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Synonyms:
   Acacia carneorum (Neddle Wattle (Au)) 
   Chorda filum (Sea Lace) 

Broader Terms:
   Chorda 
   Dead 
   Laminariales 

More Specific:
   Chorda filum crassipes 
 
 


Chorda filum
Guiamarina

External Resources:



1.  First clinical-grade porcine kidney xenotransplant using a human decedent model.LinkIT
Porrett PM, Orandi BJ, Kumar V, Houp J, Anderson D, Cozette Killian A, Hauptfeld-Dolejsek V, Martin DE, Macedon S, Budd N, Stegner KL, Dandro A, Kokkinaki M, Kuravi KV, Reed RD, Fatima H, Killian JT, Baker G, Perry J, Wright ED, Cheung MD, Erman EN, Kraebber K, Gamblin T, Guy L, George JF, Ayares D, Locke JE
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsAm J TransplantFirst clinical-grade porcine kidney xenotransplant using a human decedent model.10.1111/ajt.16930A radical solution is needed for the organ supply crisis, and the domestic pig is a promising organ source. In preparation for a clinical trial of xenotransplantation, we developed an in vivo pre-clinical human model to test safety and feasibility tenets established in animal models. After performance of a novel, prospective compatible crossmatch, we performed bilateral native nephrectomies in a human brain-dead decedent and subsequently transplanted two kidneys from a pig genetically engineered for human xenotransplantation. The decedent was hemodynamically stable through reperfusion, and vascular integrity was maintained despite the exposure of the xenografts to human blood pressure. No hyperacute rejection was observed, and the kidneys remained viable until termination 74 h later. No chimerism or transmission of porcine retroviruses was detected. Longitudinal biopsies revealed thrombotic microangiopathy that did not progress in severity, without evidence of cellular rejection or deposition of antibody or complement proteins. Although the xenografts produced variable amounts of urine, creatinine clearance did not recover. Whether renal recovery was impacted by the milieu of brain death and/or microvascular injury remains unknown. In summary, our study suggests that major barriers to human xenotransplantation have been surmounted and identifies where new knowledge is needed to optimize xenotransplantation outcomes in humans.© 2022 The American Society of Transplantation and the American Society of Transplant Surgeons.PorrettPaige MPMhttps://orcid.org/0000-0002-6895-5597University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.OrandiBabak JBJhttps://orcid.org/0000-0001-6026-7135University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.KumarVineetaVhttps://orcid.org/0000-0002-4271-463XUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.HoupJulieJUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.AndersonDouglasDUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.Cozette KillianAAUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.Hauptfeld-DolejsekVeraVUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.MartinDominque EDEDeakin University School of Medicine, Geelong, Victoria, Australia.MacedonSaraSUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.BuddNatalieNUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.StegnerKatherine LKLUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.DandroAmyARevivicor, Inc, Blacksburg, Virginia, USA.KokkinakiMariaMRevivicor, Inc, Blacksburg, Virginia, USA.KuraviKasinath VKVRevivicor, Inc, Blacksburg, Virginia, USA.ReedRhiannon DRDUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.FatimaHumaHUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.KillianJohn TJTJrUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.BakerGavinGUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.PerryJacksonJUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.WrightEmma DEDUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.CheungMatthew DMDhttps://orcid.org/0000-0003-4182-5220University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.ErmanElise NENUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.KraebberKarlKUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.GamblinTracyTUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.GuyLindaLUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.GeorgeJames FJFUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.AyaresDavidDRevivicor, Inc, Blacksburg, Virginia, USA.LockeJayme EJEhttps://orcid.org/0000-0002-0220-8716University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.engUnited Therapeutics CorporationJournal Article20220120United StatesAm J Transplant1009686381600-6135IMclinical research/practicegeneticskidney transplantation/nephrologytranslational research/sciencexenoantigenxenotransplantation2021121520211207202112162022120913202212160202212160aheadofprint3504912110.1111/ajt.16930REFERENCES, 2022</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>2.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Landscape context and substrate characteristics shape fungal communities of dead spruce in urban and semi-natural forests.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Korhonen A, Miettinen O, Kotze JD, Hamberg L<br><font color=gray><i>Environmental microbiology, 2022</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>3.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Brazilian green propolis reduces worm burden and hepatic granuloma formation in a Schistosoma mansoni experimental murine model.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>de L Paula LA, Santos MFC, Pagotti MC, Veneziani RCS, Bastos JK, Caffrey CR, Ambrósio SR, Magalhães LG<br><font color=gray><i>Parasitology research, 2022</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>4.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Genetics of resistance to septoria nodorum blotch in wheat.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Peters Haugrud AR, Zhang Z, Friesen TL, Faris JD<br><font color=gray><i>TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2022</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>5.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Reassessment of <i>Dyfrolomyces</i> and Four New Species of <i>Melomastia</i> from Olive (<i>Olea europaea</i>) in Sichuan Province, China.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Li WL, Maharachchikumbura SSN, Cheewangkoon R, Liu JK<br><font color=gray><i>Journal of fungi (Basel, Switzerland), 2022</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>6.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Chitosan/Pluronic F127 Thermosensitive Hydrogel as an Injectable Dexamethasone Delivery Carrier.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>García-Couce J, Tomás M, Fuentes G, Que I, Almirall A, Cruz LJ<br><font color=gray><i>Gels (Basel, Switzerland), 2022</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>7.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Prognostic Ferroptosis-Related lncRNA Signatures Associated With Immunotherapy and Chemotherapy Responses in Patients With Stomach Cancer.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Lai D, Tan L, Zuo X, Liu D, Jiao D, Wan G, Lu C, Shen D, Gu X<br><font color=gray><i>Frontiers in genetics, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>8.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Exploring the Abilities of Peripheral Autonomic Parameters to Describe Pain: Another Dead End?</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Argüello E, Bermeo L, Castillo 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href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>A simple nomogram identifies patients with refractory ascites with worse outcome after transjugular intrahepatic portosystemic shunt.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Aicart-Ramos M, Ibáñez-Samaniego L, Hernández-Gea V, Martínez-Lozano H, Rodríguez-de-Santiago E, Catalina MV, Martínez González J, Echenagusia-Boyra MJ, Mezzano Puentes G, Ferrusquía-Acosta J, Olavarría A, Blázquez Sánchez J, García-Pagán JC, Bañares R, Albillos A<br><font color=gray><i>European journal of gastroenterology & hepatology, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br><br><br><table cellspacing=0 cellpadding=0 align=center><tr valign=bottom><td align=center><img src=p.png border=0></td><td align=center><img src=o_red.png border=0></td><td align=center><a href=http://ubio.org/portal/index.php?search=Dead+Man%27s+Ropes&category=l&client=pubmed&startPage=2><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Dead+Man%27s+Ropes&category=l&client=pubmed&startPage=3><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Dead+Man%27s+Ropes&category=l&client=pubmed&startPage=4><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Dead+Man%27s+Ropes&category=l&client=pubmed&startPage=5><img src=o_yellow.png border=0></a></td><td align=center><a 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