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Synonyms:
   Rubia tinctoria (madder) 
   Rubia tinctorum (madder) 

Broader Terms:
   Rubia 
   Rubiales 
 
 
Latest Articles on Rubia tinctorum L from uBioRSS
Identification of dyestuffs in historical textiles: Strong and weak points ... - ScienceDirect Search: species
Herbal extract works as environmentally friendly battery cathode - Science Blog


Rubia tinctorum
BioLib Online Library

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Common Names: Robbia, madder, krapp, bacho



1.  Measuring quantitative proteomic distance between Spanish beef breeds.LinkIT
Rodríguez-Vázquez R, Mato A, López-Pedrouso M, Franco D, Sentandreu MA, Zapata C
Food chemistry, 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

2.  Purpurin exerted antidepressant-like effects on behavior and stress axis reactivity: evidence of serotonergic engagement.LinkIT
Ma L, Hu P, Zhang J, Cui W, Zhao X
Psychopharmacology, 2020
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0

3.  3-O-acetylrubianol C (3AR-C) induces RIPK1-dependent programmed cell death by selective inhibition of IKK?.LinkIT
Kang K, Quan KT, Byun HS, Lee SR, Piao X, Ju E, Park KA, Sohn KC, Shen HM, Na M, Hur GM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology FASEB J. 3-O-acetylrubianol C (3AR-C) induces RIPK1-dependent programmed cell death by selective inhibition of IKK?. 10.1096/fj.201902547R In tumor necrosis factor (TNF) signaling, phosphorylation and activation of receptor interacting protein kinase 1 (RIPK1) by upstream kinases is an essential checkpoint in the suppression of TNF-induced cell death. Thus, discovery of pharmacological agents targeting RIPK1 may provide new strategies for improving the therapeutic efficacy of TNF. In this study, we found that 3-O-acetylrubianol C (3AR-C), an arborinane triterpenoid isolated from Rubia philippinesis, promoted TNF-induced apoptotic and necroptotic cell death. To identify the molecular mechanism, we found that in mouse embryonic fibroblasts, 3AR-C drastically upregulated RIPK1 kinase activity by selectively inhibiting IKK?. Notably, 3AR-C did not interfere with IKK? or affect the formation of the TNF receptor1 (TNFR1) complex-I. Moreover, in human cancer cells, 3AR-C was only sufficient to sensitize TNF-induced cell death when c-FLIPL expression was downregulated to facilitate the formation of TNFR1 complex-II and necrosome. Taken together, our study identified a novel arborinane triterpenoid 3AR-C as a potent activator of TNF-induced cell death via inhibition of IKK? phosphorylation and promotion of the cytotoxic potential of RIPK1, thus providing a rationale for further development of 3AR-C as a selective IKK? inhibitor to overcome TNF resistance in cancer therpay. © 2020 Federation of American Societies for Experimental Biology. Kang Kidong K Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea. Quan Khong Trong KT College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea. Byun Hee Sun HS Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea. Lee So-Ra SR Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea. Piao Xuezhe X Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea. Ju Eunjin E Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea. Park Kyeong Ah KA Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea. Sohn Kyung-Cheol KC Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea. Shen Han-Ming HM Faculty of Health Sciences, University of Macau, Macau, China. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Na MinKyun M College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea. Hur Gang Min GM Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea. eng 2017R1A2A1A05001225 National Research Foundation of Korea (NRF) 2017R1A5A2015385 National Research Foundation of Korea (NRF) 2017R1A2A2A05001340 National Research Foundation of Korea (NRF) Journal Article 2020 02 06 United States FASEB J 8804484 0892-6638 IM 3AR-C IKK? RIPK1 TNF apoptosis necroptosis phosphorylation 2019 10 08 2020 01 04 2020 01 12 2020 2 7 6 0 2020 2 7 6 0 2020 2 7 6 0 aheadofprint 32027418 10.1096/fj.201902547R REFERENCES, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>4.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>An integrated multiple reaction monitoring strategy based on predicted precursor ions and characteristic product ions for global profiling Rubiaceae-type cyclopeptides in three Rubiaspecies.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Bi Q, Liu Q, Han S, Zhang L, Xing L, Zhang X, Wang Z, Miao Y, Tan N<br><font color=gray><i>Journal of chromatography. A, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>5.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>A short note on the reliability of perceptual timing tasks as commonly used in research on developmental disorders.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Marx I, Rubia K, Reis O, Noreika V<br><font color=gray><i>European child & adolescent psychiatry, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>6.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Selection and Validation of Appropriate Reference Genes for Quantitative RT-PCR Analysis in <i>Rubia yunnanensis</i> Diels Based on Transcriptome Data.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Yi S, Lin Q, Zhang X, Wang J, Miao Y, Tan N<br><font color=gray><i>BioMed research international, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>7.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>A multivariate analysis with direct additive and inbreeding depression load effects.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Varona L, Altarriba J, Moreno C, Martínez-Castillero M, Casellas J<br><font color=gray><i>Genetics, selection, evolution : GSE, 2019</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>8.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Validation of the Mexican Spanish Version of the Scale of Positive and Negative Experience in a Sample of Medical and Psychology Students.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Daniel-González L, de la Rubia JM, Valle de la O A, García-Cadena CH, Martínez-Martí ML<br><font color=gray><i>Psychological reports, 2019</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>9.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Tuberculosis in prison and aspects associated with the diagnosis site.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Ferreira MR, Bonfim RO, Siqueira TC, Andrade RLP, Monroe AA, Villa TC, Orfão NH<br><font color=gray><i>Journal of infection in developing countries, 2019</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>10.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Evaluation of different Pakistani medicinal plants for inhibitory potential against Echis carinatus induced Phospholipase A2 toxicity.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Fatima S, Javed T, Khalid S, Shaheen N, Aslam N, Latif M, Siddique FA, Bibi S, Mohsin S, Yameen MA, Ali Abid SM, Khan SA, Najam A, Afzal K, Hasan SMF, McCleary RJ, Bin Asad MHH<br><font color=gray><i>Pakistan journal of pharmaceutical sciences, 2019</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br><br><br><table cellspacing=0 cellpadding=0 align=center><tr valign=bottom><td align=center><img src=p.png border=0></td><td align=center><img src=o_red.png border=0></td><td align=center><a href=http://ubio.org/portal/index.php?search=Rubia+tinctorum+L&category=l&client=pubmed&startPage=2><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Rubia+tinctorum+L&category=l&client=pubmed&startPage=3><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Rubia+tinctorum+L&category=l&client=pubmed&startPage=4><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Rubia+tinctorum+L&category=l&client=pubmed&startPage=5><img src=o_yellow.png border=0></a></td><td align=center><a 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