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Spatial-Temporal Analysis of Cache Valley Virus (Bunyaviridae: Orthobunyavi... - PubMed: species
Isolation and complete nucleotide sequence of a Batai virus strain in Inner... - Virology Journal


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1.  An evaluation of suspected cases of Hantavirus infection admitted to a tertiary care university hospital in Düzce, Turkey, between 2012 and 2018.LinkIT
?nce N, ÖneÇ K, Sav T, Sungur MA, Menemenl?o?lu D
Turkish journal of medical sciences, 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

2.  Clinical manifestations of death with severe fever and thrombocytopenia syndrome: A meta-analysis and systematic review. 10.1002/jmv.26518 Severe hemorrhagic fever disease is caused by severe fever with thrombocytopenia syndrome virus (SFTSV) infection, which belongs to the Phlebovirus genus in the Bunyaviridae family. A comprehensive literature search of PubMed, Web of Science, Embase, Cochrane Library, Chinese National Knowledge Infrastructure databases, Wan Fang Data, Sinomed Database, and VIP database was conducted for articles which have described the clinical manifestation of deceased patients. Data from selected studies were pooled by using STATA VERSION 15.0 software. Finally, 29 articles comprising 4717 laboratory-confirmed SFTSV cases were included in this analysis. We found there were significant differences between the two groups for fatigue, headache, underlying disease, vomiting, diarrhea, skin bleeding, neurological symptoms, arrhythmia, diffuse intravascular coagulation, and multiple organ failure. There were some significant differences between the fatal and nonfatal groups, and we need to pay more attention to the above symptoms to distinguish between fatal and nonfatal patients. © 2020 Wiley Periodicals LLC. Wang Xiankun X http://orcid.org/0000-0002-0777-3300 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Ren Xingxiang X http://orcid.org/0000-0002-5140-1256 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Ge Ziruo Z http://orcid.org/0000-0002-6423-7205 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Cui Shuping S http://orcid.org/0000-0002-9518-6471 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Wang Lin L http://orcid.org/0000-0002-8857-0379 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Chen Zhihai Z http://orcid.org/0000-0001-6481-4781 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Tian Di D http://orcid.org/0000-0002-8260-8575 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. eng 2018ZX09711003 National Science and Technology Major Project of China Journal Article 2020 09 15 United States J Med Virol 7705876 0146-6615 IM death features meta-analysis severe fever with thrombocytopenia syndrome 2020 08 07 2020 09 11 2020 09 12 2020 9 16 6 0 2020 9 16 6 0 2020 9 15 8 53 aheadofprint 32930400 10.1002/jmv.26518 REFERENCES Zhan J, Wang Q, Cheng J, et al. Current status of severe fever with thrombocytopenia syndrome in China. Virol Sin 2017;32:51-62. Chen C, Li P, Li KF, et al. Animals as amplification hosts in the spread of severe fever with thrombocytopenia syndrome virus: a systematic review and meta-analysis. Int J Infect Dis. 2019;79:77-84. Jiang XL, Zhang S, Jiang M, et al. A cluster of person-to-person transmission cases caused by SFTS virus in Penglai, China. Clin Microbiol Infect. 2015;21:274-279. Liu M, Lei XY, Yu X. Meta-analysis of the clinical and laboratory parameters of SFTS patients in China. Virol J. 2016;13:198. Li H, Lu QB, Xing B, et al. Epidemiological and clinical features of laboratory-diagnosed severe fever with thrombocytopenia syndrome in China, 2011-17: a prospective observational study. Lancet Infect Dis. 2018;18:1127-1137. Zhang Y, Song R, Shen Y, et al. High levels of circulating cell-free DNA are associated with a poor prognosis in patients with severe fever with thrombocytopenia syndrome. Clin Infect Dis. 2020;5(70):1941-1949. Mcmullan LK, Folk SM, Kelly AJ, et al. A new phlebovirus associated with severe febrile illness in Missouri. N Engl J Med. 2012;30:367834-841. Zhang SF, Yang ZD, Huang ML, et al. Preexisting chronic conditions for fatal outcome among SFTS patients: an observational cohort study. PLOS Negl Trop Dis. 2019;13:e0007434. Alsadeq DW, Taleb SA, Zaied RE, et al. Hepatitis B virus molecular epidemiology, host-virus interaction, coinfection, and laboratory diagnosis in the MENA region: an update. Pathogenetics. 2019;8:63. Dandri M, Locarnini S. New insight in the pathobiology of hepatitis B virus infection. Gut. 2012;61:i6-i17. Suzuki T, Sato Y, Sano K, et al. Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections. J Clin Invest. 2020;130:799-812. Ning YJ, Feng K, Min YQ, et al. Disruption of type I interferon signaling by the nonstructural protein of severe fever with thrombocytopenia syndrome virus via the hijacking of STAT2 and STAT1 into inclusion bodies. J Virol. 2015;89:4227-4236. Karan A, Bhakkiyalakshmi E, Jayasuriya R, Sarada DVL, Ramkumar KM. The pivotal role of nuclear factor erythroid 2-related factor 2 in diabetes-induced endothelial dysfunction. Pharmacol Res. 2020;153:104601. Li XK, Yang ZD, Du J, et al. Endothelial activation and dysfunction in severe fever with thrombocytopenia syndrome. PLOS Negl Trop Dis. 2017;11:e0005746. Cui N, Liu R, Lu QB, et al. Severe fever with thrombocytopenia syndrome bunyavirus-related human encephalitis. J Infect. 2015;70:52-59. Park SY, Kwon JS, Kim JY, et al. Severe fever with thrombocytopenia syndrome-associated encephalopathy/encephalitis. Clin Microbiol Infect. 2018;24:432-432.e4. Wang L, Wan G, Shen Y, et al. A nomogram to predict mortality in patients with severe fever with thrombocytopenia syndrome at the early stage-A multicenter study in China. PLOS Neglect Trop D. 2019;13:e0007829. Jung IY, Ahn K, Kim J, et al. Higher fatality for severe fever with thrombocytopenia syndrome complicated by hemophagocytic lymphohistiocytosis. Yonsei Med J. 2019;60:592-596. Kim J, Bae J. Epidemiological and clinical characteristics of confirmed cases of severe fever with thrombocytopenia syndrome in Jeju Province, Korea, 2014-2018. J Prev Med Public Health. 2019;52:195-199. Sheng Q, Sheng J, Zhang X, et al. Clinical characteristics and prognostic factors of 25 patients with new bunyavirus infection. Chin J Exp Clin Infect Dis. 2019;12:152-157. Ning L, Jing K, Liu L, et al. Analysis of clinical epidemiological characteristics and risk factors for death of new Bunia virus infection. Anhui Med J. 2019;40:65-66. Hu J, Li S, Zhang X, et al. Correlations between clinical features and death in patients with severe fever with thrombocytopenia syndrome. Medicine. 2018;97:e10848. Jia B, Wu W, Huang R, et al. Characterization of clinical features and outcome for human-to-human transmitted severe fever with thrombocytopenia syndrome. Infect Dis-Nor. 2018;50:601-608. Xu X, Sun Z, Liu J, et al. Analysis of clinical features and early warning indicators of death from severe fever with thrombocytopenia syndrome. Int J Infect Dis. 2018;73:43-48. Liu J, Feng J, Li A, et al. Analysis of clinical characteristics and death risk factors in patients infected with severe fever with thrombocytopenia syndrome bunyavirus. Chin J Postgrad Med. 2018;41:429-433. Yang Y, Ye J, Li H, et al. Investigation of clinical characteristics and prognosis of severe fever with thrombocytopenia syndrome: 69 cases analysis. Chin J Dis Con Pre. 2018;4:402-405. Xia G, Zhou G, Ye J, et al. Clinical features and prognostic factors of fever with thrombocytopenia syndrome in Anhui area. Anhui Med J. 2018;39:854-857. Yu N, Wang Q, Yu Q, et al. Blood gas analysis and biochemical parameters in survival patients and death patients with severe fever with thrombocytopenia syndrome after tracheal intubation. Chin J Clin Inf Dis. 2018;11:213-216. Xing B, Li XK, Zhang SF, et al. Polymorphisms and haplotypes in the promoter of the TNF-? gene are associated with disease severity of severe fever with thrombocytopenia syndrome in Chinese Han population. PLOS Neglect Trop Dis. 2018;12:e0006547. Li Z, Hu J, Cui L, et al. Increased prevalence of severe fever with thrombocytopenia syndrome in eastern China clustered with multiple genotypes and reasserted virus during 2010-2015. Sci Rep. 2017;7:6503-6503. Yang B, Wang X, Li Y, et al. A newly established severity scoring system in predicting the prognosis of patients with severe fever with thrombocytopenia syndrome. Tohoku J Exp Med. 2017;242:19-25. Wang L, Zou Z, Hou C, Liu X, Jiang F, Yu H. Score risk model for predicting severe fever with thrombocytopenia syndrome mortality. BMC Infect Dis. 2017;17:42. Zhang H, Liu X, Ni X. Clinical analysis of 59 cases with fever and thrombocytopenia syndrome in elderly patients with multiple organ dysfunction syndrome. Chin J Exp Clin Infect Dis. 2017;11:69-71. Wang L, Liu X, Lin Q. Prognostic value of laboratory parameters in patients with severe fever with thrombocytopenia syndrome. Intern J Epi Infec Dis. 2017;44:370-373. Jia B, Yan X, Chen Y, et al. A scoring model for predicting prognosis of patients with severe fever with thrombocytopenia syndrome. PLOS Negl Trop Dis. 2017;11:e0005909. Zeng Q, Wang Q, Zhang J, et al. Risk factors for mortality in patients with severe fever with thrombocytopenia syndrome. Chin J Infe Dis. 2017;35(6):336-240. Xiong S, Zhang W, Li M, et al. A simple and practical score model for predicting the mortality of severe fever with thrombocytopenia syndrome patients. Medicine. 2016;95:e5708. Kato H, Yamagishi T, Shimada T, et al. Epidemiological and clinical features of severe fever with thrombocytopenia syndrome in Japan, 2013-2014. PLOS One. 2016;11:e0165207. Zhao H, Sun J, Yan X. Clinical characteristics and risk factors for mortality of patients with severe fever with thrombocytopenia syndrome. Chin J Infe Dis. 2016;34(1):15-18. Xu H, Zhao H. Analysis on surveillance data of severe fever with thrombocytopenia syndrome in Jinan city in 2011-2015. Mod Prev Med. 2016;18:3419-3422. Shin J, Kwon D, Youn SK, Park JH. Characteristics and factors associated with death among patients hospitalized for severe fever with thrombocytopenia syndrome, South Korea, 2013. Emerg Infect Dis. 2015;21:1704-1710. Zhang XA, Guo CT, Lu QB, et al. The platelet derived growth factor-B polymorphism is associated with risk of severe fever with thrombocytopenia syndrome in Chinese individuals. Oncotarget. 2016;7:33340-33349. Li J, Han Y, Xing Y, et al. Concurrent measurement of dynamic changes in viral load, serum enzymes, T cell subsets, and cytokines in patients with severe fever with thrombocytopenia syndrome. PLOS One. 2014;9:e91679. Deng B, Zhou B, Zhang S, et al. Clinical features and factors associated with severity and fatality among patients with severe fever with thrombocytopenia syndrome bunyavirus infection in northeast China. PLOS One. 2013;8:e80802. Gai ZT, Zhang Y, Liang MF, et al. Clinical progress and risk factors for death in severe fever with thrombocytopenia syndrome patients. J Infect Dis. 2012;206:1095-1102. 32965919 NBK562248 StatPearls Publishing Treasure Island (FL) StatPearls 2020 01 2020 01 Internet La Crosse Encephalitis eng Khan Usaamah M. UM Virginia Commonwealth University Health System Gudlavalleti Aashrai A Govt. Kilpauk Medical College Review La Crosse encephalitis is a mosquito-borne arboviral disease that is most commonly seen in the mid-Atlantic and midwestern areas of the United States. The disease gets its name from La Crosse County in Wisconsin, where the illness was first observed by physicians in the 1960s.[1] The physicians noted what was described as an encephalitis syndrome in children, usually around the summertime. It is currently the most commonly reported pediatric arboviral encephalitis.[2] The illness results from the La Crosse virus, which is part of the Bunyaviridae family of the California serogroup 18,19,20,45, and is spread via transmission from the eastern treehole mosquito, also known as Aedes triseriatus. This mosquito is recognized as the primary host and vector for the La Crosse virus.[3] Two other species of mosquitos, the Aedes albopictus as well as the Aedes japonicus, have also been identified as vectors in the transmission of the La Crosse virus and likely play an emerging role in the maintenance of the virus in endemic areas.[2] Copyright © 2020, StatPearls Publishing LLC.
Introduction
Etiology
Epidemiology
Pathophysiology
Histopathology
History and Physical
Evaluation
Treatment / Management
Differential Diagnosis
Prognosis
Complications
Deterrence and Patient Education
Enhancing Healthcare Team Outcomes
Continuing Education / Review Questions
References
2020 8 21
2020 9 24 6 1 2020 9 24 6 1 2020 9 24 6 1 ppublish 32965919
32809552 NBK560717 StatPearls Publishing Treasure Island (FL) StatPearls 2020 01 2020 01 Internet Viral Hemorrhagic Fevers eng Mangat Rupinder R University of Rochester Medical Center Louie Ted T University of Rochester Medical Center Review Viral hemorrhagic fevers (VHFs) represent a group of severe systemic febrile illnesses caused by four families of viruses - ArenaviridaeBunyaviridaeFiloviridae, and Flaviviridae.[1] These enveloped viruses are characterized by a myriad of symptoms that range from coagulopathies, hemodynamic instability, altered mental status, and, if severe enough, death. The degree of clinical illness can vary widely with some viruses causing mild illness, while others can be life-threatening. Most of the viruses implicated in these diseases require vectors for transmission to humans, with the majority being arthropod-borne or rodent-borne infections. Given their zoonotic nature, these diseases are generally confined to the endemic areas where their hosts live. However, given increased human migration and further globalization, these diseases are no longer limited to their geographic origins.[2] This article will provide a general overview of viral hemorrhagic fevers and focus on those diseases which have the highest overall mortality rates. Copyright © 2020, StatPearls Publishing LLC.
Introduction
Etiology
Epidemiology
Pathophysiology
History and Physical
Evaluation
Treatment / Management
Differential Diagnosis
Prognosis
Complications
Deterrence and Patient Education
Pearls and Other Issues
Enhancing Healthcare Team Outcomes
Continuing Education / Review Questions
References
2020 8 16
2020 8 19 6 1 2020 8 19 6 1 2020 8 19 6 1 ppublish 32809552
32809701 NBK560866 StatPearls Publishing Treasure Island (FL) StatPearls 2020 01 2020 01 Internet Arbovirus Encephalitides
LinkIT
Wang X, Ren X, Ge Z, Cui S, Wang L, Chen Z, Tian D, , Khan UM, Gudlavalleti A, , Mangat R, Louie T, , Mangat R, Louie T
Journal of medical virology J Med Virol Clinical manifestations of death with severe fever and thrombocytopenia syndrome: A meta-analysis and systematic review. 10.1002/jmv.26518 Severe hemorrhagic fever disease is caused by severe fever with thrombocytopenia syndrome virus (SFTSV) infection, which belongs to the Phlebovirus genus in the Bunyaviridae family. A comprehensive literature search of PubMed, Web of Science, Embase, Cochrane Library, Chinese National Knowledge Infrastructure databases, Wan Fang Data, Sinomed Database, and VIP database was conducted for articles which have described the clinical manifestation of deceased patients. Data from selected studies were pooled by using STATA VERSION 15.0 software. Finally, 29 articles comprising 4717 laboratory-confirmed SFTSV cases were included in this analysis. We found there were significant differences between the two groups for fatigue, headache, underlying disease, vomiting, diarrhea, skin bleeding, neurological symptoms, arrhythmia, diffuse intravascular coagulation, and multiple organ failure. There were some significant differences between the fatal and nonfatal groups, and we need to pay more attention to the above symptoms to distinguish between fatal and nonfatal patients. © 2020 Wiley Periodicals LLC. Wang Xiankun X http://orcid.org/0000-0002-0777-3300 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Ren Xingxiang X http://orcid.org/0000-0002-5140-1256 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Ge Ziruo Z http://orcid.org/0000-0002-6423-7205 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Cui Shuping S http://orcid.org/0000-0002-9518-6471 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Wang Lin L http://orcid.org/0000-0002-8857-0379 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Chen Zhihai Z http://orcid.org/0000-0001-6481-4781 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Tian Di D http://orcid.org/0000-0002-8260-8575 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. eng 2018ZX09711003 National Science and Technology Major Project of China Journal Article 2020 09 15 United States J Med Virol 7705876 0146-6615 IM death features meta-analysis severe fever with thrombocytopenia syndrome 2020 08 07 2020 09 11 2020 09 12 2020 9 16 6 0 2020 9 16 6 0 2020 9 15 8 53 aheadofprint 32930400 10.1002/jmv.26518 REFERENCES, 2020</Year> <Month>Sep</Month> <Day>15</Day> </PubDate> </JournalIssue> <Title>Journal of medical virology J Med Virol Clinical manifestations of death with severe fever and thrombocytopenia syndrome: A meta-analysis and systematic review. 10.1002/jmv.26518 Severe hemorrhagic fever disease is caused by severe fever with thrombocytopenia syndrome virus (SFTSV) infection, which belongs to the Phlebovirus genus in the Bunyaviridae family. A comprehensive literature search of PubMed, Web of Science, Embase, Cochrane Library, Chinese National Knowledge Infrastructure databases, Wan Fang Data, Sinomed Database, and VIP database was conducted for articles which have described the clinical manifestation of deceased patients. Data from selected studies were pooled by using STATA VERSION 15.0 software. Finally, 29 articles comprising 4717 laboratory-confirmed SFTSV cases were included in this analysis. We found there were significant differences between the two groups for fatigue, headache, underlying disease, vomiting, diarrhea, skin bleeding, neurological symptoms, arrhythmia, diffuse intravascular coagulation, and multiple organ failure. There were some significant differences between the fatal and nonfatal groups, and we need to pay more attention to the above symptoms to distinguish between fatal and nonfatal patients. © 2020 Wiley Periodicals LLC. Wang Xiankun X http://orcid.org/0000-0002-0777-3300 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Ren Xingxiang X http://orcid.org/0000-0002-5140-1256 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Ge Ziruo Z http://orcid.org/0000-0002-6423-7205 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Cui Shuping S http://orcid.org/0000-0002-9518-6471 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Wang Lin L http://orcid.org/0000-0002-8857-0379 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Chen Zhihai Z http://orcid.org/0000-0001-6481-4781 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Tian Di D http://orcid.org/0000-0002-8260-8575 Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. eng 2018ZX09711003 National Science and Technology Major Project of China Journal Article 2020 09 15 United States J Med Virol 7705876 0146-6615 IM death features meta-analysis severe fever with thrombocytopenia syndrome 2020 08 07 2020 09 11 2020 09 12 2020 9 16 6 0 2020 9 16 6 0 2020 9 15 8 53 aheadofprint 32930400 10.1002/jmv.26518 REFERENCES Zhan J, Wang Q, Cheng J, et al. Current status of severe fever with thrombocytopenia syndrome in China. Virol Sin 2017;32:51-62. Chen C, Li P, Li KF, et al. Animals as amplification hosts in the spread of severe fever with thrombocytopenia syndrome virus: a systematic review and meta-analysis. Int J Infect Dis. 2019;79:77-84. Jiang XL, Zhang S, Jiang M, et al. A cluster of person-to-person transmission cases caused by SFTS virus in Penglai, China. Clin Microbiol Infect. 2015;21:274-279. Liu M, Lei XY, Yu X. Meta-analysis of the clinical and laboratory parameters of SFTS patients in China. Virol J. 2016;13:198. Li H, Lu QB, Xing B, et al. Epidemiological and clinical features of laboratory-diagnosed severe fever with thrombocytopenia syndrome in China, 2011-17: a prospective observational study. Lancet Infect Dis. 2018;18:1127-1137. Zhang Y, Song R, Shen Y, et al. High levels of circulating cell-free DNA are associated with a poor prognosis in patients with severe fever with thrombocytopenia syndrome. Clin Infect Dis. 2020;5(70):1941-1949. Mcmullan LK, Folk SM, Kelly AJ, et al. A new phlebovirus associated with severe febrile illness in Missouri. N Engl J Med. 2012;30:367834-841. Zhang SF, Yang ZD, Huang ML, et al. Preexisting chronic conditions for fatal outcome among SFTS patients: an observational cohort study. PLOS Negl Trop Dis. 2019;13:e0007434. Alsadeq DW, Taleb SA, Zaied RE, et al. Hepatitis B virus molecular epidemiology, host-virus interaction, coinfection, and laboratory diagnosis in the MENA region: an update. Pathogenetics. 2019;8:63. Dandri M, Locarnini S. New insight in the pathobiology of hepatitis B virus infection. Gut. 2012;61:i6-i17. Suzuki T, Sato Y, Sano K, et al. Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections. J Clin Invest. 2020;130:799-812. Ning YJ, Feng K, Min YQ, et al. Disruption of type I interferon signaling by the nonstructural protein of severe fever with thrombocytopenia syndrome virus via the hijacking of STAT2 and STAT1 into inclusion bodies. J Virol. 2015;89:4227-4236. Karan A, Bhakkiyalakshmi E, Jayasuriya R, Sarada DVL, Ramkumar KM. The pivotal role of nuclear factor erythroid 2-related factor 2 in diabetes-induced endothelial dysfunction. Pharmacol Res. 2020;153:104601. Li XK, Yang ZD, Du J, et al. Endothelial activation and dysfunction in severe fever with thrombocytopenia syndrome. PLOS Negl Trop Dis. 2017;11:e0005746. Cui N, Liu R, Lu QB, et al. Severe fever with thrombocytopenia syndrome bunyavirus-related human encephalitis. J Infect. 2015;70:52-59. Park SY, Kwon JS, Kim JY, et al. Severe fever with thrombocytopenia syndrome-associated encephalopathy/encephalitis. Clin Microbiol Infect. 2018;24:432-432.e4. Wang L, Wan G, Shen Y, et al. A nomogram to predict mortality in patients with severe fever with thrombocytopenia syndrome at the early stage-A multicenter study in China. PLOS Neglect Trop D. 2019;13:e0007829. Jung IY, Ahn K, Kim J, et al. Higher fatality for severe fever with thrombocytopenia syndrome complicated by hemophagocytic lymphohistiocytosis. Yonsei Med J. 2019;60:592-596. Kim J, Bae J. Epidemiological and clinical characteristics of confirmed cases of severe fever with thrombocytopenia syndrome in Jeju Province, Korea, 2014-2018. J Prev Med Public Health. 2019;52:195-199. Sheng Q, Sheng J, Zhang X, et al. Clinical characteristics and prognostic factors of 25 patients with new bunyavirus infection. Chin J Exp Clin Infect Dis. 2019;12:152-157. Ning L, Jing K, Liu L, et al. Analysis of clinical epidemiological characteristics and risk factors for death of new Bunia virus infection. Anhui Med J. 2019;40:65-66. Hu J, Li S, Zhang X, et al. Correlations between clinical features and death in patients with severe fever with thrombocytopenia syndrome. Medicine. 2018;97:e10848. Jia B, Wu W, Huang R, et al. Characterization of clinical features and outcome for human-to-human transmitted severe fever with thrombocytopenia syndrome. Infect Dis-Nor. 2018;50:601-608. Xu X, Sun Z, Liu J, et al. Analysis of clinical features and early warning indicators of death from severe fever with thrombocytopenia syndrome. Int J Infect Dis. 2018;73:43-48. Liu J, Feng J, Li A, et al. Analysis of clinical characteristics and death risk factors in patients infected with severe fever with thrombocytopenia syndrome bunyavirus. Chin J Postgrad Med. 2018;41:429-433. Yang Y, Ye J, Li H, et al. Investigation of clinical characteristics and prognosis of severe fever with thrombocytopenia syndrome: 69 cases analysis. Chin J Dis Con Pre. 2018;4:402-405. Xia G, Zhou G, Ye J, et al. Clinical features and prognostic factors of fever with thrombocytopenia syndrome in Anhui area. Anhui Med J. 2018;39:854-857. Yu N, Wang Q, Yu Q, et al. Blood gas analysis and biochemical parameters in survival patients and death patients with severe fever with thrombocytopenia syndrome after tracheal intubation. Chin J Clin Inf Dis. 2018;11:213-216. Xing B, Li XK, Zhang SF, et al. Polymorphisms and haplotypes in the promoter of the TNF-? gene are associated with disease severity of severe fever with thrombocytopenia syndrome in Chinese Han population. PLOS Neglect Trop Dis. 2018;12:e0006547. Li Z, Hu J, Cui L, et al. Increased prevalence of severe fever with thrombocytopenia syndrome in eastern China clustered with multiple genotypes and reasserted virus during 2010-2015. Sci Rep. 2017;7:6503-6503. Yang B, Wang X, Li Y, et al. A newly established severity scoring system in predicting the prognosis of patients with severe fever with thrombocytopenia syndrome. Tohoku J Exp Med. 2017;242:19-25. Wang L, Zou Z, Hou C, Liu X, Jiang F, Yu H. Score risk model for predicting severe fever with thrombocytopenia syndrome mortality. BMC Infect Dis. 2017;17:42. Zhang H, Liu X, Ni X. Clinical analysis of 59 cases with fever and thrombocytopenia syndrome in elderly patients with multiple organ dysfunction syndrome. Chin J Exp Clin Infect Dis. 2017;11:69-71. Wang L, Liu X, Lin Q. Prognostic value of laboratory parameters in patients with severe fever with thrombocytopenia syndrome. Intern J Epi Infec Dis. 2017;44:370-373. Jia B, Yan X, Chen Y, et al. A scoring model for predicting prognosis of patients with severe fever with thrombocytopenia syndrome. PLOS Negl Trop Dis. 2017;11:e0005909. Zeng Q, Wang Q, Zhang J, et al. Risk factors for mortality in patients with severe fever with thrombocytopenia syndrome. Chin J Infe Dis. 2017;35(6):336-240. Xiong S, Zhang W, Li M, et al. A simple and practical score model for predicting the mortality of severe fever with thrombocytopenia syndrome patients. Medicine. 2016;95:e5708. Kato H, Yamagishi T, Shimada T, et al. Epidemiological and clinical features of severe fever with thrombocytopenia syndrome in Japan, 2013-2014. PLOS One. 2016;11:e0165207. Zhao H, Sun J, Yan X. Clinical characteristics and risk factors for mortality of patients with severe fever with thrombocytopenia syndrome. Chin J Infe Dis. 2016;34(1):15-18. Xu H, Zhao H. Analysis on surveillance data of severe fever with thrombocytopenia syndrome in Jinan city in 2011-2015. Mod Prev Med. 2016;18:3419-3422. Shin J, Kwon D, Youn SK, Park JH. Characteristics and factors associated with death among patients hospitalized for severe fever with thrombocytopenia syndrome, South Korea, 2013. Emerg Infect Dis. 2015;21:1704-1710. Zhang XA, Guo CT, Lu QB, et al. The platelet derived growth factor-B polymorphism is associated with risk of severe fever with thrombocytopenia syndrome in Chinese individuals. Oncotarget. 2016;7:33340-33349. Li J, Han Y, Xing Y, et al. Concurrent measurement of dynamic changes in viral load, serum enzymes, T cell subsets, and cytokines in patients with severe fever with thrombocytopenia syndrome. PLOS One. 2014;9:e91679. Deng B, Zhou B, Zhang S, et al. Clinical features and factors associated with severity and fatality among patients with severe fever with thrombocytopenia syndrome bunyavirus infection in northeast China. PLOS One. 2013;8:e80802. Gai ZT, Zhang Y, Liang MF, et al. Clinical progress and risk factors for death in severe fever with thrombocytopenia syndrome patients. J Infect Dis. 2012;206:1095-1102. 32965919 NBK562248 StatPearls Publishing Treasure Island (FL) StatPearls 2020 01 2020 01 Internet La Crosse Encephalitis eng Khan Usaamah M. UM Virginia Commonwealth University Health System Gudlavalleti Aashrai A Govt. Kilpauk Medical College Review La Crosse encephalitis is a mosquito-borne arboviral disease that is most commonly seen in the mid-Atlantic and midwestern areas of the United States. The disease gets its name from La Crosse County in Wisconsin, where the illness was first observed by physicians in the 1960s.[1] The physicians noted what was described as an encephalitis syndrome in children, usually around the summertime. It is currently the most commonly reported pediatric arboviral encephalitis.[2] The illness results from the La Crosse virus, which is part of the Bunyaviridae family of the California serogroup 18,19,20,45, and is spread via transmission from the eastern treehole mosquito, also known as Aedes triseriatus. This mosquito is recognized as the primary host and vector for the La Crosse virus.[3] Two other species of mosquitos, the Aedes albopictus as well as the Aedes japonicus, have also been identified as vectors in the transmission of the La Crosse virus and likely play an emerging role in the maintenance of the virus in endemic areas.[2] Copyright © 2020, StatPearls Publishing LLC.
Introduction
Etiology
Epidemiology
Pathophysiology
Histopathology
History and Physical
Evaluation
Treatment / Management
Differential Diagnosis
Prognosis
Complications
Deterrence and Patient Education
Enhancing Healthcare Team Outcomes
Continuing Education / Review Questions
References
2020 8 21
2020 9 24 6 1 2020 9 24 6 1 2020 9 24 6 1 ppublish 32965919
32809552 NBK560717 StatPearls Publishing Treasure Island (FL) StatPearls 2020 01 2020 01 Internet Viral Hemorrhagic Fevers eng Mangat Rupinder R University of Rochester Medical Center Louie Ted T University of Rochester Medical Center Review Viral hemorrhagic fevers (VHFs) represent a group of severe systemic febrile illnesses caused by four families of viruses - ArenaviridaeBunyaviridaeFiloviridae, and Flaviviridae.[1] These enveloped viruses are characterized by a myriad of symptoms that range from coagulopathies, hemodynamic instability, altered mental status, and, if severe enough, death. The degree of clinical illness can vary widely with some viruses causing mild illness, while others can be life-threatening. Most of the viruses implicated in these diseases require vectors for transmission to humans, with the majority being arthropod-borne or rodent-borne infections. Given their zoonotic nature, these diseases are generally confined to the endemic areas where their hosts live. However, given increased human migration and further globalization, these diseases are no longer limited to their geographic origins.[2] This article will provide a general overview of viral hemorrhagic fevers and focus on those diseases which have the highest overall mortality rates. Copyright © 2020, StatPearls Publishing LLC.
Introduction
Etiology
Epidemiology
Pathophysiology
History and Physical
Evaluation
Treatment / Management
Differential Diagnosis
Prognosis
Complications
Deterrence and Patient Education
Pearls and Other Issues
Enhancing Healthcare Team Outcomes
Continuing Education / Review Questions
References
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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

3.  Biodefense Implications of New-World Hantaviruses.LinkIT
D'Souza MH, Patel TR
Frontiers in bioengineering and biotechnology, 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

4.  Severe fever with thrombocytopenia syndrome virus infection during pregnancy in C57/BL6 mice causes fetal damage. e0008453 10.1371/journal.pntd.0008453 Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne phlebovirus, which is listed in the most dangerous pathogens by the World Health Organization, and has 12-30% fatality rates. SFTSV antibodies were reported in minks that experienced abortion or reproductive failure. The aim of this study was to determine whether SFTSV infection causes an adverse pregnancy outcome in the fetus using a pregnant mouse model. We found SFTSV in the fetus after infection in pregnant mice, and some dams showed adverse pregnancy outcomes after infection with SFTSV including placental damage, fetal reabsorption, and fetal intrauterine growth restriction (IUGR). SFTSV had obvious tropism characteristics in the placenta, especially in the labyrinth. In early-gestation, pregnant mice infected with SFTSV had fetal IUGR and a high viral load in the fetus. The virus widely spread in infected fetuses, including the hindbrain, thymus, heart, spinal cord, and liver. Our study demonstrated that SFTSV was vertically transmitted to the fetus through the placental barrier of immunocompetent mice, and resulted in adverse pregnancy outcomes. Chen Rui R Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China. Kou Zeng-Qiang ZQ Shandong Center for Disease Control and Prevention, Shandong Provincial Key Laboratory of Infectious Disease Prevention and Control, Jinan, Shandong Province, China. Wang Xiao-Rui XR Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China. Li Shu-Han SH Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China. Zhang Hai-Lu HL Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China. Liu Zi-Wei ZW Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China. Cheng Dong D Shandong Center for Disease Control and Prevention, Shandong Provincial Key Laboratory of Infectious Disease Prevention and Control, Jinan, Shandong Province, China. Wang Zhi-Yu ZY Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China. Yu Xue-Jie XJ Wuhan University School of Health Sciences, Wuhan, China. Wen Hong-Ling HL 0000-0001-7405-0404 Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China. eng Journal Article Research Support, Non-U.S. Gov't 2020 07 30 United States PLoS Negl Trop Dis 101291488 1935-2727 0 Alkylating Agents 50SG953SK6 Mitomycin IM Alkylating Agents toxicity Animals Bunyaviridae Infections pathology Female Fetus abnormalities virology Immunocompromised Host Mice Mice, Inbred C57BL Mitomycin toxicity Phlebovirus Pregnancy The authors have declared that no competing interests exist. 2019 10 07 2020 06 04 2020 7 31 6 0 2020 7 31 6 0 2020 8 21 6 0 epublish 32730341 10.1371/journal.pntd.0008453 PNTD-D-19-01683 PMC7392217 Emerg Infect Dis. 2012 Jun;18(6):963-5 22608264 Dev Biol. 2002 Oct 15;250(2):358-73 12376109 J Clin Microbiol. 2014 Sep;52(9):3325-33 24989600 Emerg Infect Dis. 2013 May;19(5):756-63 23648209 Infect Control Hosp Epidemiol. 2018 Dec 19;:1-4 30565531 Vector Borne Zoonotic Dis. 2012 Feb;12(2):156-60 21955213 Am J Trop Med Hyg. 2016 Dec 7;95(6):1351-1357 27928083 Vector Borne Zoonotic Dis. 2017 Aug;17(8):596-598 28654374 PLoS One. 2016 Oct 24;11(10):e0165207 27776187 Emerg Infect Dis. 2018 Nov;24(11):2103-2105 30334706 Sci Immunol. 2019 Jan 11;4(31): 30635356 Cell. 2016 May 19;165(5):1081-1091 27180225 N Engl J Med. 2011 Apr 21;364(16):1523-32 21410387 J Gen Virol. 2012 Jun;93(Pt 6):1288-1293 22357748 Clin Infect Dis. 2011 Dec;53(12):1208-14 22028437 Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10053-8 22665769 Emerg Infect Dis. 2019 May;25(5):1029-1031 31002059 Ann Trop Paediatr. 2006 Sep;26(3):251-3 16925964 Sci Adv. 2018 Dec 05;4(12):eaau9812 30525107 Uirusu. 2015;65(1):7-16 26923953 Clin Microbiol Infect. 2019 May;25(5):633.e1-633.e4 30677496 PLoS Negl Trop Dis. 2017 Sep 22;11(9):e0005893 28937979 Sci Transl Med. 2018 Jan 31;10(426): 29386359 Lancet Infect Dis. 2018 Oct;18(10):1056-1057 30054189 32809495 NBK560660 StatPearls Publishing Treasure Island (FL) StatPearls 2020 01 2020 01 Internet Hemorrhagic Fever Renal SyndromeLinkIT
Chen R, Kou ZQ, Wang XR, Li SH, Zhang HL, Liu ZW, Cheng D, Wang ZY, Yu XJ, Wen HL, , Romero MG, Anjum F
PLoS neglected tropical diseases, 2020 07 PLoS neglected tropical diseases PLoS Negl Trop Dis Severe fever with thrombocytopenia syndrome virus infection during pregnancy in C57/BL6 mice causes fetal damage. e0008453 10.1371/journal.pntd.0008453 Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne phlebovirus, which is listed in the most dangerous pathogens by the World Health Organization, and has 12-30% fatality rates. SFTSV antibodies were reported in minks that experienced abortion or reproductive failure. The aim of this study was to determine whether SFTSV infection causes an adverse pregnancy outcome in the fetus using a pregnant mouse model. We found SFTSV in the fetus after infection in pregnant mice, and some dams showed adverse pregnancy outcomes after infection with SFTSV including placental damage, fetal reabsorption, and fetal intrauterine growth restriction (IUGR). SFTSV had obvious tropism characteristics in the placenta, especially in the labyrinth. In early-gestation, pregnant mice infected with SFTSV had fetal IUGR and a high viral load in the fetus. The virus widely spread in infected fetuses, including the hindbrain, thymus, heart, spinal cord, and liver. Our study demonstrated that SFTSV was vertically transmitted to the fetus through the placental barrier of immunocompetent mice, and resulted in adverse pregnancy outcomes. Chen Rui R Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China. Kou Zeng-Qiang ZQ Shandong Center for Disease Control and Prevention, Shandong Provincial Key Laboratory of Infectious Disease Prevention and Control, Jinan, Shandong Province, China. Wang Xiao-Rui XR Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China. Li Shu-Han SH Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China. Zhang Hai-Lu HL Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China. Liu Zi-Wei ZW Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China. Cheng Dong D Shandong Center for Disease Control and Prevention, Shandong Provincial Key Laboratory of Infectious Disease Prevention and Control, Jinan, Shandong Province, China. Wang Zhi-Yu ZY Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China. Yu Xue-Jie XJ Wuhan University School of Health Sciences, Wuhan, China. Wen Hong-Ling HL 0000-0001-7405-0404 Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China. eng Journal Article Research Support, Non-U.S. Gov't 2020 07 30 United States PLoS Negl Trop Dis 101291488 1935-2727 0 Alkylating Agents 50SG953SK6 Mitomycin IM Alkylating Agents toxicity Animals Bunyaviridae Infections pathology Female Fetus abnormalities virology Immunocompromised Host Mice Mice, Inbred C57BL Mitomycin toxicity Phlebovirus Pregnancy The authors have declared that no competing interests exist. 2019 10 07 2020 06 04 2020 7 31 6 0 2020 7 31 6 0 2020 8 21 6 0 epublish 32730341 10.1371/journal.pntd.0008453 PNTD-D-19-01683 PMC7392217 Emerg Infect Dis. 2012 Jun;18(6):963-5 22608264 Dev Biol. 2002 Oct 15;250(2):358-73 12376109 J Clin Microbiol. 2014 Sep;52(9):3325-33 24989600 Emerg Infect Dis. 2013 May;19(5):756-63 23648209 Infect Control Hosp Epidemiol. 2018 Dec 19;:1-4 30565531 Vector Borne Zoonotic Dis. 2012 Feb;12(2):156-60 21955213 Am J Trop Med Hyg. 2016 Dec 7;95(6):1351-1357 27928083 Vector Borne Zoonotic Dis. 2017 Aug;17(8):596-598 28654374 PLoS One. 2016 Oct 24;11(10):e0165207 27776187 Emerg Infect Dis. 2018 Nov;24(11):2103-2105 30334706 Sci Immunol. 2019 Jan 11;4(31): 30635356 Cell. 2016 May 19;165(5):1081-1091 27180225 N Engl J Med. 2011 Apr 21;364(16):1523-32 21410387 J Gen Virol. 2012 Jun;93(Pt 6):1288-1293 22357748 Clin Infect Dis. 2011 Dec;53(12):1208-14 22028437 Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10053-8 22665769 Emerg Infect Dis. 2019 May;25(5):1029-1031 31002059 Ann Trop Paediatr. 2006 Sep;26(3):251-3 16925964 Sci Adv. 2018 Dec 05;4(12):eaau9812 30525107 Uirusu. 2015;65(1):7-16 26923953 Clin Microbiol Infect. 2019 May;25(5):633.e1-633.e4 30677496 PLoS Negl Trop Dis. 2017 Sep 22;11(9):e0005893 28937979 Sci Transl Med. 2018 Jan 31;10(426): 29386359 Lancet Infect Dis. 2018 Oct;18(10):1056-1057 30054189 32809495 NBK560660 StatPearls Publishing Treasure Island (FL) StatPearls 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

5.  The Use of Engineered Plant Viruses in a Trans-Kingdom Silencing Strategy Against Their Insect Vectors.LinkIT
Kolliopoulou A, Kontogiannatos D, Swevers L
Frontiers in plant science, 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

6.  Enzyme-Antibody-Modified Gold Nanoparticle Probes for the Ultrasensitive Detection of Nucleocapsid Protein in SFTSV.LinkIT
Duan Y, Wu W, Zhao Q, Liu S, Liu H, Huang M, Wang T, Liang M, Wang Z
International journal of environmental research and public health, 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0



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