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Broader Terms:
   Firmicutes 

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   Bacillales 
   Bacilli affinities 
   Bacilli bacterium 
   Bacilli invertenti-acetici 
   Bacilli invertenti-acetici, 
   Bacilli invertenti-lattici 
   Bacilli invertenti-lattici, 
   Bacilli similtifo 
   Lactobacillales 
   environmental samples 
   unclassified 
 
 
Latest Articles on Bacilli from uBioRSS
A novel Bacillus pumilus -related strain from tropical landfarm soil is cap... - BMC Microbiology
DIVERSITY IN GUT MICROFLORA OF Helicoverpa armigera POPULATIONS FROM DIFFER... - Archives of Insect Biochemistry and Physiology


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111.  Antimycobacterial compound of chitosan and ethambutol: ultrastructural biological evaluation in vitro against Mycobacterium tuberculosis.LinkIT
Oliveira MEFAG, Silva YJA, Azevedo LA, Linhares LA, Montenegro LML, Alves S, Amorim RVS
Applied microbiology and biotechnologyAppl Microbiol BiotechnolAntimycobacterial compound of chitosan and ethambutol: ultrastructural biological evaluation in vitro against Mycobacterium tuberculosis.9167-917910.1007/s00253-021-11690-4Chitosan (CS) is a promising biopolymer and has been tested as a complement to the action and compensation of toxicity presented by anti-tuberculosis drugs. The present work studied the adjuvant effect of CS with the drug ethambutol (EMB) as a compound (CS-EMB), to explore its antimicrobial and cytotoxic activity, using transmission electron microscopy (TEM), to examine ultracellular changes that represent possible antimycobacterial action of CS on Mycobacterium tuberculosis (Mtb). Antimycobacterial activities were tested against reference strains Mtb ATCC® H37Rv and multidrug resistant (MDR). In vitro cytotoxicity tests were performed on Raw 264.7. For the studied compounds, morphological, ultrastructural, and physical-chemical analyses were performed. Drug-polymer interactions that occur through the H bridges were confirmed by physical-chemical analyses. The CS-EMB compound is stable at pHs of 6.5-7.5, allowing its release at physiological pH. The antibacterial activity (minimum inhibitory concentration) of the CS-EMB compound was 50% greater than that of the EMB in the H37Rv and MDR strains and the ultrastructural changes in the bacilli observed by TEM proved that the CS-EMB compound has a bactericidal action, allowing it to break down the Mtb cell wall. The cytotoxicity of CS-EMB was higher than that of isolated EMB, IC50 279, and 176 ?g/mL, respectively. It is concluded that CS-EMB forms a promising composite against strains Mtb H37Rv and multidrug resistant (MDR-TB).Key points? Our study will be the first to observe ultrastructurally the effects of the CS-EMB compound on Mtb cells.? CS-EMB antimicrobial activity in a multidrug-resistant clinical strain.? The CS-EMB compound has promising potential for the development of a new drug to fight tuberculosis.© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.OliveiraM E F A GMEFAGPrograma de Pós-Graduação Em Morfotecnologia, Universidade Federal de Pernambuco (UFPE), Recife, PE, 50670-420, Brazil. m.dudafago@gmail.com.SilvaY J AYJAPrograma de Pós-Graduação Em Ciência de Materiais, Universidade Federal de Pernambuco (UFPE), Recife, PE, 50740-560, Brazil.AzevedoL ALAPrograma de Pós-Graduação Em Ciência de Materiais, Universidade Federal de Pernambuco (UFPE), Recife, PE, 50740-560, Brazil.LinharesL ALAInstituto Aggeu Magalhães/Fundação Oswaldo Cruz (IAM/FIOCRUZ), 50740-465, Recife-PE, Brazil.MontenegroL M LLMLInstituto Aggeu Magalhães/Fundação Oswaldo Cruz (IAM/FIOCRUZ), 50740-465, Recife-PE, Brazil.AlvesSSJrDepartamento de Química Fundamental (dQF), Universidade Federal de Pernambuco (UFPE), Recife, PE, 50740-560, Brazil.AmorimR V SRVSDepartamento de Histologia E Embriologia (DHE-CB), Universidade Federal de Pernambuco (UFPE), Recife, PE, 50670-420, Brazil.engJournal Article20211129GermanyAppl Microbiol Biotechnol84066120175-75980Antitubercular Agents8G167061QZEthambutol9012-76-4ChitosanIMAntitubercular AgentstoxicityChitosanpharmacologyEthambutolpharmacologyHumansMicrobial Sensitivity TestsMycobacterium tuberculosisTuberculosis, Multidrug-ResistantChitosanCytotoxicityEthambutolMultidrug-resistantMycobacterium tuberculosisUltrastructural2021042320211108202110142021113060202112156020211129640ppublish3484146310.1007/s00253-021-11690-410.1007/s00253-021-11690-4References, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>112.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Clinical characteristics and chest computed tomography findings related to the infectivity of pulmonary tuberculosis.</a><a 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href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Higuchi R, Goto T, Hirotsu Y, Otake S, Oyama T, Amemiya K, Ohyama H, Mochizuki H, Omata M<br><font color=gray><i>Journal of personalized medicine, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>118.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Clinical Factors Associated with Cavitary Tuberculosis and Its Treatment Outcomes.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span 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