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Synonyms:
   Adonis vernalis (pheasant's eye) 
   Chrysocyathus vernalis 

Broader Terms:
   Adonis (pheasant's eye) 
   Ranunculales 
 
 
Latest Articles on Adonis vernalis L. from uBioRSS
The role of SORBITOL DEHYDROGENASE in Arabidopsis thaliana - Functional Plant Biology
Adonis vernalis - Plant Taxonomy Photo Pool


External Resources:

Common Names: spring pheasant's eye, oxeye, горицвет веценний, goricvet vecennij, oxeye daisy, våradonis, pheasant's eye, ruscuta primavaratica, spring adonis



61.  Targeting DNA damage response pathways to activate the STING innate immune signaling pathway in human cancer cells.LinkIT
Wayne J, Brooks T, Landras A, Massey AJ
The FEBS journalFEBS JTargeting DNA damage response pathways to activate the STING innate immune signaling pathway in human cancer cells.4507-454010.1111/febs.15747Activating stimulator of interferon genes to turn immunologically refractive cold tumor hot is an exciting therapeutic approach to increase the clinical responsiveness of some human cancers to immune checkpoint inhibitors. DNA damaging drugs and PARP inhibitors are two types of agents that have demonstrated this potential. Inhibitors of Chk1 or Wee1 induce DNA damage in cancer cells in predominantly the S-phase population. Increased cytoplasmic single-stranded and double-stranded DNA (dsDNA) from this DNA damage resulted in increased tank-binding kinase 1 (TBK1) phosphorylation in a range of cancer cell lines. However, despite robust increases in pTBK1, no downstream consequences of TBK1 phosphorylation were observed (namely no increase in pIRF3/7, interferon regulatory factor (IRF)-dependent gene expression or a type I IFN response). In combination with cytotoxic chemotherapy such as gemcitabine or camptothecin (CPT), Chk1 inhibition increased cytoplasmic dsDNA compared with the cytotoxic alone but attenuated the cytotoxic chemotherapy-induced increase in IRF1 protein and STAT1 phosphorylation through inhibition of nuclear RelB translocation. Despite increased cytoplasmic DNA and TBK1 activation, inhibition of Chk1, ataxia telangiectasia and Rad3-related protein, or Wee1 failed to activate a type I IFN response. We discuss the potential underlying mechanisms for this lack of IRF-dependent gene response and how this might influence the clinical strategies of combining Chk1 or Wee1 inhibitors with immune checkpoint inhibitors.© 2021 Federation of European Biochemical Societies.WayneJoanneJVernalis (R&D) Ltd, Cambridge, UK.BrooksTeresaTVernalis (R&D) Ltd, Cambridge, UK.LandrasAlexandraAVernalis (R&D) Ltd, Cambridge, UK.MasseyAndrew JAJ0000-0002-0276-2573Vernalis (R&D) Ltd, Cambridge, UK.engJournal Article20210218EnglandFEBS J1012296461742-464X0Cell Cycle Proteins0IRF3 protein, human0Immune Checkpoint Inhibitors0Interferon Regulatory Factor-30Membrane Proteins0STAT1 Transcription Factor0STING1 protein, humanEC 2.7.10.1Protein-Tyrosine KinasesEC 2.7.10.2WEE1 protein, humanEC 2.7.11.1ATR protein, humanEC 2.7.11.1Ataxia Telangiectasia Mutated ProteinsEC 2.7.11.1CHEK1 protein, humanEC 2.7.11.1Checkpoint Kinase 1EC 2.7.11.1Protein Serine-Threonine KinasesEC 2.7.11.1TBK1 protein, humanIMFEBS J. 2021 Aug;288(15):4503-450633811455Apoptosisdrug effectsAtaxia Telangiectasia Mutated ProteinsmetabolismCell Cycle ProteinsmetabolismCheckpoint Kinase 1antagonists & inhibitorsmetabolismDNA DamageHT29 CellsHumansImmune Checkpoint InhibitorstoxicityImmunity, InnateInterferon Regulatory Factor-3metabolismMembrane ProteinsmetabolismNeoplasmsgeneticsimmunologymetabolismPhosphorylationProtein Serine-Threonine KinasesmetabolismProtein-Tyrosine KinasesmetabolismSTAT1 Transcription FactormetabolismSignal TransductionATRChk1STINGWee1innate immune response202012212020091620210201202123602021827602021221716ppublish3352943810.1111/febs.15747References, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>62.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Characteristics of the vaginal microbiomes in prepubertal girls with and without vulvovaginitis.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Xiaoming W, Jing L, Yuchen P, Huili L, Miao Z, Jing S<br><font color=gray><i>European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>63.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Association Between Serum Thyroid-Stimulating Hormone Levels and Salivary Microbiome Shifts.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Dong T, Zhao F, Yuan K, Zhu X, Wang N, Xia F, Lu Y, Huang Z<br><font color=gray><i>Frontiers in cellular and infection microbiology, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>64.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Complete chloroplast genome of <i>adonis amurensis</i> (ranunculaceae), an important cardiac folk medicinal plant in east asia.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Zhang LQ, Zhang XY, Hu YW, Sun RS, Yu JL<br><font color=gray><i>Mitochondrial DNA. Part B, Resources, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>65.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Evaluating Accuracy of DNA Pool Construction Based on White Blood Cell Counts.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Abrams AN, McDaneld TG, Keele JW, Chitko-McKown CG, Kuehn LA, Gonda MG<br><font color=gray><i>Frontiers in genetics, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>66.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Fecal transplantation alleviates acute liver injury in mice through regulating Treg/Th17 cytokines balance.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Liu Y, Fan L, Cheng Z, Yu L, Cong S, Hu Y, Zhu L, Zhang B, Cheng Y, Zhao P, Zhao X, Cheng M<br><font color=gray><i>Scientific reports, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>67.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Geography as non-genetic modulation factor of chicken cecal microbiota.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Pin Viso N, Redondo E, Díaz Carrasco JM, Redondo L, Sabio Y Garcia J, Fernández Miyakawa M, Farber MD<br><font color=gray><i>PloS one, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>68.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Ching KH, Berg K, Reynolds K, Pedersen D, Macias A, Abdiche YN, Harriman WD, Leighton PA<br><font color=gray><i>mAbs, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>69.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Shifts in the Bacterial Community of Supragingival Plaque Associated With Metabolic-Associated Fatty Liver Disease.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Zhao F, Dong T, Yuan KY, Wang NJ, Xia FZ, Liu D, Wang ZM, Ma R, Lu YL, Huang ZW<br><font color=gray><i>Frontiers in cellular and infection microbiology, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>70.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Protein-fragment complex structures derived by NMR molecular replacement.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Torres F, Ghosh D, Strotz D, Chi CN, Davis B, Orts J<br><font color=gray><i>RSC medicinal chemistry, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br><br><br><table cellspacing=0 cellpadding=0 align=center><tr valign=bottom><td align=center><a 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