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uBio  Web  Results 1 - 10 of about 914 Scientific:    Epinephelus caninus (Dott iswed)  Synonyms:    Epinephelus caninus (dogtooth grouper)     Serranus caninus  Broader Terms:    Dott     Epinephelus (groupers)     Perciformes (perch-like fishes)     Serranus      Latest Articles on Dott iswed from uBioRSS Genetic characterization of eastern Atlantic hawksbill turtles at a foragin... - ScienceDirect Search: species External Resources: 1.  Group sequential designs for clinical trials with bivariate endpoints. Hu J, Blatchford PJ, Goldenberg NA, Kittelson JM Statistics in medicine Stat Med Group sequential designs for clinical trials with bivariate endpoints. 3823-3839 10.1002/sim.8696 Although all clinical trials are designed and monitored using more than one endpoint, methods are needed to assure that decision criteria are chosen to reflect the clinically relevant tradeoffs that assure the trial's scientific integrity. This article presents a framework for the design and monitoring clinical trials in a bivariate outcome space. The framework uses a rectangular hyperbola to define a bivariate null curve that divides outcome space into regions of benefit and lack of benefit. The curve is shown to be a flexible mapping of bivariate space that allows a continuous tradeoff between the two endpoints in a manner that captures many previous bivariate designs. The curve is extended to a distance function in bivariate space that allows different decisions in each of the four quadrants that comprise bivariate space. The distance function forms a statistic ( ? ); the distribution of its estimate is derived and used as a basis for trial design and group sequential monitoring plans in bivariate space. A recursive form of the bivariate group sequential density is used to evaluate and control operating characteristics for the proposed design. The bivariate designs are shown to meet or exceed the usual standards for size and power. The proposed design is illustrated in the ongoing NHLBI-sponsored Kids-DOTT multinational randomized controlled trial comparing shortened versus conventional anticoagulation for the treatment of venous thromboembolism in patients less than 21 years of age. The proposed methods are broadly applicable to a wide range of clinical settings and trial designs. © 2020 John Wiley & Sons, Ltd. Hu Junxiao J Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Blatchford Patrick J PJ Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Goldenberg Neil A NA Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Thrombosis Program, Johns Hopkins All Children's Cancer and Blood Disorders Institute, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA. Johns Hopkins All Children's Institute for Clinical and Translational Research, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA. Kittelson John M JM https://orcid.org/0000-0002-4929-1414 Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. eng 5U01HL130219-04 HL NHLBI NIH HHS United States Journal Article 2020 08 10 England Stat Med 8215016 0277-6715 IM cardiovascular disease causal pathway multiple endpoints surrogate endpoint 2019 10 25 2020 06 17 2020 06 20 2020 10 13 12 14 2020 10 14 6 0 2020 10 14 6 0 ppublish 33048360 10.1002/sim.8696