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Synonyms:
   Bauhinia forficata (cow's-foot) 

Broader Terms:
   Bauhinia 
   Rosales 

More Specific:
   Bauhinia forficata forficata 
   Bauhinia forficata longiflora 
   Bauhinia forficata pruinosa (Pata de Chivo) 
 
 
Latest Articles on Bauhinia forficata Link from uBioRSS
Green Chromatographic Fingerprinting: An environmentally friendly approach ... - Journal of Separation Science
Plants used as antidiabetics in popular medicine in Rio Grande do Sul, sout... - ScienceDirect Search: species


External Resources:

Common Names: cow's-foot, Brazilian Orchid-Tree



1.  Production of the bioactive plant-derived triterpenoid morolic acid in engineered Saccharomyces cerevisiae.LinkIT
Srisawat P, Yasumoto S, Fukushima EO, Robertlee J, Seki H, Muranaka T
Biotechnology and bioengineering Biotechnol. Bioeng. Production of the bioactive plant-derived triterpenoid morolic acid in engineered Saccharomyces cerevisiae. 2198-2208 10.1002/bit.27357 Morolic acid is a plant-derived triterpenoid that possesses pharmacological properties such as cytotoxicity, as well as anti-HIV, anti-HSV, anti-inflammatory, and antidiabetic effects. The significant therapeutic properties of morolic acid are desirable in the context of pharmacological and drug development research, but the low accessibility of morolic acid from natural resources limits its applications. In the present study, we developed a microbial system for the production of morolic acid. Using a combinatorial biosynthesis approach, a novel production pathway was constructed in Saccharomycescerevisiae by coexpressing BfOSC2 (germanicol synthase) from Bauhinia forficata and CYP716A49 (triterpene C-28 oxidase) from Beta vulgaris. Moreover, we reconstructed the cellular galactose regulatory network by introducing a chimeric transcriptional activator (fusion of Gal4dbd.ER.VP16) to overdrive the genes under the control of the galactose promoter. We also overexpressed truncated HMG1, encoding feedback-inhibition-resistant form of 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 and sterol-regulating transcription factor upc2-1, to increase the isoprenoid precursors in the mevalonate pathway. Using this yeast system, we achieved morolic acid production up to 20.7?±?1.8?mg/L in batch culture. To our knowledge, this is the highest morolic acid titer reported from a heterologous host, indicating a promising approach for obtaining rare natural triterpenoids. © 2020 Wiley Periodicals LLC. Srisawat Pisanee P Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan. RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan. Yasumoto Shuhei S Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan. Fukushima Ery O EO Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan. Department of Biotechnology, Faculty of Life Sciences, Universidad Regional Amazónica IKIAM, Tena, Ecuador. Robertlee Jekson J Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan. Department of Frontier Research, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan. Seki Hikaru H Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan. Muranaka Toshiya T http://orcid.org/0000-0003-1058-2473 Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan. eng The Frontier Research Base for Global Young Researchers JP19H02921 Grant-in-Aid for Scientific Research JP19H04657 Grant-in-Aid for Scientific Research Sunbor Grant from Suntory Foundation of Life Sciences Journal Article 2020 05 08 United States Biotechnol Bioeng 7502021 0006-3592 IM GEV chimeric transcription factor Saccharomyces cerevisiae metabolic engineering morolic acid triterpenoid 2019 10 25 2020 04 16 2020 04 17 2020 4 21 6 0 2020 4 21 6 0 2020 4 21 6 0 ppublish 32311084 10.1002/bit.27357 REFERENCES, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>2.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Diuretic and Renal Protective Effect of Kaempferol 3-<i>O</i>-Alpha-l-rhamnoside (Afzelin) in Normotensive and Hypertensive Rats.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Cechinel-Zanchett CC, Bolda Mariano LN, Boeing T, da Costa JC, Da Silva LM, Bastos JK, Cechinel-Filho V, de Souza P<br><font color=gray><i>Journal of natural products, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>3.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Antidiabetic potential of <b>Bauhinia forficata Link</b> leaves: a non-cytotoxic source of lipase and glycoside hydrolases inhibitors and molecules with antioxidant and antiglycation properties.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Franco RR, Mota Alves VH, Ribeiro Zabisky LF, Justino AB, Martins MM, Saraiva AL, Goulart LR, Espindola FS<br><font color=gray><i>Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>4.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Therapeutic Potential of <i>Bauhinia forficata</i> Link in Dental Biofilm Treatment.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Ferreira-Filho JCC, Marre ATO, de Sá Almeida JS, Lobo LA, Farah A, Romanos MTV, Maia LC, Valença AMG, Fonseca-Gonçalves A<br><font color=gray><i>Journal of medicinal food, 2020</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>5.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Proteomic characterization of medicinal plants used in the treatment of diabetes.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Pedrete TA, Hauser-Davis RA, Moreira JC<br><font color=gray><i>International journal of biological macromolecules, 2019</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>6.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title><b>Bauhinia forficata link</b>, a Brazilian medicinal plant traditionally used to treat cardiovascular disorders, exerts endothelium-dependent and independent vasorelaxation in thoracic aorta of normotensive and hypertensive rats.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Cechinel-Zanchett CC, da Silva RCMVAF, Tenfen A, Siebert DA, Micke G, Vitali L, Cechinel-Filho V, Faloni de Andrade S, de Souza P<br><font color=gray><i>Journal of ethnopharmacology, 2019</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>7.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Identification of oxidosqualene cyclases from the medicinal legume tree Bauhinia forficata: a step toward discovering preponderant ?-amyrin-producing activity.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Srisawat P, Fukushima EO, Yasumoto S, Robertlee J, Suzuki H, Seki H, Muranaka T<br><font color=gray><i>The New phytologist New Phytol. Identification of oxidosqualene cyclases from the medicinal legume tree Bauhinia forficata: a step toward discovering preponderant ?-amyrin-producing activity. 352-366 10.1111/nph.16013 Triterpenoids are widely distributed among plants of the legume family. However, most studies have focused on triterpenoids and their biosynthetic enzymes in model legumes. We evaluated the triterpenoid aglycones profile of the medicinal legume tree Bauhinia forficata by gas chromatography-mass spectrometry. Through transcriptome analyses, homology-based cloning, and heterologous expression, we discovered four oxidosqualene cyclases (OSCs) which are responsible for the diversity of triterpenols in B. forficata. We also investigated the effects of the unique motif TLCYCR on ?-amyrin synthase activity. B. forficata highly accumulated ?-amyrin. We discovered an OSC with a preponderant ?-amyrin-producing activity, which accounted for at least 95% of the total triterpenols. We also discovered three other functional OSCs (BfOSC1, BfOSC2, and BfOSC4) that produce ?-amyrin, germanicol, and cycloartenol. Furthermore, by replacing the unique motif TLCYCR from BfOSC3 with the MWCYCR motif, we altered the function of BfOSC3 such that it no longer produced ?-amyrin. Our results provide new insights into OSC cyclization, which is responsible for the diversity of triterpenoid metabolites in B. forficata, a non-model legume plant. © 2019 The Authors. New Phytologist © 2019 New Phytologist Trust. Srisawat Pisanee P Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, 565-0871, Japan. Fukushima Ery Odette EO 0000-0003-4099-4292 Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, 565-0871, Japan. Universidad Regional Amazónica IKIAM, Tena, 150150, Ecuador. Yasumoto Shuhei S Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, 565-0871, Japan. Robertlee Jekson J Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, 565-0871, Japan. Department of Frontier Research, Kazusa DNA Research Institute, Kisarazu, 292-0818, Japan. Suzuki Hideyuki H Department of Research & Development, Kazusa DNA Research Institute, Kisarazu, 292-0818, Japan. Seki Hikaru H Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, 565-0871, Japan. Muranaka Toshiya T 0000-0003-1058-2473 Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, 565-0871, Japan. eng GENBANK BAA89815 ACA13386 BAB83088 BAA97558 BAE53429 BAF80443 AAO33578 ACH88049 BAE53430 BAA86930 BAA86932 BAD08587 BAB83087 BAF80444 AHF22084 NP178018 ALR73780 AFH53506 BAA97559 ACM89977 AFP95334 BAF63702 AFJ19235 AIS39739 LC464978 LC464979 LC464980 LC464981 Journal Article Research Support, Non-U.S. Gov't 2019 08 04 England New Phytol 9882884 0028-646X 0 Pentacyclic Triterpenes 2ZD004190S Threonine 30ZAG40J8N alpha-amyrin EC 5.4.- Intramolecular Transferases EC 5.4.99.7 lanosterol synthase GMW67QNF9C Leucine IM Amino Acid Motifs Amino Acid Sequence Bauhinia enzymology genetics Biosynthetic Pathways Gene Expression Profiling Gene Expression Regulation, Plant Intramolecular Transferases chemistry genetics isolation & purification metabolism Leucine metabolism Pentacyclic Triterpenes chemistry metabolism Phylogeny Plants, Genetically Modified Saccharomyces cerevisiae metabolism Structure-Activity Relationship Threonine metabolism Tobacco genetics metabolism Trees enzymology Bauhinia forficata non-model legume oxidosqualene cyclase triterpenoid ?-amyrin 2019 05 02 2019 06 15 2019 6 24 6 0 2020 5 6 6 0 2019 6 24 6 0 ppublish 31230357 10.1111/nph.16013 References, 2019</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>8.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Modulation of the resistance to norfloxacin in Staphylococcus aureus by <b>Bauhinia forficata link</b>.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>de Sousa JN, de Oliveira ABM, Ferreira AK, Silva E, de Sousa LMS, França Rocha MC, de JP, Júnior S, William Kaatz G, da Silva Almeida JRG, de Souza JSN, Medeiros Barreto H<br><font color=gray><i>Natural product research, 2019</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>9.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Effects of <i>Bauhinia forficata</i> on glycaemia, lipid profile, hepatic glycogen content and oxidative stress in rats exposed to Bisphenol A.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Pinafo MS, Benedetti PR, Gaiotte LB, Costa FG, Schoffen JPF, Fernandes GSA, Chuffa LGA, Seiva FRF<br><font color=gray><i>Toxicology reports, 2019</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br>10.  <a href=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0 class=title>Effects of <b>Bauhinia forficata Link</b> Tea on Lipid Profile in Diabetic Patients.</a><a href=http://ubio.org/tools/linkit.php?map%5B%5D=all&link_type=2&url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0><img src=linkit.png border=0 title='LinkIT' alt='LinkIT'></a> <br><span class=j>Córdova Mariángel P, Avello Lorca M, Morales Leon F, Fernández Rocca P, Villa Zapata L, Pastene Navarrete E<br><font color=gray><i>Journal of medicinal food, 2019</i></font><br><font color=#008000>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=0<br></font></span><br><br><br><table cellspacing=0 cellpadding=0 align=center><tr valign=bottom><td align=center><img src=p.png border=0></td><td align=center><img src=o_red.png border=0></td><td align=center><a href=http://ubio.org/portal/index.php?search=Bauhinia+forficata+Link&category=l&client=pubmed&startPage=2><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Bauhinia+forficata+Link&category=l&client=pubmed&startPage=3><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Bauhinia+forficata+Link&category=l&client=pubmed&startPage=4><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Bauhinia+forficata+Link&category=l&client=pubmed&startPage=5><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Bauhinia+forficata+Link&category=l&client=pubmed&startPage=6><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Bauhinia+forficata+Link&category=l&client=pubmed&startPage=7><img src=o_yellow.png border=0></a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Bauhinia+forficata+Link&category=l&client=pubmed&startPage=2><img src=rtal.png border=0></a></td></tr><td align=center></td><td align=center>1</td><td align=center><a href=http://ubio.org/portal/index.php?search=Bauhinia+forficata+Link&category=l&client=pubmed&startPage=2>2</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Bauhinia+forficata+Link&category=l&client=pubmed&startPage=3>3</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Bauhinia+forficata+Link&category=l&client=pubmed&startPage=4>4</a></td><td align=center><a href=http://ubio.org/portal/index.php?search=Bauhinia+forficata+Link&category=l&client=pubmed&startPage=5>5</a></td><td align=center><a 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