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Synonyms:
   Ixora 

Broader Terms:
   Ixora 
   Ixoreae 
   Rubiaceae (madders) 

More Specific:
   Charpentiera australis 
   Charpentiera densiflora (Dense-flowered charpenttiera) 
   Charpentiera elliptica (ellipticleaf papala) 
   Charpentiera obovata (broadleaf papala) 
   Charpentiera ovata (Koolau Range papala) 
   Charpentiera tomentosa (Waianae Range papala) 
   Ixora 
   Ixora abyssinica 
   Ixora accedens 
   Ixora aciculiflora 
   Ixora acuminata (bola de nieve) 
   Ixora acuminatissima 
   Ixora acuticauda 
   Ixora aegialodes 
   Ixora affinis 
   Ixora agasthyamalayana 
   Ixora aggregata 
   Ixora agostiniana 
   Ixora akkeringae 
   Ixora alba 
   Ixora albersii 
   Ixora aluminicola 
   Ixora amapaensis 
   Ixora amara 
   Ixora amboinica 
   Ixora americana 
   Ixora amherstiensis 
   Ixora amoena 
   Ixora amplexicaulis 
   Ixora amplexifolia 
   Ixora amplifolia 
   Ixora andamanensis 
   Ixora aneimenodesma 
   Ixora aneityensis 
   Ixora angulata 
   Ixora angustifolia 
   Ixora angustilimba 
   Ixora aphylla 
   Ixora arborea 
   Ixora arborescens 
   Ixora archboldii 
   Ixora arenosa 
   Ixora arestantha 
   Ixora argentea 
   Ixora arguta 
   Ixora arnottiana 
   Ixora asme 
   Ixora assimilis 
   Ixora asteriscus 
   Ixora athroantha 
   Ixora auricularis 
   Ixora auriculata 
   Ixora aurorea 
   Ixora backeri 
   Ixora bahiensis 
   Ixora baileyana 
   Ixora balakrishnii 
   Ixora balansae 
   Ixora baldwinii 
   Ixora balinensis 
   Ixora bancana 
   Ixora bandhuca 
   Ixora banjoana 
   Ixora barbata 
   Ixora barberae 
   Ixora bartilingii 
   Ixora bartlingii 
   Ixora batesii 
   Ixora batuensis 
   Ixora bauchiensis 
   Ixora baviensis 
   Ixora beckleri 
   Ixora beddomei 
   Ixora bemangidiensis 
   Ixora benthamiana 
... 
 
Latest Articles on Ixora st.-johnii Fosberg from uBioRSS
Ixora nigricans R.Br. ex Wight & Arn. - Plant Taxonomy Photo Pool
Revision of Ixora (Rubiaceae) in the Marquesas Islands (French Polynesia) - Latest Issue of Botanical Journal of the Linnean S...


External Resources:

Common Names: ixora



1.  Population pharmacokinetic and exposure-efficacy analysis of ixekizumab in paediatric patients with moderate-to-severe plaque psoriasis (IXORA-PEDS).LinkIT
Jackson K, Chua L, Velez de Mendizabal N, Pitou C, Rodriguez Capriles C, Paller AS, Lansang P, Seyger MMB, Papp K,
British journal of clinical pharmacologyBr J Clin PharmacolPopulation pharmacokinetic and exposure-efficacy analysis of ixekizumab in paediatric patients with moderate-to-severe plaque psoriasis (IXORA-PEDS).10.1111/bcp.15034Ixekizumab is a high-affinity monoclonal antibody that selectively targets interleukin-17A used in the treatment of adult and paediatric patients with moderate-to-severe psoriasis. This analysis evaluated the pharmacokinetics (PK) of ixekizumab and the exposure-efficacy relationship in paediatric patients aged 6 to <18?years with psoriasis.Population PK and exposure-efficacy models were developed. The models used data from paediatric patients with psoriasis participating in the Phase 3 IXORA-PEDS trial in which patients were dosed according to weight categories. The exposure-efficacy model is a Psoriasis Area and Severity Index (PASI) time course model using data up to Week 12, a co-primary efficacy endpoint.A 2-compartment population PK model describes the PK of ixekizumab in paediatric patients with the effect of body weight incorporated on clearance and volume terms using an allometric relationship. The weight category-based dosing ensured that ixekizumab mean trough serum concentrations in paediatric patients with psoriasis (3.20-3.33??g/mL) were within the range of concentrations observed in adult patients with psoriasis (mean [standard deviation]: 3.48 [2.16] ?g/mL) administered an efficacious dosing regimen. The observed PASI response rates at Week 12 in paediatric patients (91.9/81.8/52.5% for PASI75/90/100) are well predicted by the final exposure-efficacy model and response rates are similar or higher than those achieved in adults (86.2/66.6/35.0% for PASI75/90/100).This analysis is the first to describe the PK and exposure-efficacy relationship of ixekizumab in paediatric patients with psoriasis. The analyses support the selection of the weight category-based ixekizumab dosing regimens approved for use in paediatric patients with psoriasis.© 2021 Eli Lilly and company. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.JacksonKimberleyKhttps://orcid.org/0000-0002-1917-5164Eli Lilly and Company, Bracknell, UK.ChuaLaiyiLLilly Centre for Clinical Pharmacology, Singapore, Singapore.Velez de MendizabalNievesNMetrum Research Group, LLC, Tariffville, CT, USA.PitouCelineCEli Lilly and Company, Bracknell, UK.Rodriguez CaprilesClaudiaCEli Lilly and Company, Indianapolis, IN, USA.PallerAmy SASDepartment of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.LansangPerlaPSunnybrook Health Sciences Centre, Toronto, ON, Canada.SeygerMarieke M BMMBDepartment of Dermatology, Radboud University Medical Centre, Nijmegen, The Netherlands.PappKimKK Papp Clinical Research and Probity Medical Research, Waterloo, ON, Canada.IXORA-PEDS study groupengEli Lilly and CompanyJournal Article20210810EnglandBr J Clin Pharmacol75033230306-5251IMixekizumabpaediatricpharmacokineticspharmacokinetics-pharmacodynamicspopulation pharmacokineticspsoriasis2021072320210330202107312021812602021812602021811659aheadofprint3437823010.1111/bcp.15034REFERENCES, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>2.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Ixekizumab for the treatment of pediatric patients with moderate to severe plaque psoriasis.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Cather JC, Young CT, Young MS, Cather JC<br><font color=gray><i>Expert opinion on biological therapy, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>3.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Efficacy of ixekizumab on nail psoriasis in paediatric patients with moderate-to-severe psoriasis: a post hoc analysis from IXORA-PEDS.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Seyger MMB, Reich A, El Baou C, Schuster C, Riedl E, Paller AS<br><font color=gray><i>Journal of the European Academy of Dermatology and Venereology : JEADVJ Eur Acad Dermatol VenereolEfficacy of ixekizumab on nail psoriasis in paediatric patients with moderate-to-severe psoriasis: a post hoc analysis from IXORA-PEDS.10.1111/jdv.17564SeygerM M BMMBhttps://orcid.org/0000-0003-0516-8294Department of Dermatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.ReichAAhttps://orcid.org/0000-0002-5573-1754Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland.El BaouCCEli Lilly and Company, Indianapolis, IN, USA.SchusterCCEli Lilly and Company, Indianapolis, IN, USA.Department of Dermatology, Medical University of Vienna, Vienna, Austria.RiedlEEEli Lilly and Company, Indianapolis, IN, USA.Department of Dermatology, Medical University of Vienna, Vienna, Austria.PallerA SAShttps://orcid.org/0000-0001-6187-6549Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.engEli Lilly and CompanyLetter20210728EnglandJ Eur Acad Dermatol Venereol92160370926-9959IM20210623202105112021072720217296020217296020217281730aheadofprint3432025910.1111/jdv.17564References, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>4.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Bioguided Fractionation of Local Plants against Matrix Metalloproteinase9 and Its Cytotoxicity against Breast Cancer Cell Models: In Silico and In Vitro Study (Part II).</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Hariono M, Rollando R, Yoga I, Harjono A, Suryodanindro A, Yanuar M, Gonzaga T, Parabang Z, Hariyono P, Febriansah R, Hermawansyah A, Setyani W, Wahab H<br><font color=gray><i>Molecules (Basel, Switzerland), 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>5.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Phytoremediation for urban landscaping and air pollution control-a case study in Trivandrum city, Kerala, India.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Watson AS, Bai R S<br><font color=gray><i>Environmental science and pollution research international, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>6.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Clinical Utility of Guselkumab in the Treatment of Moderate-to-Severe Plaque Psoriasis.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Light JG, Su JJ, Feldman SR<br><font color=gray><i>Clinical, cosmetic and investigational dermatology, 2021</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>7.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>An Analysis of Patient-reported Outcomes in IXORA-S: Comparing Ixekizumab and Ustekinumab over 52 Weeks in Moderate-to-severe Psoriasis.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Puig L, Lomaga M, Hollister K, Dutronc Y, Berggren L, van de Kerkhof PCM<br><font color=gray><i>Acta dermato-venereologica, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>8.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>In vitro antimicrobial activity of plant fractions against major respiratory pathogens.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Abbas T, Sara B, Shoaib A<br><font color=gray><i>Pakistan journal of pharmaceutical sciences, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>9.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>A green extraction design for enhancing flavonoid compounds from <i>Ixora javanica</i> flowers using a deep eutectic solvent.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Oktaviyanti ND, Kartini K, Hadiyat MA, Rachmawati E, Wijaya AC, Hayun H, Mun'im A<br><font color=gray><i>Royal Society open science, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>10.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Early Treatment Targets for Predicting Long-term Dermatology Life Quality Index Response in Patients with Moderate-to-Severe Plaque Psoriasis: A <i>Post-hoc</i> Analysis from a Long-term Clinical Study.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Puig L, Zhu B, Burge R, Shrom D, Dong Y, Shen W, Mallbris L, Reich K<br><font color=gray><i>The Journal of clinical and aesthetic dermatology, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br><br><br><table cellspacing=0 cellpadding=0 align=center><tr valign=bottom><td align=center><img src=p.png border=0></td><td align=center><img src=o_red.png border=0></td><td align=center><a href=http://ubio.org/portal/index.php?search=Ixora+st.-johnii+Fosberg&category=l&client=pubmed&startPage=2><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Ixora+st.-johnii+Fosberg&category=l&client=pubmed&startPage=3><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Ixora+st.-johnii+Fosberg&category=l&client=pubmed&startPage=4><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Ixora+st.-johnii+Fosberg&category=l&client=pubmed&startPage=5><img src=o_yellow.png border=0></a></td><td align=center><a 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