6): 28594382 PLoS One. 2017 Oct 12;12(10):e0186206 29023569 Toxicon. 2016 Nov;122:7-25 27641749 J Biol Chem. 1981 Dec 25;256(24):13172-9 6273417 Toxicon. 2011 Jul;58(1):35-45 21596052 Toxins (Basel). 2017 Mar 16;9(3): 28300784 J Neurochem. 2009 Jun;109(5):1193-202 19457160 Life Sci. 2011 Dec 19;89(25-26):931-8 22005021 Am J Physiol. 1998 Nov;275(5):H1782-7 9815086 Behav Brain Res. 2007 Feb 27;177(2):227-31 17182118 Arch Biochem Biophys. 1999 Sep 1;369(1):114-8 10462446 J Proteomics. 2019 May 30;200:90-101 30946991 Toxicon. 1995 Dec;33(12):1633-43 8866620 Eur J Pharmacol. 2004 Mar 8;487(1-3):65-72 15033377 PLoS Negl Trop Dis. 2010 Mar 09;4(3):e622 20231886 PLoS One. 2014 Dec 18;9(12):e115428 25522251 Brain Res. 2014 Mar 13;1552:1-16 24480475 Auton Autacoid Pharmacol. 2006 Jul;26(3):219-33 16879488 Pharmacol Ther. 1993 Jun;58(3):319-79 7504306 Neuropharmacology. 2018 Jul 1;136(Pt C):362-373 29138080 J Proteomics. 2011 Aug 24;74(9):1810-25 21803179 J Biol Chem. 1989 Apr 25;264(12):6674-81 2785108 Biochem Pharmacol. 1973 Dec 1;22(23):3099-108 4202581 Toxicon. 1996 Oct;34(10):1149-55 8931255 Toxicon. 2011 Nov;58(6-7):455-63 21906611 Prostaglandins. 1984 Apr;27(4):553-62 6427852 Toxins (Basel). 2017 Dec 19;9(12): 29311537 J Biol Chem. 1987 Oct 25;262(30):14402-7 3117784 31985944 NBK553151 StatPearls Publishing Treasure Island (FL) StatPearls 2020 01 2020 01 Internet Evaluation and Treatment of Snake EnvenomationsLinkIT
Dos Santos RTF, Silva MFP, Porto RM, Lebrun I, Gonçalves LRC, Batista IFC, Sandoval MRL, Abdalla FMF, , Tednes M, Slesinger TL
The journal of venomous animals and toxins including tropical diseases, 2020 The journal of venomous animals and toxins including tropical diseases J Venom Anim Toxins Incl Trop Dis Effects of Mlx-8, a phospholipase A2 from Brazilian coralsnake Micrurus lemniscatus venom, on muscarinic acetylcholine receptors in rat hippocampus. e20190041 10.1590/1678-9199-JVATITD-2019-0041 Here, we described the presence of a neurotoxin with phospholipase A2 activity isolated from Micrurus lemniscatus venom (Mlx-8) with affinity for muscarinic acetylcholine receptors (mAChRs). The purification, molecular mass determination, partial amino acid sequencing, phospholipase A2 activity determination, inhibition of the binding of the selective muscarinic ligand [3H]QNB and inhibition of the total [3H]inositol phosphate accumulation in rat hippocampus of the Mlx-8 were determined. Thirty-one fractions were collected from HPLC chromatography, and the Mlx-8 toxin was used in this work. The molecular mass of Mlx-8 is 13.628 Da. Edman degradation yielded the following sequence: NLYQFKNMIQCTNTRSWL-DFADYG-CYCGRGGSGT. The Mlx-8 had phospholipase A2 enzymatic activity. The pKi values were determined for Mlx-8 toxin and the M1 selective muscarinic antagonist pirenzepine in hippocampus membranes via [3H]QNB competition binding assays. The pKi values obtained from the analysis of Mlx-8 and pirenzepine displacement curves were 7.32 ± 0.15, n = 4 and 5.84 ± 0.18, n = 4, respectively. These results indicate that Mlx-8 has affinity for mAChRs. There was no effect on the inhibition ability of the [3H]QNB binding in hippocampus membranes when 1 µM Mlx-8 was incubated with 200 µM DEDA, an inhibitor of phospholipase A2. This suggests that the inhibition of the phospholipase A2 activity of the venom did not alter its ability to bind to displace [3H]QNB binding. In addition, the Mlx-8 toxin caused a blockade of 43.31 ± 8.86%, n = 3 and 97.42 ± 2.02%, n = 3 for 0.1 and 1 µM Mlx-8, respectively, on the total [3H]inositol phosphate content induced by 10 µM carbachol. This suggests that Mlx-8 inhibits the intracellular signaling pathway linked to activation of mAChRs in hippocampus. The results of the present work show, for the first time, that muscarinic receptors are also affected by the Mlx-8 toxin, a muscarinic ligand with phospholipase A2 characteristics, obtained from the venom of the Elapidae snake Micrurus lemniscatus, since this toxin was able to compete with muscarinic ligand [3H]QNB in hippocampus of rats. In addition, Mlx-8 also blocked the accumulation of total [3H]inositol phosphate induced by muscarinic agonist carbachol. Thus, Mlx-8 may be a new pharmacological tool for examining muscarinic cholinergic function. Dos Santos Roberta Tancredi Francesco RTF Laboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil. Silva Marcelo Florencio Passos MFP Laboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil. Porto Rafael Marques RM Laboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, SP, Brazil. Lebrun Ivo I Laboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, SP, Brazil. Gonçalves Luís Roberto de Camargo LRC Laboratory of Pathophysiology, Butantan Institute, São Paulo, SP, Brazil. Batista Isabel de Fátima Correia IFC Laboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, SP, Brazil. Sandoval Maria Regina Lopes MRL Laboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil. Abdalla Fernando Maurício Francis FMF 0000-0003-2276-6202 Laboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil. eng Journal Article 2020 01 27 Brazil J Venom Anim Toxins Incl Trop Dis 101201501 1678-9180 Hippocampus Inositol phosphate Micrurus lemniscatus Muscarinic receptors Phopholipase A2 Competing interests: The authors declare that they have no competing interests. 2019 07 05 2019 12 04 2020 2 18 6 0 2020 2 18 6 0 2020 2 18 6 1 epublish 32063920 10.1590/1678-9199-JVATITD-2019-0041 PMC6986814 Neuron. 2016 Sep 21;91(6):1199-1218 27657448 Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:71-82 12432910 Pharmacol Biochem Behav. 2003 Jan;74(2):411-5 12479962 Toxicon. 2003 Feb;41(2):207-15 12565740 Mol Cell Endocrinol. 2000 Feb 25;160(1-2):17-24 10715535 Arch Toxicol. 2019 Jul;93(7):2065-2086 31123802 J Biol Chem. 2015 Sep 25;290(39):23616-30 26242733 Mol Phylogenet Evol. 2016 Jan;94(Pt B):537-547 26475614 Brain Res Bull. 2008 Mar 28;75(5):629-39 18355639 Acta Physiol (Oxf). 2012 Feb;204(2):186-201 21481193 J Proteomics. 2011 Dec 21;75(2):655-67 21963438 J Biol Chem. 1989 Jul 5;264(19):11503-10 2544597 Toxicol Lett. 2016 Aug 22;257:60-71 27282409 Pharmacol Rev. 1998 Jun;50(2):279-90 9647869 Crit Rev Neurobiol. 1996;10(1):69-99 8853955 Br J Pharmacol. 2000 Oct;131(3):447-52 11015294 J Neurochem. 2017 Aug;142 Suppl 2:7-18 28326549 J Proteomics. 2014 Jun 13;105:295-306 24613619 Clin Toxicol (Phila). 2016 Mar;54(3):222-34 26808120 Toxicon. 2008 May;51(6):1008-16 18281071 Arch Biochem Biophys. 1996 Apr 1;328(1):17-25 8638927 Eur J Pharmacol. 1985 Oct 8;116(1-2):145-52 2865157 Neuroendocrinology. 2004;80(6):379-86 15741743 Biochem Pharmacol. 2008 May 1;75(9):1827-34 18329631 Toxins (Basel). 2017 Jun 08;9(6): 28594382 PLoS One. 2017 Oct 12;12(10):e0186206 29023569 Toxicon. 2016 Nov;122:7-25 27641749 J Biol Chem. 1981 Dec 25;256(24):13172-9 6273417 Toxicon. 2011 Jul;58(1):35-45 21596052 Toxins (Basel). 2017 Mar 16;9(3): 28300784 J Neurochem. 2009 Jun;109(5):1193-202 19457160 Life Sci. 2011 Dec 19;89(25-26):931-8 22005021 Am J Physiol. 1998 Nov;275(5):H1782-7 9815086 Behav Brain Res. 2007 Feb 27;177(2):227-31 17182118 Arch Biochem Biophys. 1999 Sep 1;369(1):114-8 10462446 J Proteomics. 2019 May 30;200:90-101 30946991 Toxicon. 1995 Dec;33(12):1633-43 8866620 Eur J Pharmacol. 2004 Mar 8;487(1-3):65-72 15033377 PLoS Negl Trop Dis. 2010 Mar 09;4(3):e622 20231886 PLoS One. 2014 Dec 18;9(12):e115428 25522251 Brain Res. 2014 Mar 13;1552:1-16 24480475 Auton Autacoid Pharmacol. 2006 Jul;26(3):219-33 16879488 Pharmacol Ther. 1993 Jun;58(3):319-79 7504306 Neuropharmacology. 2018 Jul 1;136(Pt C):362-373 29138080 J Proteomics. 2011 Aug 24;74(9):1810-25 21803179 J Biol Chem. 1989 Apr 25;264(12):6674-81 2785108 Biochem Pharmacol. 1973 Dec 1;22(23):3099-108 4202581 Toxicon. 1996 Oct;34(10):1149-55 8931255 Toxicon. 2011 Nov;58(6-7):455-63 21906611 Prostaglandins. 1984 Apr;27(4):553-62 6427852 Toxins (Basel). 2017 Dec 19;9(12): 29311537 J Biol Chem. 1987 Oct 25;262(30):14402-7 3117784 31985944 NBK553151 StatPearls Publishing Treasure Island (FL) StatPearls 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

5.  Phospholipase A2 from krait Bungarus fasciatus venom induces human cancer cell death in vitro.LinkIT
Tran TV, Siniavin AE, Hoang AN, Le MTT, Pham CD, Phung TV, Nguyen KC, Ziganshin RH, Tsetlin VI, Weng CF, Utkin YN
PeerJ, 2019
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

6.  Can snakes use yolk reserves to maximize body size at hatching?LinkIT
Qu YF, Zhao SZ, Jiang XF, Lin LH, Ji X
Current zoology, 2019
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

7.  Longitudinal and Cross-Sectional Sampling of Serpentovirus (Nidovirus) Infection in Captive Snakes Reveals High Prevalence, Persistent Infection, and Increased Mortality in Pythons and Divergent Serpentovirus Infection in Boas and Colubrids.LinkIT
Hoon-Hanks LL, Ossiboff RJ, Bartolini P, Fogelson SB, Perry SM, Stöhr AC, Cross ST, Wellehan JFX, Jacobson ER, Dubovi EJ, Stenglein MD
Frontiers in veterinary science, 2019
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

8.  Spitting cobra (Naja nigricincta nigricincta) bites complicated by rhabdomyolysis, possible intravascular haemolysis, and coagulopathy.LinkIT
Saaiman EL, Buys PJC
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2019
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

9.  Taxonomy of the Micrurus spixii species complex (Serpentes, Elapidae).LinkIT
Nascimento LRS, Silva NJJ, Feitosa DT, Prudente ALC
Zootaxa, 2019
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0



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